个人简历

Jan.2006 – present professor, Department of Chemistry and Hefei National Laboratory for Physices at Microsacle, USTC, Hefei, China;\r
Oct.2003 - Sep.2004 Alexander von Humboldt research fellow, Ludwig-Maximilians-Universität München, Department Chemie, Ludwig-Maximilians-Universität, Munich, Germany;\r
Dec.2001 - Dec.2005 Professor, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China;\r
Dec.2000 - Nov.2001 Associate Professor, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China;\r
Jun.1998 - Jun.2000 Visiting Scholar (Joint PhD candidate), The University of Virginia, Charlottesville, VA, USA.\r
Sept.1996 - Jul.2000 PhD candidate, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China;\r
Sept.1993 - Jul.1996 M.Sc, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China;\r
Sept.1989 - Jul.1993 B.S. candidate, Henan Normal University, China.

研究领域

""Organocatalysis\r
The development of new chiral organocatalysts and asymmetric multicomponent reactions is main focus of our research. We have designed chiral prolinamide-type catalysts, which are so far the most efficient organocatalysts for asymmetric direct aldol reactions, and proposed “enamine-double hydrogen-bonding” activation mode, which is quite generally applicable and inspirable for the design of a big family of amino amide catalysts. We have identified that chiral BINOL-based bisphosphoric acids show unique capacity to drive enantioselective 1,3-dipolar cycloaddition. Our great interest in the development of chiral Brønsted acid-catalyzed MCRs has led to highly enantioselective Biginelli-type reactions, 1,3-dipolar cycloadditions and other annulation reactions.\r
\r
Transition metal catalysis\r
Catalytic enantioselective C-H functionalization and transformations of olefins have long been our research focuses in metal catalysis. We have designed chiral bimetallic oxovanadium catalysts, which have enabled highly enantioselective oxidative coupling of naphthol derivatives. Recently, we adopted chiral anions, such as chiral phosphates and anionic stereogenic-at-metal complexes, to the metal-mediated C(sp3)-H functionalization and asymmetric transformation of olefins. Notably, we have found that the 3,3’-disubstituted BINOL-based phosphoramidites are excellent chiral ligands for transition metal-catalyzed asymmetric allylic C-H functionalization reactions and proposed a “concerted proton and two-electron transfer” process via which the allylic C-H cleaving event may occur.\r
\r
Organo-metal combined catalysis\r
The asymmetric organocatalysis combined with metal catalysis integrates the catalytic activity of metals and organocatalysts to allow the simultaneous or sequential occurrence of multiply bond-breaking and forming events in stereochemical control, and thereby enables asymmetric transformations that are unable to offer high levels of enantioselectivity by virtue of either of the individual chiral catalysts. In 2001, our group first described an asymmetric allylic alkylation of glycine imino esters with allyl acetate cooperatively catalyzed by palladium complexes and chiral ammonium salts. In this proof of concept, the oxidative addition of palladium complexes to allyl acetate generates π-allylic fragments, while the chiral ammonium salts are actually responsible for controlling the stereoselectivity by formation of chiral ion pairs with nucleophiles. Over the last decade, our group have discovered a variety of binary catalytic systems consisting of metals (including Au, Pd, Cu, Rh, Ni, etc.) and chiral organocatalysts (including chiral Brønsted acids, chiral Lewis bases and others) in either cooperative or relay catalysis manner, culminating in many unprecedented asymmetric transformations.(Liu-Zhu Gong, Asymmetric Organo-Metal Catalysis: Concepts, Principles, and Applications,(2022))"""Organocatalysis\r
The development of new chiral organocatalysts and asymmetric multicomponent reactions is main focus of our research. We have designed chiral prolinamide-type catalysts

