个人简历
刘延凯，博士，副教授，于2010 年7 月在四川大学获博士学位，师从陈应春教授（杰青）。主要研究方向：手性有机小分子催化的不对称合成反应研究及手性药物合成。2009年，以交换生的身份在德国科隆大学，Prof. A. Berkessel研究小组，进行了为期5个月的手性不对称催化研究。2011年，获得了欧盟最著名的奖学金Marie Curie fellowship（玛丽居里奖学金），在西班牙Institute of Chemical Research of Catalonia (ICIQ) 研究所，Prof. P. Melchiorre指导下进行博士后研究工作，主要研究药物的有机及仿生合成。在过去几年的工作中，主要对卡宾、手性双功能硫脲及手性胺类催化剂催化的反应进行了深入的研究，相关研究结果在包括Angew. Chem. Int. Ed.，J. Am. Chem. Soc.和Org. Lett.等高水平国际期刊上发表了20多篇SCI文章，有多篇研究论文分别被SYNFACTS和Science杂志专题报道并作为亮点介绍，有1篇研究论文工作被Organic Chemistry Portal收录并专题推介。多次参加国内及国际学术会议并发表多篇会议论文，合作出版2篇专著章节。教育背景： 2010.04-2013.04 Institut Català d'Investigació Química（ICIQ研究所，西班牙），博士后研究，指导老师：Prof. Dr. P. Melchiorre 2009.09-2009.12 University of Cologne（科隆大学，德国），有机化学学院，交换生，指导老师：Prof. Dr. A. Berkessel 2006.09-2010.07 四川大学，华西药学院，博士研究生，指导老师：陈应春教授 2004.09-2006.07 四川大学，华西药学院，硕士研究生，指导老师：陈应春教授 1998.09-2002.07 山东大学，药学院，本科 工作经历： 2002.07-2004.08 横店集团成都分子实验室有限公司，主要负责研发医药化工中间体。 2012.12-2013.09 西南交通大学，生命科学与工程学院，药物合成，副教授。 2013.09- 中国海洋大学，医药学院，药物合成，副教授。
研究领域
药物设计与合成，主要研究内容包括： 1. 手性海洋活性天然产物含吲哚类化合物的设计与合成 2. 多取代手性海洋活性天然产物含氮及杂环化合物的设计与合成 3. 多取代手性海洋活性天然产物含羰基化合物及其衍生物的设计与合成
近期论文
Xue-Jiao Lv, Ying-Han Chen, and Yan-Kai Liu*, “Two Competitive but Switchable Organocatalytic Cascade Reaction Pathways: The Diversified Synthesis of Chiral Acetal-Containing Bridged Cyclic Compounds”, Org. Lett. 2019, 21, 190. Liang Qiao, Zhong-Wei Duan, Ying-Han Chen, Ye-Peng Luan, Qian-Qun Gu, Yan-Kai Liu*, and De-Hai Li*, “Aspergiolides A and B: Core Structural Establishment and Synthesis of Structural Analogues”, J. Org. Chem. 2019, 84, 4451. Chao-Chao Xie, Rui Tan, and Yan-Kai Liu*, “Asymmetric construction of polycyclic indole derivatives with different ring connectivities by an organocatalysis triggered two-step sequence”, Org. Chem. Front. 2019, 6, 919. Ying-Han Chen, De-Hai Li,* and Yan-Kai Liu*, “Diversified Synthesis of Chiral Chromane-Containing Polyheterocyclic Compounds via Asymmetric Organocatalytic Cascade Reactions”, ACS Omega 2018, 3, 16615. Xiao-Na Wu, Zhi-Hao You, and Yan-Kai Liu*, “Different hybridized oxygen atoms controlled chemoselective formation of oxocarbenium ions: synthesis of chiral heterocyclic compounds”, Org. Biomol. Chem. 2018, 16, 6507. Zhi-Hao You, Ying-Han Chen, Yu Tang, and Yan-Kai Liu*, “Organocatalytic Asymmetric Synthesis of Spiro-Bridged and Spiro-Fused Heterocyclic Compounds Containing Chromane, Indole, and Oxindole Moieties”, Org. Lett. 2018, 20, 6682. Liang Qiao, Zhong-Wei Duan, Xiao-Na Wu, De-Hai Li,* Qian-Qun Gu, and Yan-Kai Liu*, “Organocatalytic Diversity-Oriented Asymmetric Synthesis of Structurally and Stereochemically Complex Heterocycles”, Org. Lett.2018, 20, 1630. Jun-Ping Pei, Ying-Han Chen, and Yan-Kai Liu*, “Asymmetric Organocatalytic Sequential Reaction of