个人简历
招生方向生物力学生物医学工程教育背景 1989-03--1990-03 日本群马大学 中日联合培养博士1984-09--1990-07 重庆大学 博士1980-09--1984-07 上海交通大学 学士工作简历2000-07~现在, 中国科学院力学研究所, 研究员1996-06~1999-08,美国佐治亚理工学院, 高级访问学者1995-03~2000-07,重庆大学生物工程学院, 教授1992-04~1995-03,重庆大学生物工程学院, 副研究员1990-07~1992-04,重庆大学生物工程学院, 讲师教授课程 生物力学博士生综合基础课（生物力学）现代生物物理前沿系列讲座生物力学进展荣誉及获奖情况 2000年入选中科院****2002年获国家杰出青年基金2004年入选新世纪百千万人才工程国家级人选 发表著作1.朱承，龙勉 主编．2001．《生物力学的最新进展》．高等教育出版社/施普林格出版社．2.龙勉，季葆华主编．2018．《细胞分子生物力学》．上海交通大学出版社．科研活动 研究兴趣为蛋白质间相互作用的力学与动力学、细胞-亚细胞的力学-生物学耦合、空间细胞-分子生物力学工程。先后主持科技部973项目、国家自然科学基金重点项目、重大仪器研制项目、重大国际合作项目、中国科学院创新工程方向性项目、国家载人航天工程空间实验项目等项目。
研究领域
"生物力学生物医学工程"
近期论文
（1） Microgravity-induced hepatogenic differentiation of rBMSCs on board the SJ-10 satellite, FASEB Journal, 2019, 通讯作者（2） Impact of real-time shedding on binding kinetics of membrane-remaining L-selectin to PSGL-1, American Journal of Physiology-Cell Physiology, 2019, 通讯作者（3） Microgravity-induced alterations of inflammation-related mechanotransduction in endothelial cells on board SJ-10 satellite, Frontiers in Physiology, 2018, 通讯作者（4） Mechanical strength and structural basis of β2 integrin to mediate neutrophil accumulation on liver sinusoidal endothelial cells: A study using atomic force microscopy and molecular dynamics simulations, CMES-Computer Modeling in Engineering & Sciences, 2018, 通讯作者（5） Computational model of wound healing: EGF secreted by fibroblasts promotes delayed re-epithelialization of epithelial keratinocytes, Integrative Biology, 2018, 第 9 作者（6） Binding of intercellular adhesion molecule 1 to β2-integrin regulates distinct cell adhesion processes on hepatic and cerebral endothelium, American Journal of Physiology-Cell Physiology, 2018, 通讯作者（7） Theoretical modeling of mechanical homeostasis of a mammalian cell under gravity-directed vector, Biomechanics and Modeling in Mechanobiology, 2018, 通讯作者（8） Ligand-specific binding forces of LFA-1 and Mac-1 in neutrophil adhesion and crawling, Molecular Biology of the Cell, 2018, 通讯作者（9） Conformational folding and disulfide bonding drive distinct stages of protein structure formation, Scientific Reports, 2018, 通讯作者（10） Salt bridge interactions within the β2 integrin α7 helix mediate force-induced binding and shear resistance ability, The FEBS Journal, 2018, 通讯作者（11） Mechanical remodeling of normally sized mammalian cells under gravity vector, FASEB Journal, 2017, 通讯作者（12） Dynamic contributions of P- and E-selectin to beta-2 integrin induced neutrophil transmigration, FASEB journal, 2017, 通讯作者（13） Neutrophil adhesion and crawling dynamics on liver sinusoidal endothelial cells under shear flow, Experimental Cell Research, 2017, 通讯作者（14） Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip, Lab on a Chip, 2017, 通讯作者（15） Flow dynamics analyses of pathophysiological liver lobules upon porous media theory, Acta Mechanica Sinica, 2017, 通讯作者（16） Mechanical regulation of organ asymmetry in leaves, Nature Plants, 2017, 通讯作者（17） Improving the gene transfection in human embryonic stem cells: Balancing with cytotoxicity and pluripotent maintenance, ACS Applied Materials and Interfaces, 2016, 通讯作者（18） Structural basis for differences in dynamics induced by Leu versus Ile residues in the CD loop of Kir channels, Molecular Neurobiology, 2015, 通讯作者（19） Contribution of the CR domain to P-selectin lectin domain allostery by regulating the orientation of the EGF domain, PLoS One, 2015, 通讯作者（20） Mechanomics: An emerging field between biology and biomechanics, Protein & Cell, 2014, 通讯作者（21） Differential regulation of substrate stiffness and topography on morphology and stemness of mouse embryonic stem cells, Biomaterials, 2014, 通讯作者（22） Asymmetric migration of human keratinocytes under mechanical stretch and cocultured fibroblasts in a wound repairing model, PLoS One, 2013, 通讯作者（23） Differential Regulation of Stiffness, Topography, and Dimension of Substrate on Rat Mesenchymal Stem Cells, Biomaterials, 2013, 通讯作者（24） Distinct binding affinities of Mac-1 and LFA-1 in neutrophil activation, The Journal of Immunology, 2013, 通讯作者（25） The cytosolic GH-loop regulates the PIP2-induced gating kinetics of Kir2 channels, Journal of Biological Chemistry, 2012, 通讯作者（26） Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-Selectin on the cell membrane, Biophysical Journal, 2012, 通讯作者（27） Multi-patterned dynamics of mitochondrial fission and fusion in a living cell, PLoS One, 2012, 通讯作者（28） Shear- and stretch-induced dissociation of P-selectin/PSGL-1 complex using molecular dynamics simulation, Biophysical Journal, 2012, 通讯作者（29）Determining beta(2)-integrin and intercellular adhesion molecule 1 binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay. Journal of Biological Chemistry, 2011, 通讯作者（30）Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1. PLoS One, 2011, 通讯作者（31）Identification of a residue in helix 2 of rice plasma membrane intrinsic proteins that influences water permeability. Journal of Biological Chemistry, 2010, 通讯作者（32）Visualization of allostery in P-selectin lectin domain using MD simulations. PLoS One, 2010, 通讯作者（33）Low spring constant regulates P-selectin-PSGL-1 bond rupture. Biophysical Journal, 2008, 通讯作者（34）Impact of carrier stiffness and microtopology on two-dimensional kinetics of P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) interactions. Journal of Biological Chemistry, 2007, 通讯作者（35）Probabilistic modeling of rosette formation. Biophysical Journal, 2006, 通讯作者（36）Quantifying the effects of contact duration, loading rate, and approach velocity on P-selectin-PSGL-1 interactions using AFM. Polymer, 2006, 通讯作者（37）Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics. Journal of Biological Chemistry, 2004, 通讯作者（38）Direct observation of catch bonds involving cell-adhesion molecules. Nature, 2003, 第2作者（39）Probabilistic modeling of shear-induced formation and breakage of doublets cross-linked by receptor-ligand bonds. Biophysical Journal, 1999, 第1作者历任世界生物力学理事会执委、国际生物流变学会理事，中国力学学会副理事长、中国力学学会/中国生物医学工程学会生物力学专业委员会主任、中国生物物理学会生物力学与生物流变学专业委员会主任，以及Cell. Mol. Bioengi.、Biomed. Online、Biophys. Rep.副主编、Mol. Cell. Biomech.和J. Biorhol.编委。
