个人简历

中国科学院昆明植物研究所，研究员，天然药物化学前沿交叉创新大研究团队负责人，课题组长，博士生导师。2019年入选国家“万人计划”科技创新领军人才，2016年入选科技部“中青年科技创新领军人才”，2015年获得国家基金委“优秀青年基金”。\r
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2013/02-至今, 中国科学院昆明植物研究所，植物化学与西部植物资源持续利用国家重点实验室，研究员，课题组长，博士生导师 \r
2011/01-2013/01，美国斯克里普斯研究所 (The Scripps Research Institute), 化学系，研究助理(Research Associate) \r
2008/04-2010/12，美国威斯康星大学麦迪逊分校 (University of Wisconsin -Madison)，药学院，博士后\r
2007/09-2008/03，香港赛马会中药研究院，中药学研究室，研究人员 (Scientist) \r
2004/09-2007/07，中国科学院昆明植物研究所，植物化学，博士 \r
2001/09-2004/07，中国科学院成都生物研究所，天然产物化学，硕士 \r
1997/09-2001/07，陕西师范大学化学系，本科/理学学士

研究领域

""利用我国特有的植物及微生物资源，紧紧围绕创新药物研发，就天然产物的发现、生物合成和合成生物学等内容开展如下三个方面的研究：（1）基因组导向、天然有机化学、生物合成化学驱动的特殊放线菌、真菌源天然药物先导化合物的发现；（2）植物源、微生物源活性天然产物生物合成途径中新颖的酶催化机制研究；（3）活性植物源、微生物源天然产物的合成生物学研究——合成途径的设计、构建、表达与优化。""""

近期论文

Yijun Yan, Jing Yang, Li Wang, Dongdong Xu, Zhiyin Yu, Xiaowei Guo, Geoff P. Horsman, Shuangjun Lin, Meifeng Tao, Sheng-Xiong Huang*. Biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase. Chem. Sci. 2020, 11, 3959-3964. DOI: 10.1039/C9SC05766H\r
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Jie Yuan, Li Wang, Jinqiu Ren, Jian-Ping Huang, Mingming Yu, Jun Tang, Yijun Yan, Jing Yang*, Sheng-Xiong Huang*. Antibacterial pentacyclic polyketides from a soil-derived Streptomyces. J. Nat. Prod. 2020, 83, 1919-1924. DOI: 10.1021/acs.jnatprod.0c00161\r
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Ke-Na Feng, Yan-Long Yang, Yu-Xing Xu, Yue Zhang, Tao Feng, Sheng-Xiong Huang*, Ji-Kai Liu*, Ying Zeng*. A hydrolase-catalyzed cyclization forms the fused bicyclic β-lactone in vibralactone. Angew. Chem. Int. Ed. Engl. 2020, 59, 7209-7213. DOI: 10.1002/anie.202000710\r
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Xiaoxin Zhuang, Zhiyan Wang, Chenghui Peng, Can Su, Congting Gao, Yongjiang Wang, Shengxiong Huang*, Chongxi Liu*. Characterization of Streptomyces piniterrae sp. nov. and identification of the putative gene cluster encoding the biosynthesis of heliquinomycins. Microorganisms 2020, 8, 495. DOI: 10.3390/microorganisms8040495\r
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Xiao-Yan Ma, Jian-Ping Huang, Jing Yang, Xingyong Liu, Xinjun Hu, Sheng-Xiong Huang*. Concise and efficient syntheses of methyl 4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate and hygrine. Can. J. Chem. 2020, 98, 191-193. DOI: 10.1139/cjc-2019-0442\r
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Feng-Xian Yang, Jian-Ping Huang, Zhixiang Liu, Zhiyan Wang, Jing Yang, Jun Tang, Zhiyin Yu, Yijun Yan, Guoyin Kai*, Sheng-Xiong Huang*. Benwamycins A–G, trialkyl-substituted benzene derivatives from a soil-derived Streptomyces. J. Nat. Prod. 2020, 83, 111-117. DOI: 10.1021/acs.jnatprod.9b00903\r
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Zhiyin Yu, Hao Jiang, Li Wang, Feng-Xian Yang, Jian-Ping Huang, Chongxi Liu, Xiaowei Guo, Wensheng Xiang*, Sheng-Xiong Huang*. Dimeric pimprinine alkaloids from soil-derived Streptomyces sp. NEAU-C99. Front. Chem. 2020, 8, 95. DOI: 10.3389/fchem.2020.00095\r