近期论文

Photochemical Allylation of Alkanes Enabled by Nickel Catalysis Youxiang Jin, Elvis Wang Hei Ng, Tao Fan, Hajime Hirao* and Liu-Zhu Gong* ACS Catal. 2022, 12, 10039−10046\r
\r
Palladium-catalysed branch- and enantioselective allylic C–H alkylation of α-alkenes Zhong-Sheng Nong, Ling Zhu, Tian-Ci Wang, Lian-Feng Fan, Pu-Sheng Wang & Liu-Zhu Gong Nat. Synth. 1, 487–496 (2022)\r
\r
A practical FeCl3/HCl photocatalyst for versatile aliphatic C–H functionalization Zhen-Yao Dai, Shuo-Qing Zhang, Xin Hong, Pu-Sheng Wang,Liu-Zhu Gong Chem Catalysis 2, 1211–1222\r
\r
Photoinduced and Palladium-Catalyzed Hydrogen Atom Transfer Triggered 1,2-Difunctionalization of 1,3-Dienes with Hydroxamides Xiao-Yun Ruan, Tao Zhang, Wen-Ao Li, Yi-Zhuo Yin, Zhi-Yong Han, Liuzhu Gong Sci China Chem May (2022) Vol.65 No.5\r
\r
Stereodivergent propargylic alkylation of enals via cooperative NHC and copper catalysis Yu-Hua Wen, Zi-Jing Zhang, Shuai Li, Jin Song, Liu-Zhu Gong Nat. Commun. 13, 1344 (2022).\r
\r
Asymmetric Redox Allylic Alkylation to Access 3,3՛-Disubstituted Oxindoles Enabled by Ni/NHC Cooperative Catalysis Tao Fan, Jin Song, Liu-Zhu Gong Angew. Chem.Int. Ed. 2022, 61, e202201678\r
\r
Organo/Transition-Metal Combined Catalysis Rejuvenates Both in Asymmetric Synthesis Dian-Feng Chen and Liu-Zhu Gong J. Am. Chem. Soc. 2022, 144, 2415–2437\r
\r
Palladium-Catalyzed Cascade C−H Functionalization/ Asymmetric Allylation Reaction of Aryl α-Diazoamides and Allenes: Lewis Acid Makes a Difference Min-Song Wu, Xiao-Yun Ruan, Zhi-Yong Han, Liu-Zhu Gong Chem.Eur.J. 2022, 28, e202104218\r
\r
Modular access to chiral cyclopentanes via formal [2+2+1] annulation enabled by palladium/chiral squaramide relay catalysis Lian-Feng Fan, Rui Liu, Pu-Sheng Wang, Liu-Zhu Gong Tetrahedron Chem 1 (2022) 100002\r
\r
Access to chiral homoallylic vicinal diols from carbonyl allylation of aldehydes with allyl ethers via palladium-catalyzed allylic C-H borylation Tian-Ci Wang, Pu-Sheng Wang, Dian-Feng Chen and Liu-Zhu Gong Sci. China Chem. 2022, 65: 298–303.\r
\r
Palladium-Catalyzed Enantioselective C(sp3)–H/C(sp3)–H Umpolung Coupling of N-Allylimine and α-Aryl Ketones Tian-Ci Wang, Ling Zhu, Shiwei Luo, Zhong-Sheng Nong, Pu-Sheng Wang and Liu-Zhu Gong J. Am. Chem. Soc. 2021, 143, 20454−20461\r
\r
Asymmetric C–H Functionalization Enabled by Pd/Chiral Phosphoric Acid Combined Catalysis Pu-Sheng Wang, Liu-Zhu Gong Synthesis 2021 Published online: 06.10.2021\r
\r
Enantioselective Formal [4 + 3] Annulations to Access Benzodiazepinones and Benzoxazepinones via NHC/Ir/Urea Catalysis Yang-Yang Li，Shuai Li, Tao Fan, Zi-Jing Zhang, Jin Song and Liu-Zhu Gong ACS Catal. 2021, 11, 14388−14394\r
\r
Chiral Indoline-2-carboxylic Acid Enables Highly Enantioselective Catellani-type Annulation with 4-(bromomethyl)cyclohexanone Xin-Meng Chen, Ling Zhu, Dian-Feng Chen, Liu-Zhu Gong Angew. Chem. Int. Ed. 2021, 60, 24844-24848.\r
\r
Atroposelective sp3C-H Coupling for Kinetic Resolution of Thioanilide Atropisomers Hua-Jie Jiang, Rui-Long Geng, Jia-Hui Wei, Liu-Zhu Gong Chin. J. Chem. 2021, 39, 3269-3276 .\r
\r
Access to chiral γ-butenolides via palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes Zhen-Yao Dai, Pu-Sheng Wang, Liu-Zhu Gong Chem. Commun., 2021,57, 6748-6751\r
\r
Platinum-Catalyzed Allylic C–H Alkylation with Malononitriles Lian-Feng Fan , Pei-Pei Xie, Pu-Sheng Wang, Xin Hong and Liu-Zhu Gong CCS Chem. 2021, 3, 1166–1175\r
\r
Counteranion-controlled regioselectivity in palladium-catalyzed allylic amination of dienyl allylic carbonates Meng-Lan Shen, Pu-Sheng Wang, Liu-Zhu Gong Tetrahedron 2021, 84, 131996-131999\r
\r
Nickel-catalyzed Enantioselective Desymmetrizing Aza-Heck Cyclization of Oxime Esters Hong-Cheng Shen, Ying Chen, Ying Zhang, He-Ming Jiang, Wen-Qian Zhang, Wen-Ao Li, Mostafa Sayed, Xinhao Zhang, Yun-Dong Wu and Liu-Zhu Gong CCS Chem. 2021,3, 421-430\r
\r
Asymmetric α-Pentadienylation of Aldehydes with Cyclopropylacetylenes Min-Song Wu, Zhi-Yong Han and Liu-Zhu Gong Org. Lett. 2021, 23, 636–641