个人简历
李春霞，女，1975年02月生，博士，教授。教育部“新世纪优秀人才”计划资助获得者。2002年毕业于中国海洋大学获得博士学位，2002.07-至今在中国海洋大学医药学院工作，2008.09-2009.09年作为访问学者于美国佐治亚大学（University of Georgia）复杂碳水化合研究中心(Complex Carbohydrate Research Center)进行糖化学及糖生物学方面的研究。目前主要从事海洋糖类药物的研究与开发以及海洋先导化合物的结构优化。 近年来先后主持和参与完成国家自然科学基金、国家“863”计划、国家海洋局公益专项、国际合作交流项目及省市课题20余项。目前已发表文章70余篇，其中SCI收录论文40余篇，参与编写书籍1部；获得授权国家发明专利10余项。
研究领域
""1. 活性天然产物的合成及其构效关系的研究，尤其是天然活性寡糖及糖复合物的合成及其作为生物探针分子和候选治疗药物的研究\r2．海洋糖类药物及功能制品的研究与开发，以结构独特的海洋糖类为研究对象，构建海洋特征寡糖及其衍生物制备技术体系，研究海洋糖类化合物的构效关系规律，获得不同类型的寡糖功能制品及其寡糖药物。""""
近期论文
1.Yi-Ting Xue, Shuang Li, Wen-Jing Liu, Meng Xin, Hai-Hua Li, Guang-Li Yu, Hua-Shi Guan, Xiao-Xi He*, Chun-Xia Li*, The Mechanisms of Sulfated Polysaccharide Drug of Propylene Glycol Alginate Sodium Sulfate (PSS) on Bleeding Side Effect, Carbohydr. polymers, 2018, 195, 365-374 2.Meng Xin, Yang Sun, Haijiao Chen, Quancai Li, Yunlou Dun, Huashi Guan, Jiejie Hao*, Chun-Xia Li*, Propylene glycol guluronate sulfate (PGGS) reduces lipid accumulation via AMP-activated kinase activation in palmitate- induced HepG2 cells, Int. J. Biol. Macromol., 2018, 114(15): 26-34 3.Quancai Li, Yangyang Zeng, Linlin Wang, Huashi Guan, Chunxia Li*, Lijuan Zhang*,The heparin-like activities of negatively charged derivatives of low-molecular-weight polymannuronate and polyguluronate, Carbohydr. polymers, 2017, 155, 313-320 4.Yi-Ting Xue, Li Ren, Shuang Li, Lin-lin Wang, Xiao-Xi He, Xia Zhao, Guang-li Yu, Hua-Shi Guan, Chun-Xia Li*, Study on Quality Control of Sulfated Polysaccharide Drug, Propylene Glycol Alginate Sodium Sulfate (PSS), Carbohydr. polymers, 2016, 144, 330–337 5.Meng Xin, Li Ren, Yang Sun, Hai-hua Li, Hua-Shi Guan, Xiao-Xi He*, Chun-Xia Li*, Anticoagulant and antithrombotic activities of low-molecular-weight propylene glycol alginate sodium sulfate (PSS),Eur. J. Med. Chem, 2016, 114, 33-40 6.Jun Zhang, Chunxia Li*, Linlin Sun, Guangli Yu, Huashi Guan, Total synthesis of Myrmekioside A, a mono-O-alkyl diglycosylglycerol from marine sponge Myrmekioderma sp., Eur. J. Org. Chem.,2015, 19, 4246–4253 7.Cui Hao, Lixia Gao, Yiran Zhang, Wei Wang, Guangli Yu, Huashi Guan, Lijuan Zhang*, Chunxia Li*, Acetylated chitosan oligosaccharides act as antagonists against glutamate-induced PC12 cell death via Bcl-2/Bax signal pathway, Mar. Drugs,2015, 13, 1267-1289 8.Pengtao Zhang, Kun wang, Jun Zhang, Chunxia Li*, Huashi Guan, Total Synthesis of Sulfated Glycosphingolipid SM1a, A Kind of Human Epithelial Carcinoma Antigen, Eur. J. Org. Chem.,2015, 3, 570–583 9.Jun Zhang, Chunxia Li*, Guangli Yu and Huashi Guan, Total Synthesis and Structure-Activity Relationship of Glycoglycerolipids from Marine OrganismsMar. Drugs, 2014, 12, 3634-3659 10. Shan He, Jiejie Hao, Weibing Peng, Peiju Qiu, Chunxia Li*, Huashi Guan*, Modulation of lipid metabolism by Deep-sea Water in cultured human liver (HepG2) cells, Mar. Biotechnol., 2014, 16, 219-229 11. Peng-Li Li, Chun-Xia Li*, Yi-Ting Xue, Hai-Hua Li, Hong-Bing Liu, Xiao-Xi He, Guang-Li Yu and Hua-Shi Guan, An HPLC Method for Microanalysis and Pharmacokinetics of Marine Sulfated Polysaccharide PSS-Loaded Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles in Rat Plasma, Mar. Drugs, 2013, 11, 1113-1125 12. Quancai Li, Chunxia Li*, Cheng Yang, Chenchang Liu, Guangli Yu, Huashi Guan, Preparation,characterization and antioxidant activities of polymannuronic phosphate,H-phosphonate and sulfate, Int. J. Biol. Macromol., 2013, 62, 281-286 13. Jun Zhang, Yihua Sun, Chunxia Li*, Wei Wang, Xiaoshuang Zhang, Huashi Guan, Synthesis and antiviral evaluation of 6'-acylamido-6'-deoxy-α-D- mannoglycerolipids, Carbohydr. Res., 2013, 381,74-82 14. Chunxia Li*, Yihua Sun, Jun Zhang, Zhimin Zhao, Guangli Yu, Huashi Guan, Synthesis of 6'-acylamido-6'-deoxy-α-D-galactoglycerolipids, Carbohydr. Res., 2013, 376, 15-23 15. Yihua Sun, Jun Zhang, Chunxia Li*, Huashi Guan, Guangli Yu, Synthesis of glycoglycerolipid of 1,2-dipalmitoyl-3-(N-palmitoyl-6'-amino-6'-deoxy-a-D- glucosyl)-sn-glycerol and its analogues, inhibitors of human Myt1-kinase, Carbohydr. Res., 2012, 355, 6-12