Structurally Complex Cyclic Hemiacetals and Functionalized Nitro-olefins To Synthesize Diverse Heterocycles”, Org. Lett.2018, 20, 3609. Zhi-Hao You, Ying-Han Chen, Xiao-Na Wu, and Yan-Kai Liu*, “Lactols in Asymmetric Sequential Organo- and Gold-Catalysis: Synthesis of Densely Functionalized Epimeric Bicyclic O,O-Acetals”, Adv. Syn. Catal.2017, 359, 4260. Chao Liu and Yan-Kai Liu*, “Asymmetric Organocatalytic One-Pot, Two-Step Sequential Process to Synthesize Chiral Acetal-Containing Polycyclic Derivatives from Cyclic Hemiacetals and Enones”, J. Org. Chem.2017, 82, 10450. Wei-Wei Zhao and Yan-Kai Liu*, “Enantio- and diastereoselective synthesis of tetrahydrofuro[2,3-b]furan-2(3H)-one derivatives and related oxygen heterocycles via an asymmetric organocatalytic cascade process”, Org. Chem. Front.,2017, 4, 2358. Ying-Han Chen, Xue-Li Sun, Hua-Shi Guan and Yan-Kai Liu*, “Diversity-Oriented One-Pot Synthesis to Construct Functionalized Chroman-2-one Derivatives and Other Heterocyclic Compounds”, J. Org. Chem.2017, 82, 4774. Ji-Yao Li, Ke-Wei Yu, Chao-Chao Xie and Yan-Kai Liu*, “Lactols in an asymmetric aldol-desymmetrization sequence: access to tetrahydro-4H-furo[2,3-b] pyran-2-one and tetrahydro-4H-furo[2,3-b] furan-2-one derivatives”, Org. Biomol. Chem., 2017, 15, 1407. Zhi-Hao You, Ying-Han Chen and Yan-Kai Liu*, “From racemic precursors to fully stereocontrolled products: one-pot synthesis of chiral α-amino lactones and lactams”, Org. Biomol. Chem., 2016, 14, 6316. Pin-Wen Cai, Zhi-Hao You, Liang-Hui Xie, Rui Tan*, Zhi-Ping Tong* and Yan-Kai Liu*, “The Attractive Application of Lactol Chemistry: From Racemic Lactol to Natural Product Skeleton”, Synthesis,2016, 48, 2581. Zhi-Long Li, Chao Liu, Rui Tan, Zhi-Ping Tong, and Yan-Kai Liu*, “Organocatalytic, Asymmetric [2+2+2] Annulation to Construct Six-Membered Spirocyclic Oxindoles with Six Continuous Stereogenic Centers”, Catalysts2016, 6, 65. Ji-Yao Li, Zhi-Long Li, Wei-Wei Zhao, Zhi-Ping Tong, Yan-Kai Liu*, Rui Tan, “One-pot, highly efficient, asymmetric synthesis of ring-fused piperidine derivatives bearing N,O- or N,N-acetal moieties”, Org. Biomol. Chem., 2016, 14, 2444. Xue-Li Sun, Ying-Han Chen, Dan-Yang Zhu, Yan Zhang, Yan-Kai Liu*, “Substrate-Controlled, One-Pot Synthesis: Access to Chiral Chroman-2-one and Polycyclic Derivatives”, Org. Lett., 2016, 18, 864. Huan-Xi Feng, Rui Tan, Yan-Kai Liu* “An Efficient One-Pot Approach to the Construction of Chiral Nitrogen-Containing Heterocycles under Mild Conditions”, Org. Lett., 2015, 17, 3794. Yan-Kai Liu*, Zhi-Long Li, Ji-Yao Li, Huan-Xi Fen, “Open−Close: An Alternative Strategy to α‑Functionalization of Lactone via Enamine Catalysis in One Pot under Mild Conditions”, Org. Lett., 2015, 17, 2022.