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Jian-Ping Huang, Chengli Fang, Xiaoyan Ma, Li Wang, Jing Yang, Jianying Luo, Yijun Yan, Yu Zhang*, Sheng-Xiong Huang*. Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation. Nat. Commun. 2019, 10, 4036. DOI: 10.1038/s41467-019-11987-z\r
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Lei Wang, Li Wang, Zhi Zhou, Yong-Jiang Wang, Jian-Ping Huang, Ya-Tuan Ma, Yang Liu, Sheng-Xiong Huang*. Cangumycins A−F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces. Chin. J. Nat. Med. 2019, 17, 982-987. DOI: 10.1016/S1875-5364(19)30121-9\r
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Can Su, Yijun Yan, Xiaowei Guo, Jianying Luo, Chongxi Liu, Zhouxin Zhang, Wen-Sheng Xiang, Sheng-Xiong Huang*. Characterization of the N-methyltransferases involved in the biosynthesis of toxoflavin, fervenulin and reumycin from Streptomyces hiroshimensis ATCC53615. Org. Biomol. Chem. 2019, 17, 477-481. DOI: 10.1039/C8OB02847H\r
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Xiaowei Guo, Jidong Wang, Can Su, Chongxi Liu, Xiao-Yan Ma, Zhiyin Yu, Jiansong Li, Xiangjing Wang, Wensheng Xiang*, Sheng-Xiong Huang*. A unique spiro-β-triazinedione-γ-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis. Org. Chem. Front. 2019, 6, 3215-3219. DOI: 10.1039/C9QO00742C\r
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Chongxi Liu, Xiaoxin Zhuang, Zhiyin Yu, Zhiyan Wang, Yongjiang Wang, Xiaowei Guo, Wensheng Xiang*, Sheng-Xiong Huang*. Community structures and antifungal activity of root-associated endophytic Actinobacteria of healthy and diseased soybean. Microorganisms 2019, 7, 243. DOI: 10.3390/microorganisms7080243\r
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Xin He, Yongjiang Wang, Rong-Hua Luo, Liu-Meng Yang, Li Wang, Dale Guo, Jing Yang, Yun Deng, Yong-Tang Zheng, Sheng-Xiong Huang*. Dimeric pyranonaphthoquinone glycosides with anti-HIV and cytotoxic activities from a soil-derived Streptomyces. J. Nat. Prod. 2019, 82, 1813-1819. DOI: 10.1021/acs.jnatprod.9b00022\r
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Zhouxin Zhang, Pei Cao, Ning-Ning Shang, Jing Yang, Li Wang, Yijun Yan, Sheng-Xiong Huang*. Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces. Org. Chem. Front. 2019, 6, 177-182. DOI: 10.1039/c8qo01107a\r
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Miao Dong, Pei Cao*, Ya-Tuan Ma, Jianying Luo, Yijun Yan, Rong-Tao Li, Sheng-Xiong Huang*. A new actinomycin Z analogue with an additional oxygen bridge between chromophore and β-depsipentapeptide from Streptomyces sp. KIB-H714. Nat. Prod. Res. 2019, 33, 219-225. DOI: 10.1080/14786419.2018.1443097\r
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Zi-Jun Xiong, Jianping Huang, Yijun Yan, Li Wang, Zhiyan Wang, Jing Yang, Jianying Luo, Jie Li, Sheng-Xiong Huang*. Isolation and biosynthesis of labdanmycins: Four new labdane diterpenes from endophytic Streptomyces. Org. Chem. Front. 2018, 5, 1272-1279. DOI: 10.1039/C8QO00085A\r
