个人简历

1983-1987年毕业于南开大学化学系； 1987-1990年毕业于南开大学元素有机化学研究所，获理学硕士学位； 1990-1998年任职于华北制药集团公司抗生素研究所，工程师； 1998-2001年毕业于中国医学科学院, 北京协和医科大学药物研究所，获博士学位； 2002-2005年于香港理工大学应用生物学和化学科技系从事研究工作，研究助理； 2005年至今，任职于中国海洋大学医药学院，教授； 2008年3月-2009年2月期间作为访问学者于香港理工大学应用生物学和化学科技系从事研究工作。

研究领域

本实验室主要是针对肿瘤耐药、超级细菌等，通过计算机辅助药物设计、化学合成等手段，进行药物结构设计合成及以天然产物（尤其是海洋天然产物）中具有抗肿瘤多药耐药及抗耐药菌等生物活性的小分子为研究对象，系统地进行结构改造和构效关系研究。

近期论文

Dong-Dong Luo, Kai Peng, Jia-Yu Yang, Pawinee Piyachaturawat, Witchuda Saengsawang, Lei Ao, Wan-Zhou Zhao, Yu Tang*, Sheng-biaoWan*. Structural modification of oridonin via DAST induced rearrangement. RSC Adv. 2018, 8(52): 29548–29554. Chao Yang, Iris L.K. Wong, Kai Peng, Zhen Liu, Peng Wang, Tingfu Jiang, Tao Jiang, Larry M.C. Chow, Sheng-Biao Wan*. Extending the structureactivity relationship study of marine natural ningalin B analogues as P-glycoprotein inhibitors. Eur J Med Chem, 2017, 125, 795−806. Iris L. K. Wong, Bao-Chao Wang, Jian Yuan, Liang-Xing Duan, Zhen Liu, Tao Liu, Xue-Min Li, Xuesen Hu, Xiao-Yu Zhang, Tao Jiang, Sheng-Biao Wan*, and Larry M. C. Chow*. Potent and Nontoxic Chemosensitizer of P-Glycoprotein-mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives. J Med Chem, 2015, 58, 4529−4549. Chiou J., Wan S., Chan K. F., So P. K., He D., Chan E. W., Chan T.H., Wong K.Y., Tao J., Chen S. Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).ChemCommun, 2015, 51(46), 9543-6. Zhen Wang, Iris L. K. Wong, Fu Xing Li, Chao Yang, Zhen Liu, Tao Jiang, Ting Fu Jiang, Larry M. C. Chow* and Sheng Biao Wan*. Optimization of Permethyl Ningalin B Analogues as P-glycoprotein Inhibitors. Bioorgan Med Chem, 2015, 23, 5566-73. Chao Yang, Iris L. K. Wong, Wen Bin Jin, Tao Jiang, Larry M. C. Chow* and Wan Sheng Biao*. Modification of Marine Natural Product Ningalin B and SAR Study Lead to Potent P-Glycoprotein Inhibitors. Marine Drugs.2014, 12, 209-5221. Jin Wen Bin,Wong Iris L. K., Hu Xue Shen, Zhang Xiao Yu, Li Fu Xing, Jiang Tao,Larry M. C. Chow* andWan Sheng Biao*. Structure-activity relationship study of permethyl ningalin B analogues as P-glycoprotein chemosensitizers. J Med Chem, 2013, 56, 9057-9070. Yuan Jian,Wong Iris L. K., Jiang Tao, Wang Si Wen, Liu Tao, Wen Bin Jin, Larry M. C. Chow* andWan Sheng Biao*. Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. Eur J Med Chem, 2012, 54, 413-422. Zhang Pu Yong, Wong Iris L. K., Yan,Clare S. W., Zhang Xiao Yu, Jiang Tao,Larry M. C. Chow* and Wan Sheng Biao*. Design and Syntheses of Permethyl Ningalin B Analogues: Potent Multidrug Resistance (MDR) Reversal Agents of Cancer Cells.J Med Chem, 2010, 53(14), 5108-5120. Yang Huan-Jie, Sun Dong-Kui, Chen Di, Cui Qiu-Zhi Cindy, Gu Yan-Yan, Jiang Tao, Chen Wei, Wan Sheng Biao*and Dou Q. Ping*. Antitumor activity of novel fluoro-substituted (-)-epigallocatechin-3-gallate analogs.Cancer Lett, 2010, 292(1), 48-53. Wan Sheng Biao, Yang Huan jie, Zhou Zhong yuan, Cui Qiu zhi Cindy, Chen Di, Kanwar Jyoti, Mohammad Imthiyaz, Dou Q. Ping, Chan Tak Hang*. Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors.Int J Mol Med, 2010,26(4), 447-455. Huo, C.; Wan, S. B.; Lam, W. H.; Li, L.; Wang, Z.; Landis-Piwowar, K. R.; Chen, D.; Dou, Q. P.; Chan, T. H. The challenge of developing green tea polyphenols as therapeutic agents. Inflammopharmacology (2008), 16(5), 248-252. Dou, Q. P.; Landis-Piwowar, K. R.; Chen, D.; Huo, C.; Wan, S. B.; Chan, T. H. Green tea polyphenols as a natural tumour cell proteasome inhibitor. Inflammopharmacology (2008), 16(5), 208-212. Yu, Zhiyong; Qin, Xu Long; Gu, Yan Yan; Chen, Di; Cui, Qiuzhi Cindy; Jiang, Tao; Wan, Sheng Biao; Dou, Q. Ping. Prodrugs of fluoro-substituted benzoates of EGC as tumor cellular proteasome inhibitors and apoptosis inducers. International Journal of Molecular Sciences (2008), 9(6), 951-961. Wan, Sheng Biao; Liu, Zhe Lin; Chen, Di; Dou, Qing Ping; Jiang, Tao. Polyphosphorous acid-catalyzed cyclization in the synthesis of cryptolepine derivatives. Chinese Chemical Letters (2007), 18(10), 1179-1181. Landis-Piwowar, Kristin R.; Wan, Sheng Biao; Wiegand, Richard A.; Kuhn, Deborah J.; Chan, Tak Hang; Dou, Q. Ping. Methylation suppresses the proteasome-inhibitory function of green tea polyphenols. Journal of Cellular Physiology (2007), 213(1), 252-260 Wan, Sheng Biao; Chen, Di; Dou, Q. Ping; Chan, Tak Hang. Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors. Bioorganic & Medicinal Chemistry (2004), 12(13), 3521-3527. Wan, Sheng Biao; Chan, Tak Hang. Enantioselective synthesis of afzelechin and epiafzelechin. Tetrahedron (2004), 60(37), 8207-8211. Wan, Sheng Biao; Landis-Piwowar, Kristin R.; Kuhn, Deborah J.; Chen, Di; Dou, Q. Ping; Chan, Tak Hang. Structure-activity study of epigallocatechin gallate (EGCG) analogs as proteasome inhibitors. Bioorganic & Medicinal Chemistry (2005), 13(6), 2177-2185. Wan, Sheng Biao; Dou, Q. Ping; Chan, Tak Hang. Regiospecific and enantioselective synthesis of methylated metabolites of tea catechins. Tetrahedron (2006), 62(25), 5897-5904.