王鑫
近期热点
资料介绍
个人简历
中国海洋大学医药学院“英才”一层次教授、博士生导师;青岛海洋科学与技术国家实验室海洋药物平台研究员、项目科学家。 2004年获复旦大学生物学学士学位、2010年获复旦大学微生物学博士学位。2010年9月– 2014年4月 美国宾夕法尼亚大学医学院博士后;2014年 4月– 2017年8月 美国克利夫兰医学中心博士后。2017年 9 月作为“英才”一层次教授加入中国海洋大学医药学院与海洋国家实验室海洋药物平台。研究领域
主要研究为包含大部分肿瘤病毒在内的DNA病毒与宿主的相互关系。在首次提出并证明了肿瘤病毒HPV和MCV利用宿主蛋白Brd4进行病毒复制并逃避宿主免疫监控,并提出Brd4与DNA损伤修复相关。近期论文
1. Wang X, Majumdar T, Kessler P, Ozhegov E, Zhang Y, Chattopadhyay S, Barik S and Sen GC, 2016. STING requires TRIF to trigger innate immune response to microbial infection. Cell Host & Microbe . (2016); 14;20(3):329-341. (IF=12.6) 2. Wang X, Li J, Schowlter RM, Jiao J, Buck CB, You J. Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication. PLoS Pathogens. (2012); 8(11):e1003021.. (IF=9.1) 3. Wang X, Helfer CM, Pancholi N, Bradner JE, You J, Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA. J Virol. (2013); 87: 3871-3884.(IF=5.1) 4. Tsang S#, Wang X#, Li J, Buck CB, You J. Host DNA damage response factors localize to Merkel cell polyomavirus DNA replication sites to support efficient viral DNA replication. J Virol. (2014); 88(6):3285-97. (# 共同第一作者). (IF=5.1) 5. Wu X, Ming T, Wang X, Wang P, Wang J, Chen J. High-photoluminescence-yield gold nanocubes: for cell imaging and photothermal therapy. ACS Nano. (2010); 4:113-120. (IF=12.2) 6. Wang X, Li L, Ding S, Huang X, Zhang J, Yin J, Zhong J. Chicken HS4 insulator significantly improves baculovirus-mediated foreign gene expression in insect cells by modifying the structure of neighbouring chromatin in virus minichromosome. J. Biotech. (2009); 142: 193-199. (IF=3.0) 7. Wang X, Yin J, Huang X, Zhong J. DNA methyltransferase inhibitors increase baculovirus-mediated gene expression in mammalian cells when applied before infection. Anal. Biochem. (2009); 396: 322-324. (IF=3.3) 8. Li J, Wang X, Diaz J, Tsang SH, Buck CB, You J. Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation. J Virol. (2013); 87(16):9173-9188. (IF=5.1) 9. Li J, Diaz J, Wang X, Tsang SH, You J. Phosphorylation of Merkel cell polyomavirus large T antigen at Serine 816 by ATM kinase induces apoptosis in host cells. J Bio Chem. (2014); 290 (3):1874-1884. (IF=4.1) 相关热点
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