个人简历

2007-至今：中国农业大学生物学院(全职)
2002-2007：美国国立犹太人医学研究中心免疫系
1997-2002：清华大学生命科学院化学生物学专业 理学博士
1994-1997：清华大学 经济管理学院企业管理专业理学学士
1992-1997：清华大学 化学系物理化学及仪器分析专业理学学士

研究领域

1. 蛋白质晶体学
2. 结构生物学
3. 植物生理学
4. 病毒学
5. 肿瘤学""

近期论文

1. Zizi Tian, Xiaorong Li, Min Li, WeiWu, Manfeng Zhang, Chenjun Tang, Zhihui Li, Yunlong Liu, Zhenhang Chen, Meiting Yang, Lulu Ma, Cody Caba, Yufeng Tong, Hon-Ming Lam, Shaodong Dai, Zhongzhou Chen*. Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms. Cell Discovery, 2020, 6, 17.
2. Chenjun Tang, Zengqin Deng, Xiaorong Li, Meiting Yang, Zizi Tian, Zhenhang Chen, Guoguo Wang, WeiWu, Wen-hai Feng, Gongyi Zhang, Zhongzhou Chen*. Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure. Viruses. 2020, 12(2), 215.
3. Li-Fei Tian, Yan-Ping Liu, Lianqi Chen, Qun Tang, Wei Wu, Wei Sun, Zhongzhou Chen*, Xiao-Xue Yan*. Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1. Cell Research, 2020, 30(3):272-275.
4. Wenli Tian, Min Li, Huiyuan Guo, Wenjun Peng, Xiaofeng Xue, Yifan Hu, Yang Liu, Yazhou Zhao, Xiaoming Fang, Kai Wang, Xiuting Li, Yufeng Tong, Michael A. Conlon, Wei Wu, Fazheng Ren, Zhongzhou Chen*. Architecture of the Native Major Royal Jelly Protein 1 Oligomer. Nature Comm. 2018, 9:3373.
5. Xiaoqiang Han, Lun Jiang, Chuanliang Che, Chuan Wan, Huizhe Lu, Yumei Xiao, Yanjun Xu, Zhongzhou Chen*, Zhaohai Qin*. Design and functional characterization of a novel abscisic acid analog. Scientific Reports, 2017, 7: 43863.
6. Yina Gao, Qi Zhang, Yue Lang, Yang Liu, Xiaofei Dong, Zhenhang Chen, Wenli Tian, Jun Tang, Wei Wu, Yufeng Tong, Zhongzhou Chen*. Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation. Journal of Molecular Cell Biology, 2017, 9 (3): 220-230.
7. Manfeng Zhang, Xiaorong Li, Zengqin Deng, Zhenhang Chen, Yang Liu, Yina Gao, Wei Wu, Zhongzhou Chen*. Structural Biology of the Arterivirus nsp11 Endoribonucleases. J Virol, 2017, 91: e01309-16.
8. Ming-Yan Cheung, Xiaorong Li, Rui Miao, Yu-Hang Fong, Kwan-Pok Li_x001f_, Yuk-Lin Yung, Mei-Hui Yu, Kam-Bo Wong*, Zhongzhou Chen*, Hon-Ming Lam*. ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses. PNAS, 2016, 113(10):2648-53.
9. Lun Jiang, Yibo Chen, Jiangge Zheng, Zhenhang Chen, Yujie Liu, Ye Tao, Wei Wu, Zhongzhou Chen*, Baichen Wang*. Structural basis of reversible phosphorylation by maize pyruvate orthophosphate dikinase regulatory protein. Plant Physiology. 2016, 170(2):732-41.
10. Yue Xing, Yufeng Hu, Lun Jiang, Zideng Gao, Zhenhang Chen, Zhongzhou Chen*, Xueqin Ren*. Zwitterion-Immobilized Imprinted Polymers for Promoting the Crystallization of Proteins. Cryst. Growth Des. 2015, 15 (10), 4932–4937.
11. Jiangge Zheng, Yue Lang, Qi Zhang, Di Cui, Haili Sun, Lun Jiang, Zhenhang Chen, Rui Zhang, Yina Gao, Wenli Tian, Wei Wu, Jun Tang*, Zhongzhou Chen*. Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. Genes & Development. 2015,29(14):1524-34.
12. Yufeng Hu, Zhenhang Chen, Yanjun Fu, Qingzhong He, Lun Jiang, Jiangge Zheng, Yina Gao, Pinchao Mei, Zhongzhou Chen*, Xueqin Ren*. The amino-terminal structure of human Fragile X Mental Retardation Protein obtained using precipitant-immobilized imprinted polymers. Nature Comm. 2015, 6:6634.
13. Zengqin Deng, Qing Wang, Zhao Liu, Manfeng Zhang, Ana Carolina Dantas Machado, Tsu-Pei Chiu, Chong Feng, Qi Zhang, Lin Yu, Lei Qi, Jiangge Zheng, Xu Wang, XinMei Huo, Xiaoxuan Qi, Xiaorong Li, Wei Wu, Remo Rohs*, Ying Li*, Zhongzhou Chen*. Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Nature Comm. 2015,6:7642.
14. gliang Zhang*, Lun Jiang, Qi Xin, Yang Liu, Jianxin Tan, Zhongzhou Chen*. Structural Basis and Functions of Abscisic Acid Receptors PYLs. Frontiers in Plant Science. 2015, 6:88.
15. Guoqiang Wang, Qingzhong He, Chong Feng, Yang Liu, Zengqin Deng, Xiaoxuan Qi, Wei Wu, Pinchao Mei, Zhongzhou Chen*. The atomic-resolution structure of human alkb homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism. J Biol Chem. 2014;289(40):27924-36.
