个人简历

高山，英国牛津大学医学肿瘤学博士，中国农工民主党党员，中国科学院苏州生物医学工程技术研究所研究员，博士生导师，所学术委员会副主任。

研究领域

肿瘤分子基础和生物标志物；
 药物机理和生物标志物
 肿瘤免疫治疗技术和分子机理""

近期论文

1) Wang XD, Yang XH, Zhang C, Wang Y, Cheng TY, Duan LQ, Tong Z, Tan SG, Zhang HJ, Saw PE, Gu YM, Wang JH, Zhang YB, Shang LN, Liu YJ, Jiang SY, Yan BX, Li R, Yang Y, Yu J, Chen YZ, Gao GF#, Ye QN,Gao Shan#. 2020, Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy. Proceedings of the National Academy of Sciences of the United States of America. 117(12):6640-6650.
2) Li CY, Lu WL, Yang LG, Li ZW, Zhou XY, Guo R, Wang JQ, Wu ZB, Dong ZY, Ning G, Shi YJ, Gu YM, Chen P, Hao ZJ, Han TT, Yang MQ, Wang W, Huang XH, Li YX#, Gao Shan#, Hu RG#. 2020, MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3. National Science Review. 7:671-685.
3) Gao ZR, Xing KK, Zhang C, Qi JX, Wang L, Gao Shan#, Lai R#. 2019, Crystal structure and function of Rbj: A constitutively GTP-bound small G protein with an extra DnaJ domain. Protein Cell. 10(10):760-763.
4) Jiang SY, Wang XT, Song DL, Liu XJ, Gu YM, Xu ZY, Wang XD, Zhang XL, Ye QN, Tong Z, Yan BX, Yu J, Chen YZ, Sun MX, Wang Y, Gao Shan#. 2019, Cholesterol induces epithelial-to-mesenchymal transition of prostate cancer cells by suppressing degradation of EGFR through APMAP. Cancer Research. 79(12):3063-3075.
5) Cheng L, Yuan B, Ying SY, Niu C, Ma HX, Guan X, Yang XH, Teng Y, Lin J, Huang JJ, Jin R, Wu J, Liu B, Chang SH, Wang EQ, Zhang CX, Hou N, Cheng X, Xu DY, Yang X#, Gao Shan#, Ye QN#. 2019, PES1 is a critical component of telomerase assembly and regulates cellular senescence. Science Advances. 5(5): eaav1090.
6) Wang JH, Yang XH, Wang L, Zhao YH, Gu YM, Cheng TY, Huang KH, Yuan Y, Gao Shan#. 2018, The long noncoding RNA MYU promotes prostate cancer progression by mediating miR-184/c-Myc axis. Oncology Reports. 40(5):2814-2825.
7) Yang XH, Wang L, Li R, Zhao YH, Gu YM, Liu SY, Cheng TY, Huang KH, Yuan Y, Song DL, Gao Shan#. 2018, The long non-coding RNA PCSEAT exhibits an oncogenic property in prostate cancer and functions as a competing endogenous RNA that associates with EZH2. Biochemical and Biophysical Research Communications. 502(2):262-268.
8) Gu YM, Wang L, Zhao YH, Wang H, Ye QN, Gao Shan#. 2018, Association analysis between body mass index and genomic DNA methylation across 15 major cancer types. Journal of Cancer. 9(14):2532-2542.
9) Li L, Liang Y, Kang L, Liu Y, Gao Shan, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye QN. 2018, Transcriptional Regulation of the Warburg Effect in Cancer by SIX1. Cancer Cell. 497(2):633-638.
10) Li X, Jin J, Yang S, Xu W, Meng X, Deng H, Zhan J, Gao Shan#, Zhang H#. 2018, GATA3 acetylation at K119 by CBP inhibits cell migration and invasion in lung adenocarcinoma. Biochemical and Biophysical Research Communications. 4;497(2):633-638.