个人简历

主要从事化学与酶法定向合成海洋来源糖类化合物和糖胺聚糖类寡糖，开发新颖的糖聚合物合成方法并应用于活性多糖模拟物的制备，特征糖类化合物的活性评价及糖类药物研发工作。近年来在Chem. Rev., Nat. Chem. Biol., ACS Macro Lett., Biomacromolecules等杂志发表SCI论文50余篇。主持国家自然科学基金、山东省重点研发计划以及参与国家重点研发计划、国家重大新药创制等多项国家及省部级课题。\r
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教育背景\r
2007.09~2011.01\t中国科学院生态环境研究中心 环境科学 博士\r
2004.09~2007.06\t山东大学化学院 有机化学\t硕士\r
2000.09~2004.06\t山东大学环境科学与工程学院 环境工程 学士\r
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工作经历\t\r
2014.12~今 中国海洋大学 医药学院\t副教授\r
2011.01~2014.12\t美国伦斯勒理工学院 博士后/研究助理\r
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学术兼职\t\r
《Current Organic Chemistry》编委 \r
《合成化学》编委\r
中国药学会会员\r
中国化学会会员\r
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承担课程\r
有机化学（本科生课程）\r
糖工程与糖药物学（研究生课程）

研究领域

""主要从事海洋来源糖类化合物和糖胺聚糖的化学酶法合成研究。""""

