个人简历

招生专业
0710Z2-计算生物学
086000-生物与医药
招生方向
系统基因组学，计算生物学
工作简历
2015-09~现在, University College London, Dept.of Women’s Cancer, Principal Research Associate in Statistical Cancer Genomics
2013-09~现在, 中国科学院-马普学会计算生物学伙伴研究所, 计算系统基因组学课题组PI
2008-09~现在, University College London, UCL Cancer Institute, Principal Research Associate in Statistical Cancer Genomics (2008-2013). Newton Advanced Fellow (2015–2018).
2003-09~2008-08,University of Cambridge, Department of Oncology, Senior Postdoctoral Fellow in Computational Biology
2001-08~2003-08,University of Warwick, Mathematics Institute, Research Assistant in Mathematical Ecology
2000-07~2001-07,British Telecom Labs, Complexity Research, Member of the Complexity Research Group headed by Dr Sverrir Olafsson.
科研项目
（ 1 ） 癌症系统表观基因组学新型生物信息统计算法研究, 主持, 国家级, 2016-01--2019-12
（ 2 ） 表观基因组关联分析新型细胞类型去卷积算法研究, 主持, 国家级, 2018-01--2021-12

研究领域

""

近期论文

（1） Stochastic epigenetic outliers can define field defects in cancer., BMC Bioinformatics, 2016, 第 1 作者
（2） Epigenetic drift, epigenetic clocks and cancer risk., Epigenomics, 2016, 通讯作者
（3） Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer., Epigenetics Chromatin, 2016, 通讯作者
（4） DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer., Nature Communications, 2016, 第 1 作者
（5） The integrative epigenomic-transcriptomic landscape of ER positive breast cancer., Clin Epigenetics, 2015, 通讯作者
（6） HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer., Genome Med, 2015, 第 1 作者
（7） Variational Bayesian Matrix Factorization for Bounded Support Data., IEEE Trans Pattern Anal Mach Intell., 2015, 第 2 作者
（8） An integrative pan-cancer wide analysis of epigenetic enzymes reveals universal patterns of epigenetic deregulation in cancer., Genome Biol, 2015, 通讯作者
（9） Smoking-associated DNA methylation changes in buccal cells correlate with DNA methylation changes in epithelial cancer., JAMA Oncol, 2015, 第 1 作者
（10） Increased signalling entropy in cancer requires the scale-free property of protein interaction networks., Sci Rep, 2015, 第 1 作者
（11） Denoising perturbation signatures reveals an actionable AKT signalling gene module underlying a poor clinical outcome in endocrine treated ER+ breast cancer., Genome Biol, 2015, 第 1 作者
（12） Intra-tumour molecular entropy determines clinical outcome in breast and lung cancer., PLoS Comput. Biol., 2015, 通讯作者
（13） An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging., PLoS Genetics, 2015, 通讯作者
（14） Biomedical data integration, modeling, and simulation in the era of big data and translational medicine, Biomed Res Int, 2014, 第 2 作者
（15） The dynamics of DNA methylation covariation patterns in carcinogenesis., PLoS Comput Biol., 2014, 通讯作者
（16） Comparisons of non-gaussian statistical models in DNA methylation analysis., Int J Mol Sci., 2014, 第 2 作者
（17） A systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies dif- ferential gene expression modules under epigenetic control., Bioinformatics, 2014, 通讯作者
（18） Signalling entropy: A novel network-theoretical framework for systems analysis and interpretation of functional omic data., Methods., 2014, 通讯作者
（19） Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development., PLoS Med, 2013, 第 2 作者
（20） Cellular network entropy as the energy potential in Waddington’s differentiation landscape., Sci Rep., 2013, 通讯作者
（21） Epigenetic aging: insights from network biology., Aging (Albany NY), 2013, 通讯作者
（22） The distinctive topology of age-associated epigenetic drift in the human interactome., Proc Natl Acad Sci USA., 2013, 通讯作者
（23） Age-associated epigenetic drift: implications, and a case of epigenetic thrift?., Hum Mol Genet., 2013, 通讯作者
（24） A variational Bayes Beta Mixture Model for improved clustering and feature selection in DNA methylation studies., Journal of Bioinformatics and Computational Biology, 2013, 通讯作者
（25） An integrative network algorithm identifies age-associated differential DNA methylation interactome hotspots tar- geting stem cell differentiation pathways., Sci Rep, 2013, 通讯作者
（26） Identification and functional validation of HPV-mediated hypermethylation in head & neck squamous cell carcinoma., Genome Medicine, 2013, 通讯作者
（27） A Beta-Mixture Quantile Normalisation method for correcting probe design bias in Illumina Infinium 450k DNA methylation data., Bioinformatics, 2013, 通讯作者