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张于
2023-05-17 10:34
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  • 张于 - 副研究员 硕导--张于-个人资料

近期热点

资料介绍

个人简历


2015年6月-2016年6月,美国北卡罗莱纳大学教堂山分校药学院访问学者
2015年1月-至今,中国科学院昆明植物研究所,硕士研究生导师
2014年1月-至今,中国科学院昆明植物研究所副研究员
2010年7月-2014年1月,中国科学院昆明植物研究所助理研究员
2005年9月-2010年7月,中国科学院昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室,获理学博士学位
2001年09-2005年7月,贵州大学化学系,获理学学士学位

研究领域


主要研究方向为以植物中新颖结构、具有重要生理功能(抗肿瘤、抗病毒)的活性生物碱为研究目标,利用植物化学、化学合成、生物学等手段探讨其结构、活性以及作用机制(靶点)等,从中寻找药物先导和候选结构。此外,亦开展量子计算化学方法在复杂天然产物结构鉴定、绝对构型确定中的应用工作

近期论文


1. Xin Fang, Ying-Tong Di, Yu Zhang, Zhi-Ping Xu, Yang Lu, Qian-Qian Chen, Qi-Tai Zheng, Xiao-Jiang Hao*. Unprecedented quassinoids with promising biological activity from Harrisonia perforate. Angew. Chem. Int. Ed., 2015, 54, 5592-5595.
2. Ming-Ming Cao, Sheng-Dian Huang, Ying-Tong Di, Chun-Mao Yuan, Guo-Ying Zuo, Yu-Cheng Gu, Yu Zhang*, Xiao-Jiang Hao*. Myrifabine, the first dimeric Myrioneuron alkaloid from Myrioneuron faberi. Org. Lett., 2014, 16, 528-531.
3. Sheng-Dian Huang#, Yu Zhang#, Ming-Ming Cao, Ying-Tong Di, Gui-Hua Tang, Zong-Gen Peng, Jiang-Dong Jiang, Hong-Ping He*, Xiao-Jiang Hao*. Myriberine A, a new alkaloid with an unprecedented heteropentacyclic skeleton from Myrioneuron faberi. Org. Lett., 2013, 15, 590-593.
4. Yu Zhang, Ying-Tong, Di, Qiang Zhang, Shu-Zhen Mu, Cheng-jian Tan, Xin Fang, Hong-Ping He, Shun-Lin Li and Xiao-Jiang Hao*. Daphhimalenine A, a New Alkaloid with an Unprecedented Skeleton, from Daphniphyllum himalense. Org. Lett., 2009, 11, 5414–5417.
5. Chuan-Mao Yuan#, Yu Zhang#, Gui-Hua Tang, Shun-Lin Li, Ying-Tong Di, Li Hou, Jie-Yun Cai, Hui-Ming Hua*, Hong-Ping He*, Xiao-Jiang Hao*. Senegalensions A–C, three limonoids from Khaya senegalensis. Chem. Asian J. 2012, 7, 2024-2027.
6. Yu Zhang, Ying-Tong, Di, Hong-Ping He, Shi-Fei Li, Yang Lu, Ning-Bo Gong, and Xiao-Jiang Hao*. Daphmalenines A and B, two New Alkaloids with unusual skeletons from Daphniphyllum himalense. Eur. J. Org. Chem., 2011, 2011, 4103–4107.
7. Yu Zhang, Ying-Tong Di, Shu-Zhen Mu, Chun-Shun Li, Qiang Zhang, Cheng-Jian Tan, Zhen Zhang, Xin Fang and Xiao-Jiang Hao*. Dapholdhamines A-D, Alkaloids from Daphniphyllum oldhami J. Nat. Prod., 2009, 72, 1325–1327.
8. Yu Zhang, Hong-Ping He, Ying-Tong Di, Shu-Zhen Mu, Yue-Hu Wang, Jun-Song Wang, Chun-Shun Li, Ning-Chuan Kong, Suo Gao and Xiao-Jiang Hao*. Paxiphyllines A and B, New alkaloids from Daphniphyllum paxianum. Tetrahedron Lett. 2007, 48, 9104–9107.
