个人简历
1988-1992中国药科大学药物分析专业，获学士学位。1992-1995同济医科大学附属协和医院临床药学实验室工作，主要从事治疗药物监测以及中药制剂临床前研究。1995-1998中国协和医科大学，中国医学科学院医药生物技术研究所，获硕士学位，主要从事新抗生素筛选，天然产物分离分析研究。1998-2001中国科学院化学研究所，获博士学位，主要从事生物活性物质的高灵敏度检测研究。2001-2003中国科学院化学研究所生命分析化学实验室，助理研究员，主要从事生物活性物质的动态生化分析、生物色谱研究。2003-2006佛罗里达大学化学系，肿瘤研究中心，博士后，主要从事肿瘤细胞核酸适体（aptamer）的筛选和应用研究。2007-至今中国科学院化学研究所活体分析化学实验室，研究员。2002年度,2013年度中国分析测试协会科学技术奖（CAIA奖）一等奖
研究领域
""研究方向1）新型识别分子的筛选、设计与构筑2）分子探针的构建与应用3）亲和分离材料的制备与应用"""复杂体系的分离分析\r生化分析：分子探针\r分子间相互作用研究"
近期论文
论文著20161.YingLiu#,JinZhou#,LinlinWang#,XiaoxiaoHu,XiangjunLiu,MeirongLiu,ZehuiCao,DihuaShangguan*,andWeihongTan.ACyanineDyetoProbeMitophagy:SimultaneousDetectionofMitochondriaandAutolysosomesinLiveCells,J.Am.Chem.Soc.,2016,138(38),12368–12374.2.NanZhang,TaoBing,LuyaoShen,RushengSong,LinlinWang,XiangjunLiu,MeirongLiu,JuanLi,WeihongTan*andDihuaShangguan*IntercellularConnectionsRelatedtoCell–CellCrosstalkSpecificallyRecognizedbyanAptamer.Angew.Chem.Int.Ed.2016,55,3914–3918.3.XinZhang,BingJin,WeiZheng,NanZhang,XiangjunLiu,TaoBing,YongbiaoWei,FuyiWang,DihuaShangguan*,Interactionofhypericinwithguanine-richDNA:PreferentialbindingtoparallelG-Quadruplexes,DyesandPigments132(2016)405-411.4.ShangrongWu,LinlinWang,NanZhang,YingLiu,WeiZheng,AngChang,FuyiWang,SongqinLiandDihuaShangguan*,ABis-methylpiperazin-styrylPhenanthrolineasaFluorescentLigandforG-Quadruplexes,Chem.Eur.J.2016,22,6037–6047.5.TianjunChang,HongmeiGong,PiDing,XiangjunLiu,WeiguoLi,TaoBing,ZehuiCao,andDihuaShangguan*ActivityEnhancementofG-Quadruplex/HeminDNAzymebyFlankingd(CCC),Chem.Eur.J.2016,22,4015–4021.6.常昂，吴尚荣，柳影，张鑫，魏涌标，李松青*，刘祥军*,上官棣华。基于新铜试剂的铜离子荧光探针的设计合成及性能研究,分析科学学报，32卷01期，pp58-62，2016/2.20157.XiangjunLiu*,LinlinWang,NanZhangandDihuaShangguan*,Ratiometricfluorescentsilvernanoclustersforthedeterminationofmercuryandcopperions,Anal.Methods,2015,7(19),8019-8024.8.NanZhang,TaoBing,XiangjunLiu,CuiQi,LuyaoShen,LinlinWangandDihuaShangguan*,Cytotoxicityofguanine-baseddegradationproductscontributestotheantiproliferativeactivityofguanine-richoligonucleotides,Chem.Sci.,2015,6(7),3831-3838.9.JinZhou,CanliangFang,YingLiu,YaoZhao,NanZhang,XiangjunLiu,FuyiWangandDihuaShangguan*,Visible-light-inducedcleavageof4-alpha-aminoacidsubstitutednaphthalimidesanditsapplicationinDNAphotocleavage,Organic&BiomolecularChemistry,2015,13(13)3931-3935.10.YingLiu,LinlinWang,JinZhou,ShangrongWu,YongbiaoWei,AngChang,XiangjunLiu,DihuaShangguan*,DNAinteractionandcellularlocalizationofquinacridonederivatives,DyesandPigments,2015,121,328–335.11.YongbiaoWei,XinZhang,LinlinWang,YingLiu,TaoBing,XiangjunLiuandDihuaShangguan*,Interactionofbisbenzimidazole-substitutedcarbazolederivativeswithG-quadruplexesandlivingcells,RSCAdv.,2015,5（93）,75911-75917.12.TaoBing,DihuaShangguan*andYinshengWang*,FacileDiscoveryofCell-SurfaceProteinTargetsofCancerCellAptamers,Molecular&CellularProteomics,2015,14,2692-2700.13.