个人简历
教育背景: 博士 2004 中国科学院水生生物研究所 学士 1998 河北大学生物系 研究经历: 2009-现在 教授 中国海洋大学医药学院分子医学生物学研究室 2006-2008 博士后/访问学者 Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor 2004-2006 助理研究员、副研究员 中国科学院武汉植物园
研究领域
利用斑马鱼为模型开展基础分子医学生物学研究，研究集中在发现与疾病和发育有关的新功能基因和新信号通路并建立人类疾病的斑马鱼疾病模型。
近期论文
1.Bai Y*, Tan X*, Zhang H*, Liu C, Zhao, B, Li Y, Lu L, Liu Y, Zhou J# (2014) Ror2 receptor mediates Wnt11 signaling and affects convergence and extension movements in zebrafish. J Biol Chem jbc.M114.586099. 2.Rong X*, Chen C*, Zhou P, Zhou Y, Li Y, Lu L, Liu Y, Zhou J#, Duan C# (2014) R-spondin 3 regulates dorsoventral patterning and anteroposterior formation by antagonizing Wnt/β-catenin signaling pathway in zebrafish embryos. PLoS One 9(6):e99514. 3.Liu C, Luan J, Bai Y, Li Y, Lu L, Liu Y, Hakuno F, Takahashi S, Duan C, Zhou J# (2014) Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos. Gen Comp Endocrinol. 197:82-91. 4.Zhou J, Xiang J, Zhang S, Duan C. (2013) Structural and functional analysis of the amphioxus IGFBP gene uncovers ancient origin of IGF-independent functions. Endocrinology 154(10):3753-63. 5.Kjaer-Sorensen K, Engholm DH, Kamei H, Morch MG, Kristensen AO, Zhou J, Conover CA, Duan C, Oxvig C. (2013) Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity. J Biol Chem. 288(14):9982-92. 6.Feng Q, Zou X, Lu L, Li Y, Liu Y, Zhou J#, Duan C#. (2012) The stress-response gene redd1 regulates dorsoventral patterning by antagonizing Wnt/β-catenin activity in zebrafish. PLoS One 7(12):e52674. 7.Jiao S, Ren H, Li Y, Zhou J, Duan C, Lu L. (2013) Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells. Mol Cell Biochem 373(1-2):107-13. Zhang P, Lu L, Yao Q, Li Y, Zhou J, Liu Y, Duan C. (2012) Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3α. Am J Physiol Regul Integr Comp Physiol 303(11):R1165-74. 8.Zhang C, Lu L, Li Y, Wang X, Zhou J, Liu Y, Fu P, Gallicchio MA, Bach LA, Duan C. (2012) IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. Int J Cancer 130(9):2003-12. 9.Zhong Y, Lu L, Zhou J, Li Y, Liu Y, Clemmons DR, Duan C. (2011) IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos. J Cell Sci 124:1925-35. 10.Jiao S, Dai W, Lu L, Liu Y, Zhou J, Li Y, Korzh V, Duan C. (2011) The conserved clusterin gene is expressed in the developing choroid plexus under the regulation of notch but not IGF signaling in zebrafish. Endocrinology 152:1860-71. 11.Zhou J, Li W, Kamei H, Duan C. (2008) Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. PLoS One 3(12):e3926.
