个人简历

中国科学院宁波材料技术与工程研究所研究员，博士生导师，党委委员，所学术委员会副主任，所属慈溪生物医学工程研究所 所长。江西南昌人，中共党员，中科院人才，国家JQ。\r
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1994-1998年 南昌大学化学系 本科 (优秀毕业生)\r
1998-2003年 中科院长春应化所-电分析化学国家重点实验室理学博士 指导老师 汪尔康院士／李壮研究员（获中科院彭荫刚奖学金）\r
2004-2005年 德国马尔堡大学 博士后（Norbert A Hampp教授课题组）\r
2005-2006年 美国加州理工学院 博士后（1999年诺贝尔化学奖获得者Ahmed H. Zewail教授课题组）\r
2006-2009年 美国西北大学医学院 助理研究员（Gayle E. Woloschak教授课题组）\r
2009-2018年 中国科学院宁波材料技术与工程研究所 纳米事业部 研究员 (独立团队负责人)\r
2019-至今 中国科学院宁波材料技术与工程研究所 慈溪生物医学工程研究所 所长

研究领域

""多功能造影剂；危害性物质传感检测""""

近期论文

Zheyu Shen, Ting Liu, Zhen Yang, Zijian Zhou, Wei Tang, Wenpei Fan*, Yijing Liu, Jing Mu, Ling Li, Vladimir I. Bregadze, Swadhin K. Mandal, Anna A. Druzina, Zhenni Wei, Xiaozhong Qiu*, Aiguo Wu*, Xiaoyuan Chen*. Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma. Biomaterials 2020, 235, 119783. \r
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Zhenni Wei, Zhenqi Jiang, Chunshu Pan, Jianbi Xia, Kaiwei Xu, Ting Xue, Bo Yuan, Ozioma Udochukwu Akakuru, Chengjie Zhu, Guilong Zhang, Zheng Mao, Xiaozhong Qiu*, Aiguo Wu*, Zheyu Shen*. Ten-Gram-Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis. Small 2020, 1906870, DOI: 10.1002/smll.201906870 . \r
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Zheyu Shen, Wenpei Fan*, Zhen Yang, Yijing Liu, Vladimir I. Bregadze, Swadhin K. Mandal, Bryant C. Yung, Lisen Lin, Ting Liu*, Wei Tang, Lingling Shan, Yuan Liu, Shoujun Zhu, Sheng Wang, Weijing Yang, L. Henry Bryant, Duong T. Nguyen, Aiguo Wu*, Xiaoyuan Chen*. Exceedingly Small Gadolinium Oxide Nanoparticles with Remarkable Relaxivities for Magnetic Resonance Imaging of Tumors. Small 2019, 1903422, DOI: 10.1002/smll.201903422.\r
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Chuang Liu, Jie Xing, Ozioma Udochukwu Akakuru, Lijia Luo, Shan Sun, Ruifen Zou, Zhangsen Yu, Qianlan Fang, and Aiguo Wu*. Nanozymes-Engineered Metal−Organic Frameworks for Catalytic Cascades-Enhanced Synergistic Cancer Therapy. Nano Letters, 2019, 19, 5674−5682.\r
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Zhenqi Jiang, Yinjie Wang, Li Sun, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Li, Juan Li∗, Aiguo Wu∗, Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo, Biomaterials, 2019, 197, 41-50.\r
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Zheyu Shen, Ting Liu, Yan Li, Joseph Lau, Zhen Yang, Wenpei Fan, Zijian Zhou, Changrong Shi, Chaomin Ke, Vladimir I. Bregadze, Swadhin K. Mandal, Yijing Liu*,Zihou Li, Ting Xue, Guizhi Zhu, Jeeva Munasinghe, Gang Niu, Aiguo Wu*, and Xiaoyuan Chen*, Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors, ACS Nano., 2018, 12, 11355−11365.\r
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Zheyu Shen, Jibin Song, Zijian Zhou, Bryant C. Yung, Maria A. Aronova, Yan Li, Yunlu Dai, Wenpei Fan, Yijing Liu*, Zihou Li, Huimin Ruan, Richard D. Leapman, Lisen Lin, Gang Niu, Xiaoyuan Chen*, Aiguo Wu*, Dotted Core-Shell Nanoparticles with Superhigh r1 and Very Low r2/r1 for T1-Weighted MRI of Tumors, Adv Mater., 2018, 30, 1803163.\r
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Chuang Liu, Lijia Luo, Leyong Zeng, Jie Xing, Yuanzhi Xia, Shan Sun, Luyun Zhang, ZheYu, Junlie Yao, Zhangsen Yu, Ozioma Udochukwu, Akakuru, Madiha Saeed, Aiguo Wu. *, Porous gold nanoshells on functional NH2-MOFs: facile synthesis and designable platforms for cancer multiple therapy. Small, 2018, 14, 1801851. (Featutred in Front Cover, Top 10(7) in Small in 2018/08)\r
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Zhenqi Jiang1, Yuchen Tian1, Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Juan Li*, Jian Yang, and Aiguo Wu*, pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time, Biomaterials, 2018, 170, 70-81.\r
