个人简历

1980年1月生，博士，教授，博士生导师，医药学院院长助理。教育部 “新世纪优秀人才支持计划”（2012）和“山东省自然科学杰出青年基金”获得者（2014），入选青岛海洋科学与技术国家实验室“鳌山人才”优秀青年学者（2015年）。被评为国家海洋局2015年度优秀科技青年（2015年）、获第九届青岛市青年科技奖（2013年）、山东省自然科学学术创新奖（2016年）。 2002年毕业于山东大学药学院，获学士学位；2002年至2007年于中国海洋大学医药学院硕博连读获药物化学博士学位（导师：顾谦群教授）；2007年7月至2009年7月在加拿大University of British Columbia进行海洋药物博士后研究（Raymond J Andersen课题组）。2009年9月经中国海洋大学“青年英才工程”人才引进加入医药学院天然药物化学研究室。2014年8月至2015年8月期间以访问学者身份赴美国加州大学洛杉矶分校（UCLA，Yi Tang课题组）从事真菌基因组采掘和合成生物学研究。

研究领域

""主要从事海洋天然药物化学研究。主要包括深远海、共附生等特殊海洋环境来源微生物功能基因和代谢产物的潜能挖掘、活性次级代谢产物发现、活性结构优化及构效关系研究。""""

近期论文

Liang Qiao, Zhongwei Duan, Xiaona Wu, Dehai Li*, Qianqun Gu, and Yankai Liu*. Organocatalytic Diversity-Oriented Asymmetric Synthesis of Structurally and Stereochemically Complex Heterocycles. Org. Lett. 2018, 20 (6), 1630–1633 \r
Wenqiang Guo#, Shuai Wang#, Na Li, Feng Li, Tianjiao Zhu, Qianqun Gu, Peng Guo* and Dehai Li*. Saroclides A and B, Cyclic Depsipeptides from the Mangrove-Derived Fungus Sarocladium kiliense HDN11-112. J. Nat. Prod. 81 (4), 1050–1054 (Most read articles) \r
Guangwei Wu#, Xin Qi#, Xiaomei Mo, Guihong Yu, Qiang Wang, Tianjiao Zhu, Qianqun Gu, Ming Liu*, Jing Li, and Dehai Li*. Structure-based Discovery of Cytotoxic Dimeric Tetrahydroxanthones as Potential Topoisomerase I Inhibitors from a Marine-derived Fungus. Eur. J. Med. Chem. 2018, 148, 268–278 \r
Feng Li, Zhenzhen Zhang, Guojian Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu and Dehai Li*. Determination of Taichunamide H and Structural Revision of Taichunamide A. Org. Lett. 2018, 20 (4), 1138–1141. \r
Guihong Yu, Yanjuan Wang, Rilei Yu, Yanyan Feng, Lu Wang, Qian Che, Qianqun Gu, Dehai Li, Jing Li and Tianjiao Zhu*. Chetracins E and F, cytotoxic epipolythiodioxopiperazines from the marine-derived fungus Acrostalagmus luteoalbus HDN13-530.RSC Adv. 2018, 8, 53-58. \r
Xueqian He#, Zhenzhen Zhang#, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li *. Varilactones and Wortmannilactones Produced by Penicillium variabile Cultured with Histone Deacetylase Inhibitor. Arch. Pharm. Res. 2018, 41, 57-63 \r
Feng Li#, Wenqiang Guo#, Li Wu, Tianjiao Zhu, Qianqun Gu, Dehai Li, Qian Che*. Saroclazines A-C, thio-diketopiperazines from mangrove-derived fungi Sarocladium kiliense HDN11-84. Arch. Pharm. Res. 2018, 41, 30-34 \r
Guihong Yu#, Shuai Wang#, Lu Wang, Qian Che, Tianjiao Zhu, Guojian Zhang, Qianqun Gu, Peng Guo*, and Dehai Li*. Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279. Mar. Drugs 2018, 16, 25-37; doi:10.3390/md16010025 \r
Zhenzhen Zhang, Xueqian He, Guojian Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Inducing Secondary Metabolite Production by Combined Culture of Talaromyces aculeatus and Penicillium variabile. J. Nat. Prod. 2017, 80 (12), 3167–3171 \r
Zhen Yang#, Meilin Zhu#, Dehai Li*, Rong Zeng*, Bingnan Han*. N-Me-trichodermamide B isolated from Penicillium janthinellum, with antioxidant properties through Nrf2-mediated signaling pathway. Bioorg. Med. Chem. 2017, 25(24), 6614-6622 \r
Fengli Yuan, Liang Qiao, Yinghan Chen, Xin Qi, Yankai Liu, Dehai Li, Qianqun Gu, Jing Li*, Ming Liu *. AS1041, a Novel Synthesized Derivative of Marine Natural Compound Aspergiolide A, Arrests Cell Cycle, Induces Apoptosis, and Inhibits ERK Activation in K562 Cells. Mar. Drugs2017, 15, 346; doi:10.3390/md15110346. \r
Meilin Zhu, Zhen Yang, Huimin Feng, Qi Gan, Qian Che, Tianjiao Zhu, Qianqun Gu, Bingnan Han* and Dehai Li*. Trichodermamides D–F, heterocyclic dipeptides with a highly functionalized 1,2-oxazadecaline core isolated from the endophytic fungus Penicillium janthinellum HDN13-309. RSC Adv., 2017, 7, 48019 – 48024. \r
Man-Cheng Tang#, Xiaoqing Cui#, Xueqian He, Zhuang Ding, Tianjiao Zhu, Yi Tang*, Dehai Li*. Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products. Org. Lett. 2017, 19 (19), 5376–5379 \r
Xiaoning Han, Zengzhi Liu, Zhenzhen Zhang, Xiaomin Zhang, Tianjiao Zhu, Qianqun Gu, Wenli Li, Qian Che*, and Dehai Li*. Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. J. Nat. Prod. 2017, 80 (5), 1684–1687 \r
Weiyi Zhang#, Qian Che#, Hongsheng Tan, Xin Qi, Jing Li, Dehai Li, Qianqun Gu, Tianjiao Zhu*, Ming Liu*. Marine Streptomyces sp. derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependent ubiquitin–proteasome system. Scientific Reports 2017, 7, 42180 \r
Meilin Zhu, Xiaomin Zhang, Huimin Feng, Jiajia Dai, Jing Li, Qian Che, Qianqun Gu, Tianjiao Zhu*, and Dehai Li*. Penicisulfuranols A–F, Alkaloids from the Mangrove Endophytic Fungus Penicillium janthinellum HDN13-309. J. Nat. Prod.2017, 80(1), 71-75. \r
Feng Li, Wenqiang Guo, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Versicones E-H and arugosin K produced by the mangrove-derived fungus Aspergillus versicolor HDN11-84. J Antibiot. 2017, 70, 174-178.