常昂,刘祥军,吴尚荣,柳影,王林林,张楠,李松青*,上官棣华*.化学通报,2015,78(12)1101.201414.CuiQi,NanZhang,JingliYan,XiangjunLiu,TaoBing,HongchengMei,andDihuaShangguan*,ActivityenhancementofG-quadruplex/heminDNAzymebyspermine,RSCAdv.,2014,4(3),1441-1448.15.BingJin,XinZhang,WeiZheng,XiangjunLiu,CuiQi,FuyiWang,andDihuaShangguan*,FluorescenceLight-UpProbeforParallelG-Quadruplexes,Anal.Chem.,2014,86(1),943-952.16.XiangjunLiu,NanZhang,TaoBing,andDihuaShangguan*,CarbonDotsBasedDual-EmissionSilicaNanoparticlesasaRatiometricNanosensorforCu2+,Anal.Chem.,2014,86(5),2289-2296.17.TaoBing#,HongchengMei#,NanZhang,CuiQi,XiangjunLiu,andDihuaShangguan*,ExacttailoringofanATPcontrolledstreptavidinbindingaptamer,RSCAdv.,2014,4(29),15111-15114.18.BingJin,XinZhang,WeiZheng,XiangjunLiu,JinZhou,NanZhang,FuyiWang,DihuaShangguan*,Dicyanomethylene-FunctionalizedSquaraineasaHighlySelectiveProbeforParallelG-Quadruplexes,Anal.Chem.,2014,86(14),7063-7070.19.JinZhou,AngChang,LinlinWang,YingLiu,XiangjunLiuandDihuaShangguan*,EffectsofsidechainsonDNAbinding,cellpermeability,nuclearlocalizationandcytotoxicityof4-aminonaphthalimides,Org.Biomol.Chem.,2014,12(45),9207-9215.20.吴尚荣,金冰,张楠,柳影,刘祥军,李松青*,上官棣华*,一种不对称菁染料及其与不同结构DNA的相互作用,高等学校化学学报,2014,35(10),2085-2092.21.YuanyuanWang#,YunLuo#,TaoBing,ZhengChen,MinhuaLu,NanZhang,DihuaShangguan*,XinGao*,DNAAptamerEvolvedbyCell-SELEXforRecognitionofProstateCancer,PLoSONE,2014,9(6),e100243.22.Wan-MingLi,TaoBing,Jia-YiWei,Zhe-ZhouChen,Di-HuaShangguan*,JinFang*,Cell-SELEX-basedselectionofaptamersthatrecognizedistincttargetsonmetastaticcolorectalcancercells,Biomaterials,2014,35(25),6998-7007.23.常天俊,李刚,赵可旭,班琳,卞文秀,邴涛,上官棣华*,连接环、末端碱基及一价阳离子对G-四链体结构的影响(EffectsofLoops,FlankingBasesandMonovalentCationsontheStructuresofG-Quadruplexes),高等学校化学学报,2014,Vol.35,Issue(12):2556-2562.2013:24.JinZhou,HuiyingLiu,BinJing,XiangjunLiu,HongbingFu,andDihuaShangguan*,Aguanidinederivativeofnaphthalimidewithexcited-statedeprotonationcoupledintramolecularchargetransferpropertiesanditsapplication,J.Mater.Chem.C,2013,1,4427-4436.25.TianjunChang,CuiQi,JieMeng,NanZhang,TaoBing,XiandaYang,ZehuiCao,DihuaShangguan*,GeneralCell-BindingActivityofIntramolecularG-QuadruplexeswithParallelStructure,PlosOne,2013,8,e62348.26.JingliYan,NanZhang,CuiQi,XiangjunLiu,DihuaShangguan*,One-steprealtimeRT-PCRfordetectionofmicroRNAs,Talanta,2013,110,190-195.27.JinZhou,CanliangFang,TianjunChang,XiangjunLiu,DihuaShangguan*,ApHsensitiveratiometricfluorophoreanditsapplicationforcellularpHmeasurement,J.Mater.Chem.B,2013,1(5),661–667.28.HongchengMei,TaoBing,CuiQi,NanZhang,XiangjunLiu,TianjunChang,JingliYan,DihuaShangguan*,RationaldesignofHg2+controlledstreptavidin-bindingaptamer,Chem.Commun.,2013,49,164-166.29.CuiQi,TaoBing,HongchengMei,XiaojuanYang,XiangjunLiu,DihuaShangguan*,G-quadruplexDNAaptamersforzeatinrecognizing,Biosens.Bioelectron.,2013,41,157-162.30.XiangjunLiu,NanZhang,JinZhou,TianjunChang,CanliangFang,andDihuaShangguan*,Aturn-onfluorescentsensorforzincandcadmiumionbasedonperylenetetracarboxylicdiimide,Analyst,2013,138,901-906.31.LiangliangHuang,XiaojuanYang,CuiQi,XiaofangNiu,ChunlingZhao,XiaohuiZhao,DihuaShangguan*,YunhuiYang*,Alabel-freeelectrochemicalbiosensorbasedonaDNAaptameragainstcodeine,AnalyticaChimicaActa787(2013)203–210.32.程晓宏;谢超;史玉坤;上官棣华,一种快速测定铅离子的新方法,Anewrapidmethodforleaddetection卷:32期:7,页:118-120,2013,ChineseJournalofAnalysisLaboratory分析试验室.2012：33.HongchengMei,TaoBing,XiaojuanYang,CuiQi,TianjunChang,XiangjunLiu,ZehuiCao,DihuaShangguan*,Functional-GroupSpecificAptamersIndirectlyRecognizingCompoundswithAlkylAminoGroup,Anal.Chem.,2012,84,7323-7329.34.TianjunChang,XiangjunLiu,XiaohongCheng,CuiQi,HongchengMei,DihuaShangguan*,SelectiveisolationofG-quadruplexesbyaffinitychromatography,J.Chromatogr.A,2012,1246,62-68.35.TaoBing,TianjunChang,CuiQi,NanZhang,XiangjunLiu,DihuaShangguan*,Specificinteractionsbetweenadenosineandstreptavidin/avidin,Bioorg.Med.Chem.Lett.,2012,22,7052-7055.2011:36.Can-liangFang,JinZhou,Xiang-junLiu,Ze-huiCao,andDi-huaShangguan*,Mercury(II)-mediatedformationofimide-Hg-imidecomplexes,DaltonTrans.,2011,40,899-903.37.XiaojuanYang,TaoBing,HongchengMei,CanliangFang,ZehuiCaoandDihuaShangguan*,CharacterizationandapplicationofaDNAaptamerbindingtoL-tryptophan,Analyst,2011,136,577–585.38.TaoBing,TianjunChang,XiaojuanYang,HongchengMei,XiangjunLiuandDihuaShangguan*,G-quadruplexDNAAptamersGeneratedforSystemin,Bioorg.Med.Chem.,2011,19,4211-4219.39.XiaojuanYang,CanliangFang,HongchengMei,TianjunChang,ZehuiCao,andDihuaShangguan*,CharacterizationofG-Quadruplex/HeminPeroxidase:SubstrateSpecificityandInactivationKinetics,Chem.Eur.J.,2011,17,14475-14484.2010:40.TaoBing,XiangjunLiu,XiaohongCheng,ZehuiCao,DihuaShangguan*,Bifunctionalcombinedaptamerforsimultaneousseparationanddetectionofthrombin,Biosens.Bioelectron.,2010,25,1487-1492.41.TaoBing,XiaojuanYang,HongchengMei,ZehuiCao,DihuaShangguan*,Conservativesecondarystructuremotifofstreptavidin-bindingaptamersgeneratedbydifferentlaboratories,Bioorg.Med.Chem.,2010,18,1798-1805.42.XiangjunLiu,XiaohongCheng,TaoBing,CanliangFang,andDihuaShangguan