个人简历

主要成果：
研究成果在PLoS Genetics，ACS Synthetic Biology，Applied and Environmental Microbiology，Journal of Bacteriology等领域内高水平杂志发表，授权专利1项；入选2016年中国科协“青年人才托举工程”，获得2014年山东省优秀博士论文。

研究领域

海洋资源微生物多样性与开发；细菌遗传及群体感应与群体感应淬灭的调控机制""

近期论文

Yong Han＆, Wang Yan＆,Yameng Yu, Haotong Chen, Yuemao Shen, Liangcheng Du,2017.Indole-induced Reversion of Intrinsic Multi-antibiotic Resistance in Lysobacter enzymogenes. Applied and Environmental Microbiology.17;83(17). pii: e00995-17（co-first author） Wang Yan, Hui Li, Xinxin Cui& Xiao-Hua Zhang*,2017.A novel stress response mechanism, triggered by indole,involved in quorum quenching enzyme MomL and iron-sulfur cluster in Muricauda olearia Th120. Scientific Reports 26;7(1):4252 ( doi:10.1038/s41598-017-04606-8) Zhuo Li＆, Wang Yan＆, Zhang Zheng, Li Jian, Zhang Xiao-Hua, Li Yue-zhong, 2017. Myxococcus xanthus DK1622 coordinates expressions of the duplicate groEL and single groES genes for synergistic functions of GroELs and GroES. Frontiers in Microbiology. (doi: 10.3389/fmicb.2017.00733)（co-first author） Wang Yan, Qinghao Song, Xiao-Hua Zhang*. 2016. Marine Microbiological Enzymes: Studies with Multiple Strategies and Prospects. Marine Drugs, 14(10), 171; doi:10.3390/md14100171. Qinghao Song, Wang Yan*, Chong Yin, Xiao-Hua Zhang*. 2016. LaaA, a novel cold-adaptive alkalophilic alpha-amylase from deep-sea bacterium Luteimonas abyssiXH031. Enzyme and Microbial Technology, DOI:10.1016/j.enzmictec.2016.05.003 (corresponding author) Li Zhang＆, Wang Yan＆, Jing Liang, Qinghao Song, Xiao-Hua Zhang*. 2016.Degradation properties of various macromolecules of cultivable psychrophilic bacteria from the deep sea water of the South Pacific Gyre. Extremophiles, DOI: 10.1007/s00792-016-0856-4 (co-first author) Wang Yan, Xiaojing Chen, and Yue-zhong Li*. 2016. Duplicated groEL genes in Myxococcus xanthus DK1622. Stress and Enviromental Regulation of Gene Expression and Adaptation in Bacteria, chapter 14.5. Han Y＆, Wang Yan＆, Simon Tombosa, Stephen Wright, Justin Huffman, Gary Yuen, Guoliang Qian, Fengquan Liu, Yuemao Shen, Liangcheng Du. 2015. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Appl Microbiol Biotechnol, 99(2):801-11. (co-first author) Wang Yan.＆, X. Li＆, W. Zhang, X. Zhou, and Y. Z. Li. 2014. The groEL2 gene, but not groEL1, is required for biosynthesis of the secondary metabolite myxovirescin in Myxococcus xanthus DK1622. Microbiology 160:488-495. Wang Yan＆, W. Y. Zhang＆, Z. Zhang, J. Li, Z. F. Li, Z. G. Tan, T. T. Zhang, Z. H. Wu, H. Liu, and Y. Z. Li. 2013. Mechanisms Involved in the Functional Divergence of Duplicated GroEL Chaperonins in Myxococcus xanthus DK1622. PLoS Genetics 9:e1003306. Wang Yan,G. Qian, F. Liu, Y. Z. Li, Y. Shen, and L. Du. 2013. Facile method for site-specific gene integration in Lysobacter enzymogenes for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF. ACS Synth Biol 2:670-678. (ACS Synthetic Biology launched on 2012, IF: 6.1) Wang Yan＆, Qian, GL.＆, Li, YY., Wang, YS., Wang, YL., Wright Stephen, Li, YZ., Shen, YM., Liu, FQ., Du, LC. 2013. Biosynthetic mechanism for sunscreen of the biocontrol agent lysobacter enzymogenes. PLoS One 8(6): e66633.doi:10.1371/journal.pone.0066633. (Cited by Cell) Zhang, W., Y. Li, G. Qian, Wang Yan, H. Chen, Y. Z. Li, F. Liu, Y. Shen, and L. Du. 2011. Identification and characterization of the anti-methicillin-resistant Staphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes OH11. Antimicrob Agents Chemother 55:5581-5589. Li, J.＆, Wang Yan＆, C. Y. Zhang, W. Y. Zhang, D. M. Jiang, Z. H. Wu, H. Liu, and Y. Z. Li. 2010. Myxococcus xanthus viability depends on groEL supplied by either of two genes, but the paralogs have different functions during heat shock, predation, and development. Journal of Bacteriology 192:1875-1881. (co-first author) Li Zhuo, Wang Yan, Zheng Zhang, and Yue-Zhong Li. Dynamic Interplay of the Myxobacterial Chaperonins. Prokaryotic Chaperonins: multiple copies and multitude functions 2017, Springer