个人简历

景乃禾研究员1982年毕业于南京大学化学系，1988年在中科院上海生物化学研究所获博士学位。1989年赴日本理化学研究所从事博士后研究。1991年回国任中科院上海生化所课题组长，副研究员。1995年晋升为研究员，博士生导师。1992-1993年赴日本理化学研究所进行合作研究。1995年在法国遗传与分子细胞生物学研究所(IGBMC)进行合作研究。1996-1997年在德国马普生物物理化学研究所(Max-Planck Institute for Biophysical Chemistry)进行合作研究。2000年作为访问教授赴日本熊本大学进行合作研究。2003年作为访问教授赴日本大阪大学进行合作研究

研究领域

中枢神经系统是脊椎动物体内最复杂的系统之一。胚胎发育过程中，中枢神经系统的发育受到复杂而又次序严谨的调控。研究胚胎发育过程中神经干细胞的发生及其向各神经细胞亚型分化的分子机制，将有助于我们认识中枢神经系统的形成过程和神经系统疾病的发生发展进程，进而有助于我们提高针对各种神经退行性疾病的治疗手段。目前从事的主要研究方向包括：
1. 利用多能干细胞（胚胎干细胞和iPS细胞）、上胚层干细胞、外胚层干细胞和神经干细胞的体外分化系统，并结合小鼠早期胚胎发育模型，研究外部信号（BMP、Nodal、Wnt和FGF等信号通路）与内源因子（转录因子和表观遗传因子）在外胚层/神经外胚层模式建成中的功能及作用机制。
2. 建立高效的小鼠和人多能干细胞向特定亚型神经细胞定向分化系统，结合神经退行性疾病动物模型，研究神经退行性疾病的干细胞替代治疗及疾病特异的药物筛选细胞模型

近期论文

Jun Chen, Shengbao Suo, Patrick. P.L. Tam, Jing-Dong J. Han, Guangdun Peng*, Naihe Jing*. Using Geo-seq to undertake Low-input RNA-sequencing analysis of cell samples at defined geographical locations to enable mapping of the in situ position of single cells. Nature Protocol 2017; 12(3), 547-565.
Xiong-jun Wang, Yunbo Qiao, Minzhe M. Xiao, Lingbo Wang, Jun Chen, Wenjian Lv, Li Xu, Yan Li, Yumei Wang, Ming-dian Tan, Chao Huang, Jinsong Li, Ting C. Zhao, Zhaoyuan Hou*, Naihe Jing*, Y. Eugene Chin*. Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. Cell Reports 2017; 18: 933–946.
Lu Song, Jun Chen, Guangdun Peng, Ke Tang, NaiheJing*. Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Respond to Extrinsic BMP Signaling. J. Biol. Chem. 2016; 291(29):15212-25.
Guangdun Peng, Shengbao Suo, Jun Chen, Weiyang Chen, Chang Liu, Fang Yu, Ran Wang, Shirui Chen, Na Sun, Guizhong Cui, Lu Song, Patrick P. L. Tam, Jing-Dong Jackie Han*, Naihe Jing*. Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-Gastrula Mouse Embryo. Developmental Cell 2016; 36 (6), 681-697.
Yunbo Qiao, Xianfa Yang, Naihe Jing*. Epigenetic regulation of early neural fate commitment. Cell. Mol. Life Sci. 2016, 73(7):1399-1411.
Yunbo Qiao, Xianfa Yang, Naihe Jing*. Human neural development and human embryonic stem cell neural differentiation. Stem Cells: Basics and Clinical Translation (R.C. Zhao ed.) 2015, 1:189-199.
Lu Song, Na Sun, Guangdun Peng, Jun Chen, Jing-Dong Jackie Han, Naihe Jing*. Genome-wide ChIP-seq and RNA-seq analyses of Pou3f1 during mouse pluripotent stem cell neural fate commitment. Genomics Data 2015, 5:375-377.
Pingyu Liu, Xiaoyang Dou, Guangdun Peng, Jing-Dong Jackie Han, Naihe Jing*. Genome-wide analysis of histone acetylation dynamics during mouse embryonic stem cell neural differentiation. Genomics Data 2015, 5:15-16.
Chunmei Yue, Naihe Jing*. The promise of stem cells in the therapy of Alzheimer’s disease. Translational Neurodegeneration 2015, 4:8-12.
Ke Tang*, Guangdun Peng, Yunbo Qiao, Lu Song, Naihe Jing*. The Intrinsic Regulations in Neural Fate Commitment. Develop Growth Differ 2015, 57:109-120.
Wanqu Zhu, Xiao Yao, Yan Liang, Dan Liang, Lu Song, Naihe Jing, Jinsong Li and Gang Wang*. Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling. Development 2015, 142:465-476.
Wei Yue, Yuanyuan Li, Ting Zhang, Man Jiang, Yun Qian, Min Zhang, Nengyin Sheng, Su Feng, Ke Tang, Xiang Yu, Yousheng Shu, Chunmei Yue* and Naihe Jing*. ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models. Stem Cell Reports 2015, 5(5):776-90.
Yunbo Qiao, Xiongjun Wang, Ran Wang, Yuanyuan Li, Fang Yu, Xianfa Yang, Lu Song,Guoliang Xu, Y Eugene Chin & Naihe Jing*. AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation. Cell Discovery 2015, 1:15017.
Lingyu Li, Lu Song, Chang Liu, Jun Chen, Guangdun Peng, Ran Wang, Pingyu Liu, Ke Tang, Janet Rossant, and Naihe Jing*. Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling. J Mol Cell Biol 2015, 7(5):455-65.
Pingyu Liu, Xiaoyang Dou, Chang Liu, Lingbo Wang, Can Xing, Guangdun Peng, Jun Chen, Fang Yu, Yunbo Qiao, Lu Song, Yuxuan Wu, Chunmei Yue, Jinsong Li, Jing-Dong J. Han, Ke Tang, Naihe Jing*. Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate. Nature Communications 2015, 6:6830.
Fangzhi Tan, Cheng Qian, Ke Tang, Saber Mohamed Abd-Allah and Naihe Jing*. Inhibition of TGF-β Signaling can Substitute for Oct4 in Reprogramming and Maintain Pluripotency. J Biol Chem 2015, 290(7):4500-4511.
Yunbo Qiao, Ran Wang, Xianfa Yang, Ke Tang and Naihe Jing*. Dual Roles of Histone H3 Lysine 9 Acetylation in Human Embryonic Stem Cell Pluripotency and Neural Differentiation. J Biol Chem 2015, 290(4):2508-2520.
Qingqing Zhu, Lu Song, Guangdun Peng, Na Sun, Jun Chen, Ting Zhang, Nengyin Sheng, Wei Tang, Cheng Qian, Yunbo Qiao, Ke Tang, Jing-Dong Jackie Han, Jinsong Li, Naihe Jing*. The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways. Elife 2014, 3:e02224.
Xingxing Xu, Yonghui Tao, Xing Fu,Tao Yu, Yuanyuan Li, Kan Chen, Xiaoyan Ding, Kangcheng Ruan, Naihe Jing*, Ronggui Hu*. ZIP-seq: genome-wide mapping of trinucleotide repeats at single-base resolution. Journal of Molecular Cell Biology 2014, 6: 93–96
Lingyu Li, Chang Liu, Steffen Biechele, Qingqing Zhu, Lu Song, Fredrik Lanner, Naihe Jing and Janet Rossant*. Location of transient ectodermal progenitor potential in mouse development. Development 2013, 140:4533-4543.