*,VisualDetectionofHg2+withHighSelectivityUsingThymineModifiedGoldNanoparticles,Anal.Sci.,2010,26,1169-1172.43.KwameSefah,DihuaShangguan,XianglingXiong,MeghanBO'Donoghue&WeihongTan,DevelopmentofDNAaptamersusingCell-SELEX,NatureProtocols,2010,5,1169-1185.2009:44.XiangjunLiu,CuiQi,TaoBing,XiaohongCheng,andDihuaShangguan*,Specificmercury(II)adsorptionbythyminebasedsorbent,Talanta,2009,78,253–258.45.XiaohongCheng,TaoBing,XiangjunLiu,andDihuaShangguan*,Alabel-freefluorescencesensorforprobingtheinteractionofoligonucleotideswithtargetmolecules,Anal.Chim.Acta,2009,633,97–102.46.XiangjunLiu,CuiQi,TaoBing,XiaohongCheng,andDihuaShangguan*,HighlySelectivePhthalocyanine-ThymineConjugateSensorforHg2+BasedonTargetInducedAggregation,Anal.Chem.,2009,81,3699-3704.47.XiaohongCheng,XiangjunLiu,TaoBing,ZehuiCao,andDihuaShangguan*,GeneralPeroxidaseActivityofG-Quadruplex-HeminComplexesandItsApplicationinLigandScreening,Biochemistry,2009,48,7817–7823.48.XiaohongCheng,XiangjunLiu,TaoBing,RuiZhao,ShaoxiangXiong,andDihuaShangguan*,SpecificDNAG-QuadruplexesBindtoEthanolamines,Biopolymers2009,91,874-883.49.XiangjunLiu,JizhongLiu,YanyanHuang,RuiZhao*,GuoquanLiu,YiChen,Determinationofmethotrexateinhumanserumbyhigh-performanceliquidchromatographycombinedwithpseudotemplatemolecularlyimprintedpolymer,J.Chromatogr.A,2009,216,7533-7538.Before50.D.Shangguan,Z.Cao,L.Meng,P.Mallikaratchy,K.Sefah,H.Wang,Y.LiandW.Tan,Cell-specificAptamerProbesforMembraneProteinElucidationinCancerCells.J.ProteomeRes.,2008,7(5),2133-2139.51.D.Shangguan,L.Meng,Z.C.Cao,Z.Xiao,X.Fang,Y.Li,D.Cardona,R.P.Witek,C.Liu,andW.Tan,IdentificationofLiverCancer-specificAptamersUsingWholeLiveCells.Anal.Chem.,2008,80(3),721-728.52.D.Shangguan,Z.Tang,P.Mallikaratchy,Z.XiaoandW.Tan,OptimizationandModificationsofAptamersSelectedfromLiveCancerCellLines.Chembiochem,2007,8(6),603-606.53.D.Shangguan,C.Cao,Y.LiandW.Tan,AptamersEvolvedfromCancerCellsRevealMolecularDifferencesofCancerPatientSamples.ClinChem,2007,53(6),1153-1155.54.X.Liu,ZChen,RZhao,DShangguan,GLiu,YChen,.Uniform-sizedMolecularlyImprintedPolymerforMetsulfuron-MethylbyOne-stepSwellingandPolymerizationMethod.Talanta,2007,71,1205-1210.55.刘祥军、刘吉众、赵睿*、刘国诠、陈义，三甲氧苄啶分子印迹整体柱的制备及色谱性能，高等学校化学学报，2007，28，1878-1880.56.D.Shangguan,Y.Li,Z.Tang,Z.C.Cao,H.W.Chen,P.Mallikaratchy,K.Sefah,C.J.YangandW.Tan,.AptamersEvolvedfromLiveCellsasEffectiveMolecularProbesforCancerStudy.Proc.Natl.Acad.Sci.USA,2006,103,11838-11843.57.X.Liu,C.Ouyang,R.Zhao,D.Shangguan,Y.Chen,G.Liu,MonolithicMolecularlyImprintedPolymerforSulfamethoxazoleandMolecularRecognitionPropertiesinAqueousMobilePhase.Anal.Chim.Acta,2006,571,235-241.