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Feng-Xian Yang, Guan-Xiong Hou, Jianying Luo, Jing Yang,Yijun Yan, Sheng-Xiong Huang*. New phenoxazinone-related alkaloids from strain Streptomyces sp. KIB-H1318. J. Antibiot. 2018, 71, 1040-1043. DOI: 10.1038/s41429-018-0099-y\r
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Shao-Hua Xu, Wen Xu, Li Wang, Yi-Kao Hu, Jin-Ping Liu, Yan Zhao, Meng-Jia Li, Feng Li, Sheng-Xiong Huang*, Yong Zhao*. New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense. Fitoterapia 2018, 131, 141-145. DOI: 10.1016/j.fitote.2018.10.010\r
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Tong Zhang, Li Wang, De-Hua Duan, Yi-Hao Zhang, Sheng-Xiong Huang*, Ying Chang*. Cytotoxicity-guided isolation of two new phenolic derivatives from Dryopteris fragrans (L.) Schott. Molecules 2018, 23, 1652. DOI: 10.3390/molecules23071652\r
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Ning-Ning Shang, Zhouxin Zhang, Jian-Ping Huang, Li Wang, Jianying Luo, Jing Yang, Teng Peng, Yijun Yan, Ya-Tuan Ma, Sheng-Xiong Huang*. Glycosylated piericidins from an endophytic Streptomyces with cytotoxicity and antimicrobial activity. J. Antibiot. 2018, 71, 672-676. DOI: 10.1038/s41429-018-0051-1\r
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Li Wang, Jing Yang, Ling-Mei Kong, Jun Deng, Zijun Xiong, Jianping Huang, Jianying Luo, Yijun Yan, Yikao Hu, Xiao-Nian Li, Yan Li, Yong Zhao*, Sheng-Xiong Huang*. Natural and semisynthetic tigliane diterpenoids with new carbon skeletons from Euphorbia dracunculoides as a Wnt signaling pathway inhibitor. Org. Lett. 2017, 19, 3911-3914. DOI: 10.1021/acs.orglett.7b01813\r
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Ruimin Yang, Jing Yang, Li Wang, Jian-Ping Huang, Zijun Xiong, Jianying Luo, Mingming Yu, Yijun Yan, Sheng-Xiong Huang*. Lorneic acid analogues from an endophytic Actinomycete. J. Nat. Prod. 2017, 80, 2615-2619. DOI: 10.1021/acs.jnatprod.7b00056\r
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Rui-Min Yang, Xiu-Lei Zhang, Li Wang, Jian-Ping Huang, Jing Yang, Yi-Jun Yan, Jian-Ying Luo, Xiang-Ting Wang, Sheng-Xiong Huang*. α-Pyrone derivatives from a Streptomyces strain resensitize tamoxifen resistance in breast cancer cells. Nat. Prod. Bioprospect. 2017, 7, 329-334. DOI: 10.1007/s13659-017-0136-8\r
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Yijun Yan, Jing Yang, Zhiyin Yu, Mingming Yu, Ya-Tuan Ma, Li Wang, Can Su, Jianying Luo, Geoffrey P. Horsman, Sheng-Xiong Huang*. Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids. Nat. Commun. 2016, 7, 13083. DOI: 10.1038/ncomms13083\r
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Yijun Yan, Ya-Tuan Ma, Jing Yang, Geoff P. Horsman, Dan Luo, Xu Ji, Sheng-Xiong Huang*. Tropolone ring construction in the biosynthesis of rubrolone B, a cationic tropolone alkaloid from endophytic Streptomyces. Org. Lett. 2016, 18, 1254-1257. DOI: 10.1021/acs.orglett.6b00074\r
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Zhiyin Yu, Li Wang, Jing Yang, Fan Zhang, Yun Sun, Mingming Yu, Yijun Yan, Ya-Tuan Ma*, Sheng-Xiong Huang*. A new antifungal macrolide from Streptomyces sp. KIB-H869 and structure revision of halichomycin. Tetrahedron Lett. 2016, 57, 1375-1378. DOI: 10.1016/j.tetlet.2016.02.061\r
