个人简历

招生专业
071008-发育生物学
071007-遗传学
071021-生物信息学

教育背景
2009-06--2015-01 Memorial Sloan Kettering Cancer Center 博士后
2008-09--2009-06 Albert Einstein College of Medicine 博士后
2003-09--2008-06 中国农业大学 博士
教授课程
高级分子遗传学
文献阅读

研究领域

发育功能基因组学，细胞命运决定调控机制，发育基因表达调控"动物胚胎发育的多维度调控"

近期论文

Multivariable regulation of gene expression plasticity in metazoans.
Xiao L#, Zhao Z#, He F*, Du Z*.
Open Biol. 2019 Dec;9(12):190150.
Lineage context switches the function of a C. elegans Pax6 homolog in determining a neuronal fate.
Brandt JP, Rossillo M, Du Z, Ichikawa D, Barnes K, Chen A, Noyes M, Bao Z, Ringstad N*.
Development. 2019 Apr 15;146(8).
Systems Properties and Spatiotemporal Regulation of Cell Position Variability during Embryogenesis.
Li X#, Zhao Z#, Xu W, Fan R, Xiao L, Ma X, Du Z*.
Cell Rep. 2019 Jan 8;26(2):313-321.e7.
mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation.
Zhang G, Wang Z, Du Z, Zhang H*.
Cell. 2018 Sep 6;174(6):1492-1506
Trans-splicing enhances translational efficiency in C. elegans.
Yang YF, Zhang X, Ma X, Zhao T, Sun Q, Huan Q, Wu S, Du Z*, Qian W*.
Genome Res. 2017 Sep;27(9):1525-1535.

Digital Development: A database of C. elegans cell lineage differentiation with lineage phenotypes, cell-specific gene functions and a multiscale model.
Santella A, Kovacevic I, Herndon L Hall D, Du Z*, Bao Z*.
Nucleic Acids Res. 2016 Jan 4;44(D1):D781-5.

The Regulatory Landscape of lineage differentiation in a metazoan embryo.
Du Z*, Santella A, He F, Shah PK, Kamikawa Y, Bao Z*.
Dev. Cell. 2015 2015 Sep 14;34(5):592-607. (Free Featured Article)

POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H, Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC*
Dev. Cell. 2015 Jul 6;34(1):108-18. Recommend by F1000

E3 ubiquitin ligases promote progression of differentiation during C. elegans embryogenesis.
Du Z, He F, Yu Z, Bowerman B, Bao Z*.
Dev. Biol. 2015 Feb 15;398(2):267-79.

De novo inference of systems-level mechanistic models of development from live imaging-based phenotype analysis.
Du Z, Stantella A., He F., Tiongson M, Bao Z*.
Cell. 2014 Jan 16;156(1-2):359-72.

Systematic quantification of developmental phenotypes at single-cell resolution during embryogenesis.
Moore JL, Du Z, Bao Z*.
Development. 2013 Aug;140(15):3266-74.

Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans.
Wu Y*, Ghitani A, Christensen R, Santella A, Du Z, Rondeau G, Bao Z, Colón-Ramos D, Shroff H.
Proc. Natl. Acad. Sci. U S A. 2011 Oct 25;108(43):17708-13. Recommend by F1000
Single-molecule analysis reveals changes in the DNA replication program for the POU5F1 locus upon human embryonic stem cell differentiation.
Schultz SS, Desbordes SC, Du Z, Kosiyatrakul S, Lipchina I, Studer L, Schildkraut CL*.
Mol. Cell. Biol. 2010 Sep;30(18):4521-34.

Genome-wide colonization of gene regulatory elements by G4 DNA motifs.
Du Z, Zhao Y, Li N*.
Nucleic Acids Res. 2009 Nov;37(20):6784-98.

Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription.
Du Z, Zhao Y, Li N*.
Genome Res. 2008 Feb;18(2):233-41. (Highlighted on Cover)