个人简历

李博峰，特任研究员，博士生导师。
1997年至2001年就读于厦门大学生命科学学院，获得生物学学士学位。2001年至2006年就读于中国科学技术大学生命科学院，获得细胞生物学博士学位。后赴美深造，先后在美国芝加哥大学病理系（2006-2009）和美国St.jude儿童研究医院病理系（2009-2018）从事博士后研究工作。2018年12月加入中国科技大学，任科大生命科学院和附属第一医院双聘特任研究员。主要从事自身免疫性疾病和肿瘤的基础科学研究,从分子、细胞及动物模型水平研究细胞因子信号通路维持免疫耐受和免疫平衡的机制。
在Hepatology 和Nature Communications等杂志上发表文章10余篇。Web of Science学术他引总数超过500次。研究成果曾入选<<科技导报>>“2006年中国重大科学进展”（共30项，其中生命科学领域7项），并获得中国科学院院长优秀奖。

研究领域

1 细胞因子在自身免疫疾病中的特异性调控作用
2 肿瘤免疫治疗及新靶点发现
3 重要免疫相关蛋白及其抗体的检测与功能验证""

近期论文

1. Koelink PJ , Bloemendaal FM, Bofeng Li, Westera L, Vogels EM, van RM, Gloudemans AK, van 't Wout AB, Korf H, Vermeire S, Velde AA, Ponsioen CY, D'Haens GR, Verbeek JS, Geiger TL, Wildenberg ME, van den Brink GR. “Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling.” Gut. 2019 Sep 10.（[Epub ahead of print）
2. Wei H, Sun A, Bofeng Li，Guo F. Interleukin10 Family Cytokines Immunobiology and Structure. Adv Exp Med Biol. 2019;1172:79-96.
3. Zahid A, Bofeng Li, Kombe AJK, Jin T, Tao J. Pharmacological Inhibitors of the NLRP3 Inflammasome. Front Immunol. 2019;10:2538.
4. Bofeng Li, Jones LL, Geiger TL. “IL-6 Promotes T Cell Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORgammat Expression.”Journal of Immunology. 2018. 201:2934-2946.
5 Jones LL, Alli R, Bofeng Li, Geiger TL.“Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.”Journal of Immunology. 2016. 196:2973-2985.
6. Zhao Y, Nguyen P, Vogel P, Bofeng Li, Jones LL, Geiger TL. “Autoimmune susceptibility imposed by public TCRβ chains.” Scientific Reports. 2016. 21:37543.
7. Bofeng Li, Gurung P, Malireddi RK, Vogel P, Kanneganti TD, Geiger TL.“IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.” Nature Communications. 2015. 6:6131.
8. Gurung P, Bofeng Li, Malireddi RK, Lamkanfi M, Geiger TL, Kanneganti TD.“Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation.” Scientific Reports. 2015. 5:14488.
9. Bofeng Li, Alli R, Vogel P, Geiger TL.“IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis.”Mucosal Immunology. 2014. 7:869-878.
10. Tauro S, Nguyen P, Bofeng Li, Geiger TL.“Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis.”European Journal of Immunology. 2013. 43:1195-1207.
11. Savage AK, Constantinides MG, Han J, Picard D, Martin E, Bofeng Li, Lantz O, Bendelac A.“The transcription factor PLZF directs the effector program of the NKT cell lineage.”Immunity. 2008. 29:391-403.
12. Wei HX, Chuang YH, Bofeng Li, Wei H, Sun R, Moritoki Y, Gershwin EM, Lian ZX, Tian Z.“CD4+CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice.”Journal of Immunology. 2008. 181:7221-7229.
13. Bofeng Li, Sun R, Wei H, Gao B, Tian Z.“Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism.”Hepatology. 2006. 43:1211-1219.