个人简历
教育经历（按时间倒排序）：2004/09–2007/07，中国科学院海洋研究所，海洋生物专业，博士2001/09–2004/07，中国海洋大学，海洋资源与环境专业，硕士1997/09–2001/06，中国海洋大学，渔业资源专业，学士工作经历（科研与学术工作经历，按时间倒排序）：2016/12–现在，中国海洋大学，水产学院，教授2011/10–2016/11，中国海洋大学，水产学院，副教授2010/05–2011/05，美国加州大学尔湾分校，客座研究助理员2009/09–2009/12，中国科学院海洋研究所，海洋生态与环境科学重点实验室，助理研究员2007/11–2009/08，美国南卡罗莱纳大学，博士后授课经历主讲本科生《生物化学》，研究生和留学生《鱼类行为学》承担课题1、国家自然科学基金面上项目、miRNA靶向调控刺参响应高温低氧逆境胁迫的分子机制研究、2020/01月-2023/12、主持。2、国家自然科学基金面上项目、刺参夏眠相关神经肽发掘及其功能验证、2017/01月-2020/12、主持。3、国家自然科学基金面上项目、DNA甲基化对刺参夏眠调控关键基因的转录抑制机理、2015/01月-2018/12、主持。4、国家自然科学基金青年基金项目、夏眠刺参代谢减退相关microRNAs发掘及其调控作用研究、2013/01-2015/12、主持。5、教育部新教师基金项目、夏眠刺参代谢减退相关microRNAs的发掘及其表达分析、2013/01-2015/12、主持。6、山东省自然科学基金项目、热刺激诱导扇贝细胞凋亡MAPKs信号途径的研究、2012/07-2015/07、主持。7、中国海洋大学英才工程人才项目、2012/01-2013/12、主持。
研究领域
棘皮动物分子生理学""
近期论文
1.YujiaYang,YingqiuZheng,LinaSunandMuyanChen*(2020).Genome-WideDNAMethylationSignaturesofSeaCucumberApostichopusjaponicusduringEnvironmentalInducedAestivation.Genes,11,1020.doi:10.3390/genes11091020.（通讯作者）2.ShashaWang,YingqiuZheng,MuyanChen*,KennethBStorey(2020).UltrastructuralvariationandkeyERchaperonesresponseinducedbyheatstressinintestinalcellsofseacucumberApostichopusjaponicus.JournalofOceanologyandLimnology,https://doi.org/10.1007/s00343-020-9265-8.（通讯作者）3.MuyanChen,AlzbetaTalarovicova,YingqiuZheng,KennethB.Storey,ElphickMaurice(2019).NeuropeptideprecursorsandneuropeptidesintheseacucumberApostichopusjaponicus:agenomic,transcriptomicandproteomicanalysis.ScientificReports,9:8829.（通讯作者）4.ShanshanWang,MuyanChen*,YingchaoYin,KennethB.Storey(2019).MiR-200-3pIsPotentiallyInvolvedinCellCycleArrestbyRegulatingCyclinAduringAestivationinApostichopusjaponicus.Cells,8(8),843.（通讯作者）5.LiLi,ChenMuyan*,KennethB.Storey(2019).MetabolicresponseoflongitudinalmusclestoacutehypoxiainseacucumberApostichopusjaponicus(Selenka):ametabolomeintegratedanalysis.ComparativeBiochemistryandPhysiology,PartD,29,235-244.（通讯作者）6.RiseMatthewL,MartyniukChristopherJ,ChenMuyan(2019).Comparativephysiologyandaquaculture:TowardOmics-enabledimprovementofaquaticanimalhealthandsustainableproduction.Comparativebiochemistryandphysiology.PartD,Genomics&proteomics,100603.7.YihangWang,ShanshanZhou,TianyuLiu,MuyanChen,WentaoLi,XiumeiZhang(2019).Thetranscriptomicresponsesofthearkshell,anadarabroughtonii,tosulfideandhypoxiaexposure.MolecularBiologyReports,46:4245–4257.8.MuyanChen*,ShanshanWang,XingkeLi,KennethB.Storey,XiumeiZhang(2018).ThepotentialcontributionofmiRNA-200-3ptothefattyacidmetabolismbyregulatingAjEHHADHduringaestivationinseacucumber.PeerJ6:e5703https://doi.org/10.7717/peerj.5703(通讯作者)9.ShashaWang,XingkeLi,MuyanChen*,KennethB.Storey,TianmingWang(2018).Apotentialantiapoptoticregulation:Theinteractionofheatshockprotein70andapoptosis-inducingfactormitochondrialduringheatstressandaestivationinseacucumber.JournalofExperimentalZoology-A,329,103–111.(通讯作者)10.QiWang,XiumeiZhang,MuyanChen,WentaoLi,PeidongZhang(2018).Comparisonofintestinalmicrobiotaandactivitiesofdigestiveandimmune-relatedenzymesofseacucumberApostichopusjaponicusintwohabitats.JournalofOceanologyandLimnology,36(3),990–1001.11.SongNa,MuyanChen,TianxiangGao,YANAGIMOTOTakashi(2017).ProfileofcandidatemicrosatellitemarkersinSebastiscusmarmoratususing454pyrosequencing.ChineseJournalofOceanologyandLimnology,35(1):198-202.（并列第一作者）12.MuyanChen*,AijunZhu,KennethB.Storey(2016).Comparativephosphoproteomicanalysisofintestinalphosphorylatedproteinsinactiveversusaestivatingseacucumbers.JournalofProteomics,135,141-150.(通讯作者)13.AijunZhu,MuyanChen*,XiumeiZhang,KennethB.Storey(2016).Genestructure,expression,andDNAmethylationcharacteristicsofseacucumbercyclinBgeneduringaestivation.Gene,594,82-88.(通讯作者)14.XiaoweiXiang,MuyanChen,ChangwenWu,AiyiZhu,JingwenYang,ZhenmingLv,TianmingWang(2016).GlycolyticregulationinaestivationoftheseacucumberApostichopusjaponicus:evidencefrommetabolitequantificationandrate-limitingenzymeanalyses.MarineBiology,163(8),167.15.MuyanChen*,XingkeLi,AijunZhu,KennethB.Storey,LinaSun,TianxiangGao,TianmingWang(2016).UnderstandingmechanismofseacucumberApostichopusjaponicusaestivation:InsightsfromTMT-basedproteomicstudy.ComparativeBiochemistryandPhysiology,D,19,78-89.(通讯作者)16.YeZhao,MuyanChen*,KennethB.Storey,LