郑昌成
近期热点
资料介绍
个人简历
主要学习、工作、出国经历2011/09 –2014/06,山东大学,内科学(血液病),博士2005/09 –2008/06,安徽医科大学,内科学(血液病),硕士1994/09 – 1999/06,安徽医科大学,临床医学系,学士2017.12-至今,安徽省立医院血液科,主任医师2011.12 – 2017.11,安徽省立医院血液科,副主任医师,副教授2005.12 – 2011.11,安徽省立医院血液科,主治医师,讲师1999.07-2005.11,安徽省立医院血液科,住院医师、住院总医师研究领域
重点围绕造血干细胞移植、高危与难治急性白血病、以及血栓与止血的临床与基础研究三个方面为主要研究方向。造血干细胞移植方面:主要从事造血干细胞移植的细胞免疫及病理机制研究,研究细胞免疫在造血干细胞移植前后的变化、细胞免疫在移植排异发生、移植后抗白血病效应中的作用机制,实现基础到临床的转化。高危与难治急性白血病方面:主要寻找白血病出现耐药的机制研究,从基因组学与蛋白组学角度如何调控或逆转白血病的耐药,寻找药物作用靶点,以及为靶向药物的研发提供依据。 血栓与止血疾病方面:主要开展血友病的基因治疗研究(血友病患者体内缺少一种凝血因子从而出血不止),从动物模型的角度,如何进行目的基因的改造、如何选择载体及靶基因等,为临床进行血友病的基因治疗提供依据。"目前正在承担的科研项目(仅限于主要负责人)项目名称、来源、经费指标卡号 总经费(万元) 起止日期1. IL-12/IL-12R与CCR5通过JAK/STAT通路相互调控对分离aGVHD与GVL的机制研究近期论文
1.Zheng CC, Zhu XY, Tang BL, Zhang XH, Zhang L, Geng LQ, Liu HL, Sun ZM. Double vs. single cord blood transplantation in adolescent and adult hematological malignancies with heavier body weight (≥50kg). Hematology. 2018 Mar; 23(2):96-104. (第一作者)2.Zheng CC, Zhu X, Tang B, Zhang X, Zhang L, Geng L, Liu H, Sun Z. Transplants of unrelated cord blood or sibling allogeneic peripheral blood stem cells/bone marrow in adolescent and young adults with chronic myeloid leukemia: comparable outcomes but better chronic GVHD-free and relapse-free survival among survivors with cord blood. Oncotarget. 2017 Dec 5;9(2):2848-2857. (第一作者)3.Zheng CC, Tang B, Zhu X, Zhang X, Zhang L, Geng L, Liu H, Sun Z. Pre-engraftment bloodstream infections in acute leukemia patients undergoing unrelated cord blood transplantation following intensified myeloablative conditioning without ATG. Ann Hematol. 2017 Jan; 96(1):115-124.(第一作者)4.Zheng CC, Zhu XY, Tang BL, Zhang XH, Zhang L, Geng LQ, Liu HL, Sun ZM. Clinical separation of cGvHD and GvL and better GvHD-free/relapse-free survival (GRFS) after unrelated cord blood transplantation for AML. Bone Marrow Transplant. 2017 Jan; 52(1):88-94.(第一作者)5.Zheng CC, Zhu X, Tang B, Zhang L, Geng L, Liu H, Sun Z.The impact of pre-transplant minimal residual disease on outcome of intensified myeloablative cord blood transplant for acute myeloid leukemia in first or second complete remission. Leuk Lymphoma. 2016 Jun; 57(6):1398-405.(第一作者)6.Zheng CC, Luan Z, Fang J, Sun X, Chen J, Li CK, Hu S, Zhu Y, Sun Z.Comparison of conditioning regimens with or without antithymocyte globulin for unrelated cord blood transplantation in children with high-risk or advanced hematological malignancies. Biol Blood Marrow Transplant. 2015 Apr; 21(4):707-712. (第一作者)7.Zheng CC, Zhu X, Tang B, Yao W, Song K, Tong J, Geng L, Liu H, Sun Z. Comparative analysis of unrelated cord blood transplantation and HLA-matched sibling hematopoietic stem cell transplantation in children with high-risk or advanced acute leukemia. Ann Hematol, 2015 Mar; 94(3):473-480.(第一作者)8.Zheng CC, Liu X, Zhu W, Cai X, Wu J, Sun Z.Tailored central nervous system-directed treatment strategy for isolated CNS recurrence of adult acute myeloid leukemia. Hematology, 2014 Jun;19(4):208-212.(第一作者)9.Zheng CC, Tang B, Yao W, Tong J, Zhu X, Song K, Geng L, Liu H, Sun Z.Comparison of unrelated cord blood transplantation and HLA-matched sibling hematopoietic stem cell transplantation for patients with chronic myeloid leukemia in advanced stage. Biol Blood Marrow Transplant, 2013 Dec; 19(12):1708-1712.(第一作者)10.Zheng CC, Tang B, Tong J, Liu H, Geng L, Wang X, Ding K, Sun Z.Unrelated cord blood transplantation for central nervous system relapse in high-risk childhood acute lymphoblastic leukemia. Ann Hematol, 2013 Dec; 92(12):1665-1673. (第一作者)附属第一医院血液科行政副主任、出凝血亚专科主任;亚太医学生物免疫学会理事;中华医学会血液学分会血栓与止血学组委员 相关热点
最新收录
- 水咲优美(水咲優美) 06-25
- 三月光(三月ひかる) 06-21
- 澪川遥(澪川はるか) 06-21
- 冈本莉里 岡本莉里 (おか 06-21
- 宗像丽奈(宗像れな) 06-21
- 温碧霞 06-21
- 舒淇 06-21
- 叶玉卿 06-21
- 叶子楣 06-21
- 杨思敏 06-21