个人简历

教育经历（按时间倒序排序）
1991/5 - 1996/5，美国佛罗里达大学，分子和细胞生物学，博士
1982/8 - 1985/8，北京农业大学，动物组织胚胎学，硕士
1978/3 - 1982/8，北京农业大学，兽医，学士
工作简历
1985/8-1991/5，北京农业大学实验动物研究所，研究所助理，讲师
1988/8-1989/8，美国国立动物病研究中心，访问学者
1996/5-1998/3，美国Oklahoma大学医学中心，博士后
1998/3 - 2000/1，美国Oklahoma医学研究基金会/哈佛休斯医学研究所，Research Associate
2000/1 - 2004/8，美国GENZYME公司，Scientist
2004/10 - 至今，中国科学院微生物研究所 研究员、博士生导师 目前任中国科学院微生物研究所分子病毒及生物制药中关村开放实验室主任、中国科学院病原微生物与免疫学重点实验室副主任、分子病毒中心主任、中国科学院微生物研究所生物安全三级实验室主任

研究领域

病毒与宿主细胞相互作用、动物病毒分子进化以及新型免疫增强剂和抗病毒药物

近期论文

1. W-J Chai #, J Li#, Q Shangguan, Q Liu, X-D Li, D-D Qi, X-M Tong, W-J Liu, X Ye*. 2018. Lnc-ISG20 inhibits influenza A virus replication by enhancing ISG20 expression. Journal of Virology. doi: doi:10.1128/JVI.00539-18
2. J Li, K Zhang, Q-Y Chen, X Zhang, Y-P Sun, Y-H Bi, S Zhang, J-Y Gu, J-R Li, Di Liu, W-J Liu*, J-Y Zhou*. 2018. Three Amino Acid Substitutions in the NS1 Protein change the Virus Replication of H5N1 Influenza Virus in Human Cells. Virology. doi: 10.1016/j.virol.2018.04.004
3. Y Li, L Sun*, W-N Zheng, Madina·M, J Li, Y-H Bi, H Wang, W-J Liu*, Luo T*. 2018. Phosphorylation and dephosphorylation of threonine 188 innucleoprotein is crucial for the replication of influenza A virus. Virology. doi: 10.1016/ j.virol.2018.05.002
4. C Chen, W-H Fan, J Li, W-N Zheng, S Zhang, L-Y Yang, D Liu, W-J Liu*, L Sun*. 2018. A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus. Front. Cell. Infect. Microbiol. 8:127. doi.org/10.3389/fcimb.2018.00127
5. Y-P Sun, J-W Jiang, P Tien, W-J Liu*, J Li*. 2018. IFN-λ: A new spotlight in innate immunity against influenza virus infection. Protein & Cell. doi: 10.1007/s13238-017-0503-6
6. Y-P Sun, J Li*, P Tien, George Fu Gao, W-J Liu*. 2018. Bunyavirales Ribonucleoproteins: the Viral Replication and Transcription Machinery. Critical Reviews in Microbiology. doi: 10.1080/1040841X.2018.1446901
7. J Li, J Lu, S Zhang, Wang J, F Liu, M Fang, X-F Duan*, W-J Liu. 2018. Differential Immune Response of Influenza A Virus-infected Dendritic Cells and Association with Autophagy. Future Virology. 10.2217/fvl-2017-0044.
8. W Liu#, J Li#, W-N Zheng, Y-L Shang, Z-D Zhao, S-S Wang, Y-H Bi, S Zhang, C-F Xu, Z-Y Duan, L-F Zhang, Y Wang, Z-F Jiang, W-J Liu*, L Sun*. 2017. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses. Elife, 6(8); 6. pii: e24425
9. J L#i, W-N Zheng#, L-D Hou#, C Chen, W-H Fan, H-R Qu, J-W Jiang, J Liu, George Fu Gao, J-Y Zhou, L Sun*, W-J Liu*. 2016. Differential Nucleocytoplasmic Shuttling of the Nucleoprotein of Influenza A Viruses and Association with Host Tropism. Cellular Microbiology. doi: 10.1111/cmi.12692
10.W-N Zheng#, S-S Cao#, C Chen#, J Li, Sh Zhang, J-W Jiang, Y-G Niu, W-H Fan, Y Li, Y-H Bi, George Fu Gao, L Sun*, W-J Liu*. 2016. Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I. Cellular Microbiology. doi:10.1111/cmi.12643.
11. J Li, C Chen, Gary W, W Dong, W-N Zheng, Y Li, L Sun, L-F Zhang, George Fu Gao, Y-H Bi, W-J Liu*. 2016. Cyclophilin A protects mice against infection by influenza A virus. Scientific reports 28978.
12. J-W Jiang, J Li*, W-H Fan, W-N Zheng, M Yu, C Chen, L Sun, Y-H Bi, C Ding, George Fu Gao, W-J Liu*. 2016. Robust Lys 63-linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection. Journal of Virology. pii: JVI.00549-16.
13. Y-G Niu, Y Liu, L-M Yang, H-R Qu, J Zhao, R-L Hu, J Li*, W-J Liu*. 2016. Evaluation of the immunogenicity of multi-epitope-based vaccine candidates against rabies adjuvant with Gp96. Virologica Sinica, 4; 31(2):168-75.
14. J Li, Y-H Rao, Q-L Sun, X-X Wu, J Jin, Y-H Bi, J Chen, F-M Lei, Q-Y Liu, Z-Y Duan, J-C Ma, George Fu Gao, D Liu, W-J Liu*. 2015. Identification of climate factors related to human infection with avian influenza A H7N9 and H5N1 viruses in China. Scientific reports, 18094, doi: 10.1038/srep18094
15. J Li, W-J Liu*. 2015. Diversity of the RNA polymerase in the H7N9 Influenza A Virus. Advances in Microbiology, 5: 661-667
16. J Li, T Qin, X-X Jia, A-H Deng, X Zang, W-H Fan, S-D Huo, T-Y Wen, W-J Liu*. 2015. Rapid Identification of Legionella Pathogenicity by Surface-Enhanced Raman Spectroscopy. Biomedical and Environmental Sciences, 2015; 28(6): 77-84
17. X-J Jia, Y-H Bi, J Li, Q Xie, H-C Yang*, W-J Liu*.2015. Cellular microRNA miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity, Scientific reports, 10651
18. K Zhang#, Z Wang#, G-Z Fan, J Wang, S-Y Gao, Y Li, L Sun, C-C Yin*, W-J Liu*. 2015. Two Polar Residues Within C-terminal Domain of M1 are Critical for the Formation of Influenza A Virus Matrix Layer, Cellular Microbiology (10)1111/cmi.12457
19. J Li, M Yu, W-N Zheng, W-J Liu*. 2015. Nucleocytoplasmic Shuttling of Influenza A Virus Proteins, Viruses 7, 2668-2682.
20. W-N Zheng, J Li, S-S Wang, S Cao, J-W Jiang, C Chen, C Ding, C Qin, X Ye, George Fu Gao, W-J Liu*. 2015. Phosphorylation controls the nuclear-cytoplasmic shuttling of influenza A virus nucleoprotein. Journal of Virology. 3(18). pii: JVI.00015-15.