个人简历

招生方向
重大疾病精准基因组学研究
微生物宏基因组学研究
肿瘤等重大疾病相关非编码RNA研究
教育背景
2000-09--2003-12 吉林大学 博士
1997-09--2000-07 吉林大学 硕士
1992-09--1996-07 四川大学 本科
教授课程
基因组信息系统与实践
分子遗传学和表观遗传学
Molecular Genetics and Epigenetics
Omics in Diseas
基因组学前沿
组学在疾病与健康中的应用
基因组学
在研项目
1、基于Hi-C及ChIA-PET技术的结核分枝杆菌复合群（MTBC）3D、4D基因组差异研究；任务来源：国家任务-国家自然科学基金课题（面上项目）；起止时间：2018.01.01-2021.12.31；科研经费：60.0万元；本人角色：负责人。
2、DNA存储技术的研究；任务来源：国家任务-其他国家任务；起止时间：2017.09.01-2018.08.31；科研经费：300万元；本人角色：负责人。
3、青海牦牛基因组重测序及其肠道菌群测序分析；任务来源：地方任务-地方科技攻关计划课题；起止时间：2017.07.01-2020.12.31；科研经费：110万元；本人角色：负责人。
4、建立基于宏基因组的涉毒人群推断的分析体系；任务来源：中国科学院计划-院重点部署项目；起止时间：2016.01.01-2018.12.31；科研经费100万元；本人角色：参与。
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研究领域

1、重大疾病的精准基因组学的研究：包括致病微生物（结核杆菌、肺克等）精准基因组学研究、II型糖尿病肠道微生物宏基因组学研究、肿瘤等重大疾病相关非编码RNA研究等。本课题组通过大样本病患、多组学大数据的整合分析，全景式地研究上述疾病的基因组结构、变异、功能及其演化规律，系统发掘疾病相关DNA功能元件或靶向位点，并深入揭示其致病分子机制，为疾病的精准诊治提供基础，普惠社会，造福万民。
2、基于新型功能核苷酸类似物的快速灵敏的疾病诊断及法医鉴定检验试剂盒的研发""

近期论文

1. Xinmiao Jia#, Li Yang#, Mengxing Dong#, Suting Chen#, Lingna Lv#, Dandan Cao, Jing Fu, Tingting Yang, Ju Zhang, Xiangli Zhang, Yuanyuan Shang, Guirong Wang, Yongjie Sheng, Hairong Huang* and Fei Chen*. The bioinformatics analysis of comparative genomics of Mycobacterium tuberculosis complex (MTBC) provides insight into dissimilarities between intraspecific groups differing in host association, virulence and epitope diversity. Frontiers in Cellular and Infection Microbiology. 2017.
2. Lei Zhang, Jun Zhong, Hao Liu, Kaiyun Xin, Chaoqiong Chen, Qiqi Li, Yahong Wei, Yao Wang, Fei Chen*, Xihui Shen*. Complete genome sequence of the drought resistance-promoting endophyte Klebsiella sp. LTGPAF-6F. Journal of Biotechnology. 2017.
3. Fei Chen, Yuan Zhang, Ashley B. Daugherty, Zunyi Yang, Ryan Shaw, Mengxing Dong, Stefan Lutz, Steven A. Benner*. Biological phosphorylation of an unnatural base pair (UBP) using a Drosophila melanogasterdeoxynucleoside kinase (DmdNK) mutant. PLoS ONE. 2017.
4. Lingna Lv#, Cuidan Li#, Xiuli Zhang#, Nan Ding, Tianshu Cao†, Xinmiao Jia, Jinghui Wang, Liping Pan, Hongyan Jia, Zihui Li, Ju Zhang, Fei Chen* and Zongde Zhang*. RNA profiling Analysis of the Serum Exosomes Derived from Patients with Active and Latent Mycobacterium tuberculosis infection. Frontiers in Microbiology. 2017.
5. Qing Liu#, Guocheng Liu#, Ting Wang#, Jing Fu, Rujiao Li, Linlin Song, Zhen-Gang Wang*, Baoquan Ding* and Fei Chen*. Enhanced Stability of DNA Nanostructures by Incorporation of Unnatural Base Pairs. Chemphyschem. 2017.
6. Yahong Wei# , Jing Fu# , Jianying Wu# , Xinmiao Jia# , Yunheng Zhou# , Cuidan Li, Mengxing Dong, Shanshan Wang, Ju Zhang*, Fei Chen*. Bioinformatics analysis and characterization of highly efficient polyvinyl alcohol (PVA)-degrading enzymes from the novel PVA degrader Stenotrophomonas rhizophila QL-P4. Applied and Environmental Microbiology. 2017.
7. Zhu L#, Zhong J#, Jia X#, Liu G#, Kang Y#, Dong M, Zhang X, Li Q, Yue L, Li C, Fu J, Xiao J, Yan J, Zhang B, Lei M, Chen S, Lv L, Zhu B,Huang H*,Chen F*. Precision methylome characterization of Mycobacterium tuberculosis complex (MTBC) using PacBio Single-Molecule Real-Time (SMRT) Technology.Nucleic Acids Research. 2016. 44(2): 730-743.
8. Chen F,Yang Z, Yan M, Brian JA, Wang GG, Benner SA. Recognition of an expanded genetic alphabet by type-II restriction endonucleases and their application to analyze polymerase fidelity.Nucleic Acid Res. 2011. 39: 3949-61.
9. Yang Z#,Chen F#, Brian JA, Benner SA. Amplification, Mutation, and Sequencing of a Six-Letter Synthetic Genetic System.J Am Chem Soc.2011. 133: 15105-12.
10. Chen F,Gaucher EA, Leal, NA, Hutter D, Havemann SA, Govindarajan S, Ortlund EA, Benner SA. Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection.Proc. Natl. Acad. Sci.USA. 2010. 107: 1948-53.
11. Yang Z,Chen F,Chamberlin SG, Benner SA. Expanded genetic alphabets in the polymerase chain reaction. Angew. Chem. Int. Edit 2010. 49: 177-80. (“Faculty of 1000 Biology” selection).