16. Chong Feng, Yang Liu, Guoqiang Wang, Zengqin Deng, Qi Zhang, Wei Wu, Yufeng Tong, Changmei Cheng*, Zhongzhou Chen*. Crystal structures of the human rna demethylase Alkbh5 reveal basis for substrate recognition. J Biol Chem, 2014;289(17):11571-83
17. Zengqin Deng, Kathleen C. Lehmann, Xiaorong Li, Chong Feng, Guoqiang Wang,Qi Zhang, Xiaoxuan Qi, Lin Yu, Xingliang Zhang, Wenhai Feng, Wei Wu, Peng Gong, Ye Tao, Clara C. Posthuma, Eric J. Snijder, Alexander E. Gorbalenya*, Zhongzhou Chen*. Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Research, 2014;42(5):3464-77.
18. Xingliang Zhang, Lun Jiang, Guoqiang Wang, Lin Yu, Qi Zhang, Qi Xin, Wei Wu , Zhizhong Gong, Zhongzhou Chen*. Structural insights into the abscisic acid stereospecificity by the ABA receptors PYR/PYL/RCAR. PLoS One, 2013, vol 8, iss7, e67477
19. Wenli Tian, Lingyu Gao, Yazhou Zhao, Wenjun Peng* and Zhongzhou Chen*. Simultaneous determination of metronidazole, chloramphenicol and 10 sulfonamide residues in honey by LC–MS/MS. Anal. Methods, 2013, 5 (5), 1283-1288
20. Qi Zhang, Shankang Qi, Mingchu Xu, Lin Yu, Ye Tao, Zengqin Deng, Wei Wu, Zhongzhou Chen*, Jiemin Wong*. Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b. Cell Research, 2013, 23(2), 225-241
21. Xingliang Zhang, Qi Zhang, Qi Xin, Lin Yu, Zheng Wang, Wei Wu, Lun Jiang, Guoqiang Wang, Wenli Tian, Zengqin Deng, Yang Wang, Zhao Liu, Jiafu Long, Zhizhong Gong，Zhongzhou Chen*. Complex structures of the abscisic acid receptor PYL3/RCAR13 reveal a unique regulatory mechanism. Structure, 2012, 20(5), 780-790.
22. Lin Yu, Yang Wang, Shuo Huang, Jianjun Wang, Zengqin Deng, Qi Zhang, Wei Wu, Xingliang Zhang, Zhao Liu, Weimin Gong, Zhongzhou Chen*. Structural insights into a novel histone demethylase PHF8. Cell Research, 2010, 20(2), 166-73.
23. Zhongzhou Chen, Jianye Zang, Fei Lan, Xia Hong, Qin Wang, Shaodong Dai, Kirk Hansen, Yang Shi, and Gongyi Zhang. Structural basis of the recognition of a methylated histone tail by JMJD2A. PNAS, 2007, 104(26), 10818–10823.
24. Zhongzhou Chen, Jianye Zang, Johnathan Whetstine, Xia Hong, Foteini Davrazou, Tatiana G. Kutateladze, Michael Simpson, Qilong Mao, Cheol-Ho Pan, Shaodong Dai, James Hagman, Kirk Hansen, Yang Shi, Gongyi Zhang. Structural insights into histone demethylation by JMJD2 family members. Cell, 2006, 125(4), 691–702.
25. Zhong-Zhou Chen, Yan-Mei Li, Hai-Yan Wang, Jin-Tang Du, Yu-Fen Zhao. Theoretical study on the rearrangement of beta-OH and gamma-OH in ESI mass spectrometry by N-phosphorylation. Journal of Physical Chemistry A, 2004, 108(38), 7686-7690.
26. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao, Yu-Feng Tong, Jin-Feng Wang. Activity difference between alpha-COOH and beta-COOH in N-phosphorylaspartic acids. Journal of Organic Chemistry, 2003, 68(10), 4052-4058.
27. Zhong-Zhou Chen, Yan-Mei Li, Jing Ma, Bo Tan, Satoshi Inagaki, Yu-Fen Zhao, Comparing the activities of alpha-COOH and gamma-COOH in N-phosphoryl glutamic acid by theoretical study. Journal of Physical Chemistry A, 2002, 106(47), 11565-11569
28. Zhong-Zhou Chen, Yan-Mei Li, Xi Peng, Fu-Rong Huang, Yu-Fen Zhao. The Use of crude lipase in deprotection of C-terminal protecting groups. Journal of Molecular Catalysis B: Enzymatic, 2002,18(4-6), 243–249
29. Zhong-Zhou Chen, Shui-Bing Chen, Yi Chen, YanMei Li, Jing Chen, Yu-Fen Zhao. Negative-ion ESI mass spectrometry of N-phosphoryl amino acids and dipeptides. Rapid Commun. Mass Spectrom. 2002, 16: 790-796
30. ZhongZhou Chen, YuFeng Tong, ShuiBing Chen, YanMei Li, Yi Chen, YuFen Zhao, JinFeng Wang. Orientation of the peptide formation of N-phosphoryl amino acids in solution. Chinese Science Bull. 2002,47, 1866-1870
31. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao. Differentiation of alpha-COOH from beta-COOH in aspartic acids by N-phosphorylation. International Journal of Quantum Chemistry, 2001, 83, 41-51.
32. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yi Chen, Chang-Mei Cheng, Yu-Fen Zhao Differentiation of alpha-COOH from gamma-COOH in glutamic acids by N-phosphorylation. Journal of Molecular Structure: THEOCHEM, 2001, 574, 163-175.