近期论文

Jianghua Li#, Yang Zhang#, Chao Cai#*, Xiaozhi Rong, Meng Shao, Jiarui Li, Chendong Yang, Guangli Yu*. Collaborative assembly of doxorubicin and galactosyl diblock glycopolymer for targeted delivery of hepatocellular carcinoma. Biomater. Sci., 2020, 8, 189–200.\r
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Jia Li, Feifei Gu, Chao Cai*, Minghua Hu, Luodi Fan, Jiejie Hao*, Guangli Yu*. Purification, structural characterization, and immunomodulatory activity of the polysaccharides from Ganoderma lucidum. Int. J. Biol. Macromol., 2020, 143，806-813.\r
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Xueliang Wang, Zimei Yang, Xu Xu, Hao Jiang*, Chao Cai*, Guangli Yu*. Odd-numbered agaro-oligosaccharides alleviate type 2 diabetes mellitus and related colonic microbiota dysbiosis in mice. Carbohyd. Polym., 2020, 240, 116261.\r
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Jun Li, Chao Cai*, Lihao Wang, Chendong Yang, Hao Jiang, Miaomiao Li, Ding Xu, Guoyun Li, Chunxia Li, Guangli Yu*. Chemoenzymatic synthesis of heparan sulfate mimetic glycopolymers and their interactions with the receptor for advanced glycation end-product. ACS Macro Lett., 2019, 8, 1570-1574.\r
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Fei Fan, Ping Zhang, Lihao Wang, Tiantian Sun, Chao Cai*, Guangli Yu*. Synthesis and properties of functional glycomimetics through click grafting of fucose onto chondroitin sulfates. Biomacromolecules, 2019, 20, 3798-3808.\r
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Jun Li, Jiarui Li, Tiantian Sun, Chao Cai*, Meng Shao, Guangli Yu*. Concise chemoenzymatic synthesis of heparan sulfate analogues as potent BACE-1 inhibitors. Carbohyd. Polym., 2019, 217, 232-239.\r
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Jun Li, Chao Cai*, Chendong Yang, Jianghua Li, Tiantian Sun, Guangli Yu. Recent advances in pharmaceutical potential of brown algal polysaccharides and their derivatives. Curr. Pharm. Design, 2019, 25, 1290-1311.\r
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Jia Li, Chao Cai*, Mengmeng Zheng, Jiejie Hao, Ya Wang, Minghua Hu, Luodi Fan, Guangli Yu*. Alkaline extraction, structural characterization, and bioactivities of (1→6)-β-d-glucan from Lentinus edodes. Molecules, 2019, 24, 1610.\r
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Brady F. Cress, Ujjwal Bhaskar, Deepika Vaidyanathan, Asher Williams, Chao Cai, Xinyue Liu, Li Fu, Vandhana M-Chari, Fuming Zhang, Shaker A. Mousa, Jonathan S. Dordick, Mattheos A. G. Koffas, Robert J. Linhardt*. Heavy heparin: a stable isotope‐enriched, chemoenzymatically‐synthesized, poly‐component drug. Angew. Chem. Int. Ed., 2019, 58, 5962 –5966.\r
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Fei Fan, Chao Cai*, Wei Wang, Lei Gao, Jun Li, Jia Li, Feifei Gu, Tiantian Sun, Jianghua Li, Chunxia Li, and Guangli Yu*. Synthesis of fucoidan-mimetic glycopolymers with well-defined sulfation patterns via emulsion ring-opening metathesis polymerization. ACS Macro Lett., 2018, 7, 330-335.\r
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Lihao Wang, Fei Fan, Haotian Wu, Lei Gao, Ping Zhang, Tiantian Sun, Chendong Yang, Guangli Yu, Chao Cai*. Effect of anomeric configuration on stereocontrolled α-glycosylation of L-Fucose. Synlett, 2018, 29, 2701-2706.\r
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Jianghua Li, Chao Cai*, Jiarui Li, Jun Li, Jia Li, Tiantian Sun, Lihao Wang, Haotian Wu, Guangli Yu. Chitosan-based nanomaterials for drug delivery. Molecules, 2018, 23, 2661.\r
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Fei Fan, Chao Cai*, Lei Gao, Jun Li, Ping Zhang, Guoyun Li, Chunxia Li, and Guangli Yu*. Microwave-assisted synthesis of glycopolymers by ring-opening metathesis polymerization (ROMP) in an emulsion system. Polym. Chem., 2017, 8, 6709-6719.\r
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Lang Ding, Xindi Shan, Xiaoliang Zhao, Hualian Zha, Xiaoyu Chen, Jianjun Wang, Chao Cai*, Xiaojiang Wang, Guoyun Li, Jiejie Hao, Guangli Yu*. Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata polysaccharide for wound healing applications. Carbohydr. Polym., 2017, 157, 1538-1547.\r
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Angeles Farrán, Chao Cai, Manuel Sandoval, Yongmei Xu, Jian Liu, María J. Hernáiz*, and Robert J. Linhardt*. Green solvents in carbohydrate chemistry: from raw materials to fine chemicals. Chem. Rev., 2015, 115, 6811-6853.\r
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Sashka Dimitrievska, Chao Cai, Amanda Weyers, Jenna L. Balestrini, Tylee Lin, Sumati Sundaram, Go Hatachi, David A. Spiegel, Themis R. Kyriakides, Jianjun Miao, Guoyun Li, Laura E. Niklason, Robert J. Linhardt*. Click-coated, heparinized, decellularized vascular grafts. Acta Biomater., 2015, 13, 177-187.\r
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Chao Cai, Demetria M. Dickinson, Lingyun Li, Sayaka Masuko, Matt Suflita, Victor Schultz, Shawn D. Nelson, Ujjwal Bhaskar, Jian Liu & Robert J. Linhardt*. Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides. Org. Lett., 2014, 16, 2240-2243.\r
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Yongmei Xu, Chao Cai, Kasemsiri Chandarajoti, Po-Hung Hsieh, Lingyun Li, Truong Q. Pham, Erica M. Sparkenbaugh, Juzheng Sheng, Nigel S. Key, Rafal Pawlinski, Edward N. Harris, Robert J. Linhardt* and Jian Liu*. Homogeneous low-molecular-weight heparins with reversible anticoagulant activity. Nat. Chem. Biol., 2014, 10, 248-250.\r
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Chao Cai, Lingyun Li, Cate Harvey, Jian Liu, Robert J. Linhardt*. Towards the chemoenzymatic synthesis of heparan sulfate oligosaccharides: Oxidative cleavage of p-nitrophenyl group with ceric ammonium salts. Tetrahedron Lett., 2013, 54, 4471-4474.\r
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Chao Cai, Kristi Edgar, Jian Liu, Robert J. Linhardt*. Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides. Carbohyd. Res., 2013, 372, 30-34.\r
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Chao Cai, Kemal Solakyildirim, Bo Yang, Julie M. Beaudet, Amanda Weyers, Robert J. Linhardt, Fuming Zhang*. Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A. Carbohyd. Polym., 2011, 87, 822-829.\r
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Chao Cai, Jun Liu, Yuguo Du* and Robert J. Linhardt. Stereoselective total synthesis of (−)-Cleistenolide. J. Org. Chem., 2010, 75, 5754-5756. \r
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出版著作\t\r
1.Chao Cai, Jun Li, Fei Fan, Guoyun Li, Chunxia Li, Guangli Yu. Synthesis of marine polysaccharides/oligosaccharides and their derivatives (Chapter 12), Royal Society of Chemistry, 2019, Wanyi Guan, Lei Li, Peng George Wang, Synthetic Glycomes.\r
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专利\r
已授权\r
1.蔡超，于广利，凡飞，李国云. 聚降冰片烯骨架糖聚合物的制备方法及其在岩藻聚糖硫酸酯模拟物合成中的应用，2020.03.27. 中国，201810126793.X.\r
2.于广利, 张晓, 李国云, 蔡超, 李芹英. 一种低抗凝肝素、其低聚糖及其制备方法和在制备抗阿尔兹海默症的药物中的应用, 2017.11.01, 中国, 201510933082.X.\r
3.李国云, 李芹英, 于广利, 蔡超, 郝杰杰, 蒋昊. 一种岩藻糖化硫酸软骨素FCShm及其制备方法和应用, 2019.12.05, 中国, 201710564187.1.\r
4.于广利, 赵小亮, 李国云, 蔡超. 一种透明质酸奇数寡糖单体及其制备方法, 2018.04.03, 中国, 201510921459.X.\r
5.于广利, 李芹英, 李国云, 尚庆森, 赵小亮, 蔡超, 郝杰杰. 一种高硫酸化硫酸角质素及其制备方法和应用, 2019.09.03, 中国, 201611102103.4.