个人简历

1991-1995年就读于吉林大学获学士学位，1995-2000年就读于中国科学院上海生化与细胞所获博士学位，2000-2007年在哈佛医学院从事博士后工作。2007年受聘于中科院上海生科院生化与细胞所，任研究员、博导。长期从事肺癌发病分子机理的研究，取得一系列原创性的科研成果。迄今为止发表论文130余篇，其中作为第一或通讯作者在Nature, Cancer Cell, Nature Genetics, Journal of Clinical Investigations, Journal of Clinical Oncology, PNAS 等期刊发表论文60余篇。荣获奖励包括上海市“浦江人才计划”, 中科院上海分院系统杰出青年科技创新人才, 国家杰出青年基金, 第七届上海青年科技英才, 上海市优秀学术带头人, 上海医学科技奖二等奖,上海市科技进步二等奖等。现任《中华肿瘤杂志》、Thoracic Cancer、《中国肺癌杂志》等期刊编委；中国抗癌协会上海市分子靶向治疗及免疫治疗委员会副主委，中国抗癌协会肿瘤转移专业委员会、中国抗癌协会肺癌专业委员会、中国医疗保健国际交流促进会胸部肿瘤分会委员。

研究领域

肺癌发病的分子机理

近期论文

Yao S, Huang H, Han X, Ye Y, Qin Z, Zhao G, Li F, Hu G, Hu L*, Ji H*. (2019). Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation. Oncogene 2019 Jul 18. doi: 10.1038/s41388-019-0889-0. [Epub ahead of print]
Wang Y, Zhang J, Ren S, Sun D, Huang HY, Wang H, Jin Y, Li F, Zheng C, Yang L, Deng L, Jiang Z, Jiang T, Han X, Hou S, Guo C, Li F, Gao D, Qin J, Gao D, Chen L, Lin SH, Wong KK, Li C*, Hu L*, Zhou C*, Ji H*. Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors. Cell Reports 2019;28(2):512-525.e6.
Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, Zhou Q, Zeng G, Hu X, Yu L, Zhou S, Tong X, Huang H, Chen H, Liu Q, Liu W, Zhang G, Zeng M, Zhou G, He Q, Ji H*, Chen L*. Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 2019;10(1):1665.
Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G, Ji H*, Zhou B*. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet 2019;51(4):728-738.
Zhao G, Gong L, Su D, Jin Y, Guo C, Yue M, Yao S, Qin Z, Ye Y, Tang Y, Wu Q, Zhang J, Cui B, Ding Q, Huang H, Hu L, Chen Y, Zhang P, Hu G, Chen L, Wong KK, Gao D*, Ji H*. Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1. J Clin Invest 2019;129(3):972-987.
Y. Wang, T. Jiang, Z. Qin, J. Jiang, Q. Wang, S. Yang, C. Rivard, G. Gao, T. L. Ng, M.M. Tu, H. Yu, H. Ji*, C. Zhou*, S. Ren*, J. Zhang, P. Bunn, R. C. Doebele, D. R. Camidge, F. R. Hirsch. HER2 exon 20 insertions in non-small-cell lung cancer are sensitive to the irreversible pan-HER receptor tyrosine kinase inhibitor pyrotinib. Annals of Oncology 2019 Mar 1;30(3):447-455.
Wu Q, Tian Y, Zhang J, Tong X, Huang H, Li S, Zhao H, Tang Y, Yuan C, Wang K, Fang Z, Gao L, Hu X, Li F, Qin Z, Yao S, Chen T, Chen H, Zhang G, Liu W, Sun Y, Chen L, Wong KK, Ge K, Chen L*, Ji H*. In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis. Proc Natl Acad Sci U S A 2018;115(17):E3978-E3986.
Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H*. YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation. Cancer Res 2017;77(21):5769-5781.
Hou S, Han X, Ji H*. Squamous Transition of Lung Adenocarcinoma and Drug Resistance. Trends in Cancer 2016;2(9):463-466.
Hou S, Zhou S, Qin Z, Yang L, Han X, Yao S, Ji H*. Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma. Am J Pathol 2017;187(5):954-962.
Li F, Fang Z, Zhang J, Li C, Liu H, Xia J, Zhu H, Guo C, Qin Z, Li F, Han X, Wang Y, Feng Y, Wang Y, Zhang W, Wang Z, Jin Y, Sun Y, Wei W, Zeng R, Chen H, Ji H*. Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma. Cell Res 2016;26(10):1149-1164.
Zhang W, Gao Y, Li F, Tong X, Ren Y, Han X, Yao S, Long F, Yang Z, Fan H, Zhang L*, Ji H*. YAP promotes malignant progression of Lkb1-deficient lung adenocarcinoma through downstream regulation of survivin. Cancer Res 2015;75(21):4450-4457.
Li F, Han X, Li F, Wang R, Wang H, Gao Y, Wang X, Fang Z, Zhang W, Yao S, Tong X, Wang Y, Feng Y, Sun Y, Li Y, Wong KK, Zhai Q, Chen H*, Ji H*. LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response. Cancer Cell 2015;27(5):698-711.
Gao Y, Zhang W, Han X, Li F, Wang X, Wang R, Fang Z, Tong X, Yao S, Li F, Feng Y, Sun Y, Hou Y, Yang Z, Guan K, Chen H, Zhang L*, Ji H*. YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression. Nat Commun 2014;5:4629.
Wang Y, Gao J, Guo X, Tong T, Shi X, Li L, Qi M, Wang Y, Cai M, Jiang J, Xu C*, Ji H*, Wang H*. Regulation of EGFR nanocluster formation by ionic protein-lipid interaction. Cell Res 2014;24(8):959-976.
Wang R, Wang L, Li Y, Hu H, Shen L, Shen X, Pan Y, Ye T, Zhang Y, Luo X, Zhang Y, Pan B, Li B, Li H, Zhang J, Pao W, Ji H*, Sun Y*, Chen H*. FGFR1/3 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Non-Small Cell Lung Cancer. Clin Cancer Res 2014;20(15):4107-4114.
Han X, Li F, Fang Z, Gao Y, Li F, Fang R, Yao S, Sun Y, Li L, Zhang W, Ma H, Xiao Q, Ge G, Fang J, Wang H, Zhang L, Wong KK, Chen H, Hou Y, Ji H*. Transdifferentiation of Lung Adenocarcinoma in mice with Lkb1 Deficiency to Squamous Cell Carcinoma. Nat Commun 2014;5:3261.
Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, He F, Wang Y, Zhang Z, Wang W, Wang X, Guo T, Li P, Zhao Y, Ji H*, Zhang L*, Zhou Z*. A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer Cell 2014;25:166-180.
Fang R, Zheng C, Sun Y, Han X, Gao B, Li C, Liu H, Wong KK, Liu XY*, Chen H*, Ji H*. Brief Report: Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas. J Thorac Oncol 2014;9(2):254-258.
Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z, Li F, Chen H, Zhou Z*, Zhang L*, Ji H*. VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Res 2014;24(3):331-343.