个人简历

汤朝晖，男，1976年9月生，研究员，博士生导师。中国科学院长春应用化学研究所生态环境高分子材料重点实验室生物医用高分子课题组。曾在英国帝国理工学院和美国纽约州立大学石溪分校做博士后。目前主要从事高分子载体抗肿瘤纳米药物研究。针对传统抗肿瘤纳米药物存在的渗透和靶向能力低等问题，提出了肿瘤“边缘与中心”协同治疗和“凝血靶向”等的纳米药物研究新思路，发现纳米技术可以显著提高血管阻断剂的的肿瘤血管靶向性和抑瘤能力，把纳米药物的瘤内渗透能力低从“缺点”转变为“优势”。在Advanced Materials、Advanced Science、Progress in polymer science、Chemical Science、Biomaterials、Journal of controlled release等知名期刊发表学术论文100余篇，SCI他引3000余次，申请中国发明专利40余项，其中已授权专利30 余项，申请PCT专利2项，获授权美国专利1项。2007和2011年两次获得吉林省科技进步一等奖，2011年获得中国石油与化学工业联合会技术发明奖一等奖，2013年获中国专利优秀奖，2015年入选中国科学院青年创新促进会“优秀会员”。所开发的聚谷氨酸接枝聚乙二醇顺铂纳米胶束药物实现了技术转让。
教育经历:
1995-1999，湘潭大学，应用化学，本科
1999-2004，中科院长春应用化学研究所，高分子化学专业，硕博连读，导师：陈学思
工作经历:
2005-2006，英国帝国理工学院，博士后，合作导师：Vernon C. Gibson
2007-2008，美国纽约州立大学石溪分校，博士后，合作导师：Benjamin Chu和Benjamin S. Hsiao
2009-2014，中科院长春应用化学研究所，副研究员
2015-现在，中科院长春应用化学研究所，研究员

研究领域

生物医用高分子，抗肿瘤纳米药物，肿瘤免疫治疗""

近期论文

1) Wang, Y.; Yu, H.; Zhang, D.; Wang, G.; Song, W.; Liu, Y.; Ma, S.; Tang, Z.; Liu, Z.; Sakurai, K.; Chen, X., Co-administration of combretastatin A4 nanoparticles and sorafenib for systemic therapy of hepatocellular carcinoma. Acta Biomater. 2019, 92, 229-240.
2) Qin, H.; Yu, H.; Sheng, J.; Zhang, D.; Shen, N.; Liu, L.; Tang, Z.; Chen, X., PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly(l-Glutamic Acid)-Combretastatin A4 Conjugate in Metastatic Breast Cancer. Advanced Science 2019, 6 (12), 1900327.
3) Yang, S.; Tang, Z.; Hu, C.; Zhang, D.; Shen, N.; Yu, H.; Chen, X., Selectively Potentiating Hypoxia Levels by Combretastatin A4 Nanomedicine: Toward Highly Enhanced Hypoxia-Activated Prodrug Tirapazamine Therapy for Metastatic Tumors. Adv. Mater. 2019, 31 (11), 1805955.
4) Zhou, H.; Lv, S.; Zhang, D.; Deng, M.; Zhang, X.; Tang, Z.; Chen, X., A polypeptide based podophyllotoxin conjugate for the treatment of multi drug resistant breast cancer with enhanced efficiency and minimal toxicity. Acta Biomater. 2018, 73, 388-399.
5) Zhou, H.; Sun, H.; Lv, S.; Zhang, D.; Zhang, X.; Tang, Z.; Chen, X., Legumain-cleavable 4-arm poly(ethylene glycol)-doxorubicin conjugate for tumor specific delivery and release. Acta Biomater. 2017, 54, 227-238.
6) Liu, T.; Zhang, D.; Song, W.; Tang, Z.; Zhu, J.; Ma, Z.; Wang, X.; Chen, X.; Tong, T., A poly(l-glutamic acid)-combretastatin A4 conjugate for solid tumor therapy: Markedly improved therapeutic efficiency through its low tissue penetration in solid tumor. Acta Biomater. 2017, 53, 179-189.
7) Wang, Y.; Lv, S.; Deng, M.; Tang, Z.; Chen, X., A charge-conversional intracellular-activated polymeric prodrug for tumor therapy. Polym. Chem. 2016, 7, 2253-2263.
8) Tang, Z.; He, C.; Tian, H.; Ding, J.; Hsiao, B. S.; Chu, B.; Chen, X., Polymeric nanostructured materials for biomedical applications. Prog. Polym. Sci. 2016, 60, 86-128.
9) Song, W.; Tang, Z.; Zhang, D.; Wen, X.; Lv, S.; Liu, Z.; Deng, M.; Chen, X., Solid Tumor Therapy Using a Cannon and Pawn Combination Strategy. Theranostics 2016, 6 (7), 1023-1030.
10) Song, W.; Tang, Z.; Zhang, D.; Li, M.; Gu, J.; Chen, X., A cooperative polymeric platform for tumor-targeted drug delivery. Chemical Science 2016, 7 (1), 728-736.
11) Song, W.; Tang, Z.; Shen, N.; Yu, H.; Jia, Y.; Zhang, D.; Jiang, J.; He, C.; Tian, H.; Chen, X., Combining disulfiram and poly(l-glutamic acid)-cisplatin conjugates for combating cisplatin resistance. J. Control. Release 2016, 231, 94-102.
12) Song, W.; Tang, Z.; Lei, T.; Wen, X.; Wang, G.; Zhang, D.; Deng, M.; Tang, X.; Chen, X., Stable loading and delivery of disulfiram with mPEG-PLGA/PCL mixed nanoparticles for tumor therapy. Nanomed. Nanotechnol. Biol. Med. 2016, 12 (2), 377-86.
13) Niu, Y.; Song, W.; Zhang, D.; Tang, Z.; Deng, M.; Chen, X., Functional computer-to-plate near-infrared absorbers as highly efficient photoacoustic dyes. Acta Biomater. 2016, 43, 262-8.
14) Yu, H.; Tang, Z.; Zhang, D.; Song, W.; Zhang, Y.; Yang, Y.; Ahmad, Z.; Chen, X., Pharmacokinetics, biodistribution and in vivo efficacy of cisplatin loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) complex nanoparticles for tumor therapy. J. Control. Release 2015, 205, 89-97.
15) Song, W.; Tang, Z.; Zhang, D.; Yu, H.; Chen, X., Coadministration of Vascular Disrupting Agents and Nanomedicines to Eradicate Tumors from Peripheral and Central Regions. Small 2015, 11 (31), 3755-3761.
16) Shi, C.; Yu, H.; Sun, D.; Ma, L.; Tang, Z.; Xiao, Q.; Chen, X., Cisplatin-loaded polymeric nanoparticles: Characterization and potential exploitation for the treatment of non-small cell lung carcinoma. Acta Biomater. 2015, 18, 68–76.
17) Song, W.; Tang, Z.; Zhang, D.; Zhang, Y.; Yu, H.; Li, M.; Lv, S.; Sun, H.; Deng, M.; Chen, X., Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin. Biomaterials 2014, 35 (9), 3005-3014.
18) Song, W.; Tang, Z.; Li, M.; Lv, S.; Sun, H.; Deng, M.; Liu, H.; Chen, X., Polypeptide-based combination of paclitaxel and cisplatin for enhanced chemotherapy efficacy and reduced side-effects. Acta Biomater. 2014, 10 (3), 1392-1402.