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Zheyu Shen, Jibin Song, Bryant C. Yung, Zijian Zhou*, Aiguo Wu*, and Xiaoyuan Chen*, Emerging Strategies of Cancer Therapy Based on Ferroptosis, Adv. Mater., 2018, 30, 201704007. (Featured in Frontspecies, Invited Review)\r
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Qiuyu Gong, Ruifen Zou, Jie Xing, Lingchao Xiang, Renshuai Zhang, and Aiguo Wu*. An Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine, Adv. Sci., 2018, 5, 1700664.\r
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Yuanzhi Xia#, Xuehua Ma #, Junhua Gao, Guoxin Chen, Zihou Li, Xiaoxia Wu, Zhangsen Yu, Jie Xing, Li Sun, Huimin Ruan, Lijia Luo，Lingchao Xiang, Chen Dong, Wenzhi Ren, Zheyu Shen *, Aiguo Wu*. A Flexible Caterpillar-Like Gold Nanoparticle Assemblies with Ultra-Small Nanogaps for Enhanced Dual-Modal Imaging and Photothermal Therapy, Small, 2018, 14, 1800094.\r
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Zheyu Shen, Tianxiang Chen, Xuehua Ma, Wenzhi Ren, Zijian Zhou, Guizhi Zhu, Ariel Zhang, Yijing Liu, Jibin Song,* Zihou Li, Huimin Ruan, Wenpei Fan, Lisen Lin, Jeeva Munasinghe, Xiaoyuan Chen,* Aiguo Wu*. Multifunctional Theranostic Nanoparticles Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for T1‑Weighted Magnetic Resonance Imaging and Chemotherapy, ACS Nano, 2017, 11, 10992−11004.\r
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Juan Li#, Yuchen Tian#, Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lin gchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang, Aiguo Wu *, Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging, Biomaterials, 2017, 116, 106-117.\r
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Zheyu Shen, Aiguo Wu*, and Xiaoyuan Chen*. Current detection technologies for circulating tumor cells. Chem. Soc. Rev., 2017, 46, 2038-2056. (Invited Review, Front Inside Cover)\r
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Leyong Zeng, Yuanwei Pan, Ruifen Zou, Jinchao Zhang, Ying Tian, Zhaogang Teng, Shouju Wang, Wenzhi Ren, Xueshan Xiao, Jichao Zhang, Lili Zhang, Aiguo Li, Guangming Lu*and Aiguo Wu*. 808 nm-excited upconversion nanoprobes with low heating effect for targeted magnetic resonance imaging and high-efficacy photodynamic therapy in HER2-overexpressed breast cancer. Biomaterials, 2016, 103, 116-127.\r
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Zheyu Shen, Hao Wu, Sugeun Yang, Xuehua Ma, Zihou Li, Mingqian Tan* and Aiguo Wu*. A novel Trojan-horse targeting strategy to reduce the non-specific uptake of nanocarriers by noncancerous cells. Biomaterials, 2015, 70, 1-11.\r
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Lulu Pan; Shan Sun; Aidi Zhang; Kai Jiang; Ling Zhang; Chaoqing Dong; Qing Huang; Aiguo Wu and Hengwei Lin*, Truly fluorescent excitation-dependent carbon dots and their applications in multicolor cellular imaging and multidimensional sensing, Advanced Materials, 2015, 27, 7782-7787.\r
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Leyong Zeng, Yuanwei Pan, Ying Tian, Xin Wang, Wenzhi Ren, Shouju Wang, Guangming Lu* and Aiguo Wu*. Doxorubicin-loaded NaYF4: Yb/Tm-TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers. Biomaterials, 2015, 57, 93-106.\r
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Ling'e Zhang, Leyong Zeng*, Yuanwei Pan, Song Luo, Wenzhi Ren, An Gong, Xuehua Ma, Hongze Liang, Guangming Lu* and Aiguo Wu*. Inorganic photosensitizer coupled Gd-based upconversion luminescent nanocomposites for in vivo magnetic resonance imaging and near-infrared-responsive photodynamic therapy in cancers. Biomaterials, 2015, 44, 82-90.