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徐涛
2023-05-16 12:25
  • 徐涛
  • 徐涛 - 教授-中国海洋大学-医药学院-个人资料

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""To realize a strategic use of modern inert bond activation in bioactive natural product synthesis would greatly increase the overall efficiency in total synthesis. Our group main research will be placing on building a bridge between methodologies involving/but not limited to transition-metal-catalysis and total synthesis. Our synthesis philosphy is to use TM-catalyzed inert bond (C-X bond, X=C, O, N etc.) activation to construct skeletons while leaving the functional group decoration to C-H bond activation methodology in the late stage of synthesis. Base on these guidelines, our group research will be devoted to the following areas:\r
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(1) Developing new type of rearrangement strategies that is directed towards highly efficient synthesis of fused- and bridged-ring frameworks;\r
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(2) Applying the aforementioned methodology as strategical key step for core skeleton assembly in complex natural product synthesis;\r
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(3) Evaluation of synthesized bioactive molecules/samples for medicinal development and probing its metabolic regulation ability towards oncogenesis;""""

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