个人简历

工作经历\r
2017.1-pres. 中国科学院化学研究所 研究员 中科院活体分析化学重点实验室\r
2009 - 2017 中国科学院高能物理研究所 研究员 中国科学院纳米生物效应与安全性重点实验室\r
2005 - 2008 英国牛津大学 化学生物学博士后 纳米孔传感技术；纳米孔DNA测序\r
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教育背景\r
2002 - 2005 英国剑桥大学 有机化学专业博士 有机不对称催化机理研究；有机膦配体的合成\r
1998 - 2001 北京大学 有机化学专业硕士 (S)-高苯丙氨酸的合成；铜催化的不对称反应研究\r
1994 - 1998 北京大学 有机化学专业学士

研究领域

"""""1. 纳米孔技术用于生物化学中的单分子检测研究\r
2. 基于碳管纳米孔的高分辨传感器的构建\r
3. 人工离子通道的构建和应用研究"

近期论文

Liu, L.; Wu, H.-C.*, DNA-Based Nanopore Sensing. Angew. Chem. Int. Ed., 2016, 55, 15216-15222.\r
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Guo, B.; Yao, Z.; Liu, L.; Wu, H.-C.*, Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor. Chem. Sci., 2016, 7, 5287-5293.\r
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Yao, Z.*; Qiao, Y.; Liang, H.; Ge, W.; Zhang, L.; Cao, Z.; Wu, H.-C.*, Approach Based on Polyelectrolyte-Induced Nanoassemblies for Enhancing Sensitivity of Pyrenyl Probes. Anal. Chem., 2016, 88, 10605-10610.\r
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Liu, L.*; Li, Y.; Li, T.; Xie, J.; Chen, C.; Liu, Q.; Zhang, S.; Wu, H.-C.*, Selective Detection of 8-Oxo-2'-deoxyguanosine in Single-Stranded DNA via Nanopore Sensing Approach. Anal. Chem., 2016, 88, 1073-1077.\r
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Cheng, H.-B.; Hu, G.-F.; Zhang, Z.-H.; Gao, L.; Gao, X.; Wu, H.-C.*, Photocontrolled Reversible Luminescent Lanthanide Molecular Switch Based on a Diarylethene-Europium Dyad. Inorg. Chem., 2016, 55, 7962-7968.\r
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Liu, L.; Xie, J.; Li, T.; Wu, H.-C.*, Fabrication of nanopores with ultrashort single-walled carbon nanotubes inserted in a lipid bilayer, Nat. Protocols, 2015, 10, 1670-1678.\r
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Zeng, T; Liu, L.; Li, T.; Li, Y.; Gao, J.; Zhao, Y.;* Wu, H.-C.*, Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in DNA via Host-Guest Interactions inside α-Hemolysin Nanopore, Chem. Sci., 2015, 6, 5628-5634.\r
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Li, T.; Liu, L.; Li, Y.; Xie, J.; Wu, H.-C.*, A Universal Strategy for Aptamer-Based Nanopore Sensing through Host-Guest Interactions inside α-Hemolysin, Angew. Chem. Int. Ed., 2015, 54, 7568-7571.\r
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Lu, W.; Gao, J.; Yang, J.-K.*; Liu, L.; Zhao, Y.; Wu, H.-C.*, Regioselective alkyl transfer from phosphonium ylides to functionalized polyfluoroarenes. Chem. Sci. 2014, 5, 1934-1939.\r
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Zeng, T.; Li, T.; Li, Y.; Liu, L.; Wang, X.; Liu, Q.*; Zhao, Y.; Wu, H.-C.*, DNA-based detection of mercury(II) ions through characteristic current signals in nanopores with high sensitivity and selectivity. Nanoscale, 2014, 6, 8579-8584.\r
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Liu, L.; Yang, C.; Zhao, K.; Li, J.; Wu, H.-C.*, Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor. Nat. Commun. 2013, 4:2989.\r
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Yang, C.; Liu, L.; Zeng, T.; Yang, D.; Yao, Z.; Zhao, Y.; Wu, H.-C.*, Highly Sensitive Simultaneous Detection of Lead(II) and Barium(II) with G-Quadruplex DNA in alpha-Hemolysin Nanopore. Anal. Chem. 2013, 85, 7302-7307.\r
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Yao, Z.; Yang, Y.; Chen, X.; Hu, X.; Zhang, L.; Liu, L.; Zhao, Y.; Wu, H.-C.*, Visual Detection of Copper(II) Ions Based on an Anionic Polythiophene Derivative Using Click Chemistry. Anal. Chem. 2013, 85, 5650-5653.\r
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Yao, Z.; Hu, X.; Huang, B.; Zhang, L.; Liu, L.; Zhao, Y.; Wu, H.-C.*, Halochromism of a Polythiophene Derivative Induced by Conformational Changes and Its Sensing Application of Carbon Dioxide. ACS Applied Mater. & Interfaces 2013, 5, 5783-5787.\r
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Yao, Z.; Hu. X.; Ma, W.; Chen, X.; Zhang, L.; Yu, J.; Zhao, Y.; Wu, H.-C.*, Colorimetric and fluorescent dual detection of paraquat and diquat based on an anionic polythiophene derivative. Analyst, 2013, 138, 5572-5575.\r
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Yao, Z.; Huang, B.; Hu, X.; Zhang, L.; Li, D.; Guo, M.; Zhang, X.; Yuan, H.; Wu, H.-C.*, Colorimetric detection of copper ions based on a supramolecular complex of water-soluble polythiophene and ATP. Analyst, 2013, 138, 1649-1652.\r
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Zeng, T.; Hu, Y.; Wang, N.; Xia, C.; Li, S.; Zu, Y.; Liu, L.; Yao, Z.; Zhao, Y.; Wu, H.-C.*, Effects of different metal ions on the fluorescence of CdSe/ZnS quantum dots capped with various thiolate ligands. Phys. Chem. Chem. Phys., 2013, 15, 18710-18715.\r
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Wu, H.-C., Li, Y.-S.; Liu, Y.-C.; Lyu, S.-Y.; Wu, C.-J.; Li, T.-L., Chain Elongation and Cyclization in Type III PKS DpgA. ChemBioChem, 2012, 13, 862-871.\r
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Wen, S.; Zeng, T.; Liu, L.; Zhao, K.; Zhao, Y.*; Liu, X.; Wu, H.-C.*, Highly Sensitive and Selective DNA-Based Detection of Mercury(II) with alpha-Hemolysin Nanopore. J. Am. Chem. Soc. 2011, 133, 18312-18317.\r
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Liu, L.; Wu, H.-C.*; Yu, J.-Q., Improved Syntheses of Phosphine Ligands by Direct Coupling of Diarylbromophosphine with Organometallic Reagents. Chem. Eur. J. 2011, 17, 10828-10831.