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Pei Cao, Jing Yang, Cui-Ping Miao, Yijun Yan, Ya-Tuan Ma, Xiao-Nian Li, Li-Xing Zhao*, Sheng-Xiong Huang*. New duclauxamide from Penicillium manginii YIM PH30375 and structure revision of the duclauxin family. Org. Lett. 2015, 17, 1146-1149. DOI: 10.1021/acs.orglett.5b00081\r
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Li Wang, Ya-Tuan Ma, Qian-Yun Sun, Xiao-Nian Li, Yijun Yan, Jing Yang, Fu-Mei Yang, Feng-Yi Liu, Zhen Zang, Xiang-Hua Wu, Sheng-Xiong Huang*, Yong Zhao*. Structurally diversified diterpenoids from Euphorbia dracunculoides. Tetrahedron 2015, 71, 5484-5493. DOI: 10.1016/j.tet.2015.06.078\r
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Li Wang, Pei Cao, Zhen Zang, Ya-Tuan Ma, Feng-Yi Liu, Fei Li, Xiang-Hua Wu, Sheng-Xiong Huang*, Yong Zhao*. Two new triterpene rhamnosides from Euphorbia dracunculoides Lam. Phytochem. Lett. 2015, 12, 168-172. DOI: 10.1016/j.phytol.2015.03.015\r
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Sheng-Xiong Huang, Bong-Sik Yun, Ming Ma, Hirak S. Basu, Dawn R. Church, Gudrun Ingenhorst, Yong Huang, Dong Yang, Jeremy R. Lohman, Gong-Li Tang, Jianhua Ju, Tao Liu, George Wilding, Ben Shen*. Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proc. Natl. Acad. Sci. USA 2015, 112, 8278-8283. DOI: 10.1073/pnas.1506761112\r
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Sheng-Xiong Huang, Jeremy R. Lohman, Tingting Huang, Ben Shen*. A new member of the 4-methylideneimidazole-5-one–containing aminomutase family from the enediyne kedarcidin biosynthetic pathway. Proc. Natl. Acad. Sci. USA 2013, 110, 8069-8074. DOI: 10.1073/pnas.1304733110\r
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Sheng-Xiong Huang, Zhiyang Feng, Liyan Wang, Ute Galm, Evelyn Wendt-Pienkowski, Dong Yang, Meifeng Tao, Jane M Coughlin, Yanwen Duan*, and Ben Shen*. A designer bleomycin with significantly improved DNA cleavage activity. J. Am. Chem. Soc. 2012, 134, 13501-13509. DOI: 10.1021/ja3056535\r
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Sheng-Xiong Huang, Xiang-Jing Wang, Yijun Yan, Ji-Dong Wang, Ji Zhang, Chong-Xi Liu, Wen-Sheng Xiang*, Ben Shen*. Neaumycin: A new macrolide from Streptomyces sp. NEAU-x211. Org. Lett. 2012, 14, 1254-1257. DOI: 10.1021/ol300074d\r
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Sheng-Xiong Huang, Emily Powell, Scott R. Rajski, Li-Xing Zhao, Cheng-Lin Jiang, Yanwen Duan, Wei Xu, Ben Shen*. Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from Actinopolymorpha rutilus. Org. Lett. 2010, 12, 3525-3527. DOI: 10.1021/ol1013526\r
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Sheng-Xiong Huang, Li-Xing Zhao, Shu-Kun Tang, Cheng-Lin Jiang, Yanwen Duan, Ben Shen*. Erythronolides H and I, new erythromycin congeners from a new halophilic Actinomycete Actinopolyspora sp. YIM90600. Org. Lett. 2009, 11, 1353-1356. DOI: 10.1021/ol900143j