个人简历

毛文君，博士、教授、博士生导师。2001–2003年在美国糖化学家Robert J Linhardt教授实验室从事硫酸多糖及其寡糖的结构与构效关系研究。主要从事海洋糖化学与糖药物研究开发。聚焦以海洋生物资源为主的新糖源发现、糖链结构和构效关系研究，从海藻和不同生境海洋微生物中发现了一批结构新颖、具有显著抗凝血、抗病毒、抗糖尿病及抗氧化活性的海洋多糖和寡糖。近年来完成了国家自然科学基金、国家科技支撑计划、国家重大创新药物专项、山东省科技发展计划和山东省自然科学基金等研究项目。在Bioresour Technol, Carbohydr Polym, Mar Biotechnol等国际权威杂志上发表论文60余篇，参编专著5部，获得国家发明专利3项，获国家技术发明一等奖、教育部高等学校科学技术发明一等奖、山东省科学技术进步二等奖（第1位）、山东省科学技术进步三等奖和青岛市科学技术进步二等奖（第1位）等多项科技奖励。

研究领域

针对心脑血管疾病等重大疾病，应用现代色谱分离、结构鉴定、活性筛选等技术，获得具有药用价值的海洋多糖及寡糖。主要包括：1. 海藻、海洋微生物及海洋动物中活性糖类化合物的提取分离和结构鉴定；2. 海洋多糖及寡糖的结构修饰和构效关系的研究；3. 海洋糖药物及功能制品的研究。

