个人简历

2003.09-2006.07，中科院上海药物研究所，博士\r
2006.12-2010.05，科罗拉多大学医学健康中心，博士后\r
2010.05-2011.05，耶鲁大学药学系，博士后\r
2011.05-2012.10，耶鲁大学药学系，助理研究员\r
2012.10-至今，中国海洋大学海洋生命学院，教授，博士生导师

研究领域

""综合利用多组学技术，结构生物学及蛋白工程技术，开展海洋多糖降解酶及海洋生物粘附蛋白的发掘及应用基础研究。""""

近期论文

Zhuang J, Zhang K, Liu X, Liu W, Lyu Q*, Ji A*.Characterization of a novel PolyM-Preferred Alginate Lyase from Marine Vibrio splendidus OU02.Mar Drugs. 2018 Aug 22;16(9). pii: E295. doi: 10.3390/md16090295.\r
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Xiaokang Zhang1, Xiaoting Dai1, Lulu Wang, Yan Miao, Pingping Xu, Pengyu Liang, Bo Dong, Zhenmin Bao, Shi Wang, Qianqian Lyu*, Weizhi Liu*. Characterization of an atypical metalloproteinase inhibitors like protein(Sbp8-1) from scallop byssus. Front Physiol. 2018 May 23;9:597. doi: 10.3389/fphys.2018.00597. eCollection 2018.\r
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Lyu Q, Zhang K, Zhu Q, Li Z, Liu Y, Fitzek E, Yohe T, Zhao L, Li W, Liu T, Yin Y, Liu W*.Structural and biochemical characterization of a multidomain alginate lyase reveals a novel role of CBM32 in CAZymes.Biochim Biophys Acta-Gen Subjects. 2018 Jun 1;1862(9):1862-1869. \r
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Ren Y, Pan X, Lyu Q, Liu W*.Biochemical characterization of a fibrinolytic enzyme composed of multiple fragments.Acta Biochim Biophys Sin (Shanghai). 2018, 50(2):227-229.\r
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Lyu Q, Jiao W, Zhang K, Bao Z, Wang S, Liu W*. Proteomic analysis of scallophepatopancreatic extract providesinsights into marine polysaccharide digestion.Scientific Reports. 2016,16;6:34866. \r
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Lyu Q, Shi Y, Wang S, Yang Y, Han B, Liu W, Jones DN, Liu W *. Structural and biochemical insights into the degradation mechanism of chitosan by chitosanase OU01.Biochim Biophys Acta- Gen Subjects. 2015;1850(9):1953-1961. \r
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Miao Y, Zhang L, Sun Y, Jiao W, Li Y, Sun J, Wang Y, Wang S, Bao Z*, Liu W *. Integration of Transcriptomic and Proteomic Approaches Provides a Core Set of Genes for Understanding of Scallop Attachment.Mar Biotechnol (NY). 2015 :17(5):523-532 \r
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Fisher OS, Liu W, Zhang R, Stiegler AL, Ghedia S, Weber JL, Boggon TJ. Structural basis for the disruption of the Cerebral Cavernous Malformations 2 (CCM2) interaction with Krev Interaction Trapped 1 (KRIT1) by disease-associated mutations. J Biol Chem. 2015:290(5):2842-2853;\r
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Gifford SM§, Liu W§, Mader CC, Halo TL, Machida K, Boggon TJ, Koleske AJ. Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin. J Biol Chem.2014, 289(28):19704-19713\r
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Lyu Q, Wang S, Xu W, Han B, Liu W, Jones DN, Liu W. *.Structural insights into the substrate binding mechanism for a novel chitosanase. Biochemical Journal. (2014),461(2):335-345\r
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Liu W§,Draheim KM§, Zhang R, Calderwood DA, Boggon TJ.(§, coauthor) Mechanism for KRIT1 release of ICAP1-mediated integrin activation suppression. Molecular Cell.（2013）, 49(4 ):719-729.（Highlighted by Nature Structural & Molecular Biology, (2013,20:143) (IF:12.2).\r
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Liu, W.,Jankowska-Anyszka, M., Piecyk, K., Dickson, L., Wallace, A., Niedzwiecka, A., Stepinski, J., Stolarski, R., Darzynkiewicz, E., Kieft, J., Zhao, R., Jones, D.N.M., and R.E. Davis. Structural Basis for nematode eIF4E binding an m2,2,7G-cap and its implications for translation initiation.Nucleic Acids Research 2011，39(20):8820-8832.\r