个人简历

顾谦群，女，硕士，教授，博士生导师。现任中国药学会海洋药物专业委员会委员、中国微生物学会海洋微生物学专业委员会委员、《中国海洋药物》、《中国抗生素杂志》杂志编委。 1992年于日本东北大学获药学硕士。

研究领域

主要从事海洋天然产物化学和海洋创新药物的研究。近年来从海洋微生物中发现活性新化合物500余个，其中2个结构新颖的先导化合物已进入候选药物研究阶段。

近期论文

1. Qian Che, Tianjiao Zhu, Xin Qi, Attila Mándi, Tibor Kurtán, Xiaomei Mo, Jing Li, Qianqun Gu, and Dehai Li*. Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp. CHQ-64. Org. Lett. 2012, http://dx.doi.org/10.1021/ol301396h, (IF = 5.250) 2. Liyuan Li, Dehai Li, Yepeng Luan, Qianqun Gu and Tianjiao Zhu*.Cytotoxic metabolites from the antarctic psychrophilic fungus Oidiodendron truncatum. J. Nat. Prod. 2012, 75(5): 920-927. (IF = 2.872) 3. Li Chen, Tianjiao Zhu, Yuanqing Ding, Ikhlas A. Khan*, Qianqun Gu, and Dehai Li*. Sorbiterrin A, a novel sorbicillin derivative with cholinesterase inhibition activity from the marine-derived fungus Penicillium terrestre. Tetrahedron. Lett.. 2012, 53: 325-328. (IF = 2.618) 4. Shengxin Cai, Xianglan Kong, Wei Wang, Huinan Zhou, Tianjiao Zhu, Dehai Li*, Qianqun Gu*. Aspergilazine A, a Diketopiperazine Dimer with a Rare N-1 to C-6 Linkage, from a Marine-derived Fungus Aspergillus taichungensis. Tetrahedron. Lett.. 2012, 53 (21): 2615-2617. (IF = 2.618) 5. Jixing Peng, Jieying Jiao, Jing Li, Wei Wang, Qianqun Gu, Tianjiao Zhu*, Dehai Li*. Pyronepolyene C-glucosides with NF-κB inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40. Bioorg. Med. Chem. Lett., 2012, 22(9): 3188-3190 (IF = 2.661) 6. Lin Du, Hongchun Liu, Wei Fu, Dehai Li, Qiuming Pan, Tianjiao Zhu, Meiyu Geng*, and Qianqun Gu*. Unprecedented citrinin trimer tricitinol B functions as a novel topoisomerase Iiα inhibitor. J. Med. Chem. 2011, 54, 5796-5810 (IF = 5.207) 7. Lin Du, Jing Ai, Dehai Li, Tianjiao Zhu, Ying Wang, Michael Knauer, Torsten Bruhn, Hongbing Liu, Meiyu Geng,* Qianqun Gu,* and Gerhard Bringmann*, Aspergiolides C and D, Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects, Chem. A. Euro. J, 2011, 17(4), 1319-1326. (IF = 5.476) 8. Guojian Zhang, Shiwei Sun, Tianjiao Zhu, Zhenjian Lin, Jingyan Gu, Dehai Li* and Qianqun Gu*. Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum. Phytochemistry. 2011. 72, 1436-1442.( IF =3.150) 9. Shengxin Cai, Tianjiao Zhu, Lin Du, Boyu Zhao, Dehai Li* and Qianqun Gu*. Sterigmatocystins from the deep-sea-derived fungus Aspergillus versicolor. J. Antibiot. 2011, 64,193-196 (IF = 1.628). 10. Shengxin Cai, Shiwei Sun, Huinan Zhou, Xianglan Kong, Tianjiao Zhu, Dehai Li*, and Qianqun Gu*. Prenylated polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07. J. Nat. Prod. 2011, 74(5): 1106-1110 (IF = 2.872) 11. Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao, Qianqun Gu*. A Alkaloids from a deep ocean sediment derived fungus Penicillium sp. and their antitumor activities, J. Antibiot. 2010, 63, 165-170 (IF = 1.628) 12. Dehai Li, Shengxin Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao, Qianqun Gu*. Three new sorbicillin trimers, trisorbicillinones B, C and D, from a deep ocean sediment derived fungus, Phialocephala sp. FL30r, Tetrahedron, 2010, 66, 5101-5106 (IF = 3.219) 13. Lin Du, Dehai Li, Guojian Zhang, Tianjiao Zhu, Jing Ai, Qianqun Gu*, Novel Carbon-Bridged Citrinin Dimers from a Volcano Ash-Derived Fungus Penicillium citrinum and their cytotoxic and cell-cycle arrest activities, Tetrahedron, 2010, 66, 9286-9290 (IF = 3.219). 14. Lin Du, Dehai Li, Tianjiao Zhu, Shengxin Cai, Fengping Wang, Xiang Xiao, and Qianqun Gu*. New alkaloids and diterpenes from a deep ocean sediment derived fungus Penicillium sp.. Tetrahedron, 2009, 65 (5) 1033-1039 (IF = 3.219) 15. Kejing Tao, Lin Du, Xueqian Sun, Menghao Cai, Tianjiao Zhu, Xiangshan Zhou, Qianqun Gu, and Yuanxing Zhang. Biosynthesis of aspergiolide A, a novel antitumor compound by a marine-derived fungus Aspergillus glaucus via the polyketide pathway. Tetrahedron Lett., 2009, 50 (9):1082–1085 (IF = 2.66) 16. Zhenjian Lin, Tianjiao Zhu, and Qianqun Gu*. Spicochalasin A and New Aspochalasins from the Marine-Dirived Fungus Spicaria elegans. Eur. J. Org. Chem., 2009, 18, 3045-3051. (IF = 3.096) 17. Li Chen, Yuchun Fang, Tianjiao Zhu, Qianqun Gu, * Weiming Zhu, * Nine New Gentisyl Alcohol Derivatives from the Marine-Derived Fungus Penicillium terrestre. J. Nat. Prod. 2008, 71 (1) 66–70 (IF = 2.843) 18. Fazuo Wang, Yuchun Fang, Min Zhang, Aiqun Lin, Tianjiao Zhu, Qianqun Gu*, Weiming Zhu*, Six New Ergosterols from the Marine-derived Fungus Rhizopus sp., Steroids, 2008, 73 (1): 19-26 (IF = 2.588). 19. Zhenjian Lin, Tianjiao Zhu, Yuchun Fang, Qianqun Gu*, Weiming Zhu*, Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum, Phytochemistry. 2008, 69 (5) 1273–1278. (IF = 2.946). 20. Rui Liu, Zhenjian Lin, Tianjiao Zhu, Yuchun Fang, Qianqun Gu* Weiming Zhu*, Novel Open-chain Cytochalsins from the Marine-derived Fungus Spicaria elegans，J. Nat. Prod. 2008, 71(7):1127-1132(IF = 2.843). 21. Fazuo Wang, Yuchun Fang, Tianjiao Zhu, Min Zhang, Aiqun Lin, Qianqun Gu,* and Weiming Zhu*, Seven New Prenylated Indole Diketopiperazine Alkaloids from Holothurian-derived Fungus Aspergillus fumigatus, Tetrahedron, 2008, 64 (34): 7986-7991(IF = 2.897).