近期论文

1. Na Li, Xue Liu, Xiaoxi He, Shuyao Wang, Sujian Cao, Zheng Xia,Huali Xian, Ling Qin, Wenjun Mao*. Structure and anticoagulant property of a sulfated polysaccharide isolated from the green seaweed Monostroma angicava.Carbohydr Polym, 2017, 159, 195–206. (SCI, IF5.158) 2. Xue Liu, Jiejie Hao, Xiaoxi He, Shuyao Wang, Sujian Cao, Ling Qin, Wenjun Mao*. A rhamnan-type sulfated polysaccharide with novel structure from Monostroma angicava Kjellm (Chlorophyta) and its bioactivity.Carbohydr Polym, 2017, 173, 732–748. (SCI, IF 5.158) 3. Mengxia Yan,Wenjun Mao*, Xue Liu, Shuyao Wang, Zheng Xia, Sujian Cao, Jing Li, Ling Qin, Huali Xian. Extracellular polysaccharide with novel structure and antioxidant property produced by the deep-seafungus Aspergillus versicolor N2bc. Carbohydr Polym, 2016, 147, 272–281. (SCI, IF 4.811) 4. Yin Chen, Wenjun Mao*, Mengxia Yan, Xue Liu, Shuyao Wang, Zheng Xia, Bo Xiao, Sujian Cao, Baoqin Yang, Jie Li. Purification, chemical characterization, and bioactivity of an extracellular polysaccharide produced by the marine sponge endogenous fungus Alternaria sp. SP-32. Mar Biotechnol, 2016, 18(3), 301–313. (SCI, IF 3.062) 5.Na Li, Wenjun Mao*, Mengxia Yan, Xue Liu, Zheng Xia, Shuyao Wang, Bo Xiao, Chenglong Chen, Lifang Zhang, Sujian Cao. Structural characterization and anticoagulant activity of a sulfated polysaccharide from the green alga Codium divaricatum.Carbohydr Polym, 2015, 121, 175–182. (SCI, IF 4.219) 6. Yanli Chen, Wenjun Mao*, Hongwen Tao, Weiming Zhu, Mengxia Yan, Xue Liu, Tiantian Guo, Tao Guo. Preparation and characterization of a novel extracellular polysaccharide with antioxidant activity,from the mangrove-associated fungus Fusarium oxysporum.Mar Biotechnol, 2015, 17, 219–228.(SCI, IF 3.062) 7.Shoudong Guo, Wenjun Mao*, Mengxia Yan, Chunqi Zhao, Na Li, Jimiao Shan, Cong Lin, Xue Liu, Tao Guo, Tiantian Guo, Shuyao Wang. Galactomannan with novel structure produced by the coral endophytic fungus Aspergillus ochraceus. Carbohydr Polym,2014, 105, 325–333. (SCI, IF 4.074) 8. Mengxia Yan, Wenjun Mao*, Chenglong Chen, Xianglan Kong, Qianqun Gu, Na Li, Xue Liu, Baofeng Wang, Shuyao Wang, Bo Xiao. Structural elucidation of the exopolysaccharide produced by the mangrove fungus Penicillium solitum.Carbohydr Polym, 2014, 111, 485–491. (SCI, IF 4.074) 9. Yin Chen, Wenjun Mao*, Baofeng Wang, Lina Zhou, Qianqun Gu, Yanli Chen, Chunqi Zhao, Na Li, Chunyan Wang, Jimiao Shan, Mengxia Yan, Cong Lin. Preparation and characterization of an extracellular polysaccharide produced by the deep-sea fungus Penicillium griseofulvum. Bioresour Technol, 2013, 132, 178–181. (SCI, IF 5.039) 10. Yanli Chen, Wenjun Mao*, Junfeng Wang, Weiming Zhu, Chunqi Zhao, Na Li, Chunyan Wang, Mengxia Yan, Tao Guo, Xue Liu. Preparation and structural elucidation of a glucomannogalactan from marine fungus Penicillium commune.Carbohydr Polym, 2013, 97, 293–299. (SCI, IF 3.916) 11. Yin Chen, Wenjun Mao*, Yan Gao, Xiancun Teng, Weiming Zhu, Yanli Chen, Chunqi Zhao, Na Li, Chunyan Wang, Mengxia Yan, Jimiao Shan, Cong Lin, Tao Guo. Structural elucidation of an extracellular polysaccharide produced by the marine fungus Aspergillus versicolor.Carbohydr Polym, 2013, 93, 478–483. (SCI, IF 3.916) 12. Hongyan Li, Wenjun Mao*, Yujiao Hou, Yan Gao, Xiaohui Qi, Chunqi Zhao, Yin Chen, Yanli Chen, Na Li, Chunyan Wang. Preparation, structure and anticoagulant activity of a low molecular weight fraction produced by mild acid hydrolysis of sulfated rhamnan fromMonostroma latissimum. Bioresour Technol, 2012, 114, 414–418.(SCI, IF 4.750) 13. Yin Chen, Wenjun Mao*, Yupin Yang, Xiancun Teng, Weiming Zhu, Xiaohui Qi, Yanli Chen, Chunqi Zhao, Yujiao Hou, Chunyan Wang, Na Li. Structure and antioxidant activity of an extracellular polysaccharide from coral-associated fungus, Aspergillus versicolor LCJ-5-4. Carbohydr Polym, 2012, 87, 218–226. (SCI, IF 3.479) 14. Hongyan Li, Wenjun Mao*, Yin Chen, Sumei Ren, Xiaohui Qi, Yanli Chen, Chunqi Zhao,Na Li, Chunyan Wang, Cong Lin, Mengxia Yan, Jimiao Shan. Sequence analysis of the sulfated rhamno-oligosaccharides derived from a sulfated rhamnan. Carbohydr Polym,2012, 90, 1299–1304. (SCI, IF 3.479) 15. Xiaohui Qi, Wenjun Mao*, Yan Gao, Yin Chen, Yanli Chen, Chunqi Zhao, Na Li, Chunyan Wang. Mengxia Yan, Cong Lin, Jimiao Shan. Chemical characteristic of an anticoagulant-active sulfated polysaccharide fromEnteromorpha clathrata.Carbohydr Polym,2012, 90, 1804–1810. (SCI, IF 3.479) 16. Yin Chen, Wenjun Mao*, Hongwen Tao, Weiming Zhu, Xiaohui Qi, Yanli Chen, Hongyan Li, Chunqi Zhao, Yupin Yang, Yujiao Hou, Chunyan Wang, Na Li. Structural characterization and antioxidant properties of an exopolysaccharide produced by the mangrove endophytic fungus Aspergillus sp. Y16. Bioresour Technol, 2011, 102, 8179–8184. (SCI, IF 4.980) 17. Hongyan Li, Wenjun Mao*, Xiuli Zhang, Xiaohui Qi, Yin Chen, Yanli Chen, Jian Xu, Chunqi Zhao, Yujiao Hou, Yupin Yang, Na Li, Chunyan Wang. Structural characterization of an anticoagulant–active sulfated polysaccharide isolated from green alga Monostroma latissimum. Carbohydr Polym, 2011, 85, 394–400. (SCI, IF 3.628) 18. Haihong Sun, Wenjun Mao*, Jieying Jiao, Jiachao Xu,Hongyan Li, Yin Chen, Xiaohui Qi, Yanli Chen, Jian Xu, Chunqi Zhao, Yujiao Hou, Yupin Yang. Structural characterization of the extracellularpolysaccharides produced by the marine fungus Epicoccum nigrum JJY-40 and their antioxidant activities.Mar Biotechnol, 2011, 13, 1048–1055. (SCI, IF 3.430) 19. Shoudong Guo, Wenjun Mao*, Yin Han, Xiaohua Zhang, Chunli Yang, Yin Chen, Yanli Chen, Jian Xu, Hongyan Li, Xiaohui Qi, Jiachao Xu. Structural characteristics and antioxidant activities of the extracellular polysaccharides produced by marine bacterium Edwardsiella tarda. Bioresour Technol, 2010, 101, 4729–4732. (SCI, IF 4.365)