9. Yu Zhang, Ling-Li Guo, Guang-Mei Yang, Feng Guo, Ying-Tong Di, Shun-Lin Li, Duo-Zhi Chen, Xiao-Jiang Hao*. New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa. Fitoterapia 2015, 100, 150-155.
10. Yu Zhang, Ying-Tong Di, Hai-Yang Liu, Chun-Shun Li, Cheng-Jian Tan, Qiang Zhang, Xin Fang, Shun-Lin Li and Xiao-Jiang Hao*. Three new alkaloids, Paxiphyllines C-E, from Daphniphyllum paxianum. Helv. Chim. Acta 2008, 91, 2153–2158.
11. Yu Zhang, Hong-Ping He, Ling-Li Guo, Shi-Fei Li, Ying-Tong, Di, and Xiao-Jiang Hao*. Daphhimalenines C and D, new alkaloids from Daphniphyllum himalense. Z. Naturforssch. 2012, 67b, 407-410.
12. Xiao-Hui Li,# Yu Zhang#, Jia-Hui Zhang, Xiao-Nian Li, Ming-Ming Cao, Ying-Tong Di, Zong-Gen Peng, Jian-Dong Jiang, Xiao-Jiang Hao*. Myritonines A-C, Alkaloids from Myrioneuron tonkinensis based on a novel hexacyclic skeleton. J. Nat. Prod., 2016, 79, 1203-1207.
13. Fang Liu#, Yu Zhang#, Qian-Yun Sun, Fu-Mei Yang, Wei Gu, Jun Yang, Hong-Mei Niu, Yue-Hu Wang*, Chun-Lin Long*. Diarylheptanoids and phenylphenalenones from Musa itinerans fruits. Phytochemistry, 2014, 103, 171-177.
14. Ying Yan, Jian-Xin Zhang, Tao Huang, Xin-Ying Mao, Wei Gu, Hong-Ping He, Ying-Tong Di, Shun-Lin Li, Duo-Zhi Chen, Yu Zhang*, and Xiao-Jiang Hao*. Bioactive limonoid constituents of Munronia henryi. J. Nat. Prod., 2015, 78, 811-821.
15. Yan-Hui Fu, Ying-Tong Di, Hong-Ping He, Shun-Lin Li, Yu Zhang*, Xiao-Jiang Hao*. Anguistifonines A and B, cytotoxic bisindole alkaloids from Bousigonia angustifolia. J. Nat. Prod., 2014, 77, 57-62.
16. Ling-Li Guo, Hong-Ping He, Ying-Tong Di, Shi-Fei Li, Yuan-Yuan Cheng, Wei Yang, Yan Li, Jian-Ping Yu, Yu Zhang*, Xiao-Jiang Hao*. Indole alkaloids from Ervatamia chinensis. Phytochemistry, 2012, 74, 140-145.
17. Gui-Hua Tang, Hong-Ping He, Yu-Cheng Gu, Ying-Tong Di, Yue-Hu Wang, Shi-Fei Li, Shun-Lin Li, Yu Zhang*, Xiao-Jiang Hao*. 3,4-seco-Diterpenoids from Trigonostemon flavidus. Tetrahedron, 2012, 68, 9679-9684.
18. Yan-Hui Fu, Hong-Ping He, Ying-Tong Di, Shun-Lin Li, Yu Zhang*, Xiao-Jiang Hao*. Mekongenines A and B, two new alkaloids from Bousigonia mekongensis. Tetrahedron Lett., 2012, 53, 3642-3646.
19. Cheng-Jian Tan, Yue-Hu Wang, Ying-Tong Di, Hong-Ping He, Shu-Zhen Mu, Shi-Fei Li, Yu Zhang*, Xiao-Jiang Hao*. Daphnioldhamine A, a novel alkaloid from Daphniphyllum oldhami. Tetrahedron Lett., 2012, 53, 2588-2591.
20. Lei Wang, Hong-Ping He, Ying-Tong Di, Yu Zhang*, Xiao-Jiang Hao*. Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus. Tetrahedron Lett., 2012, 53, 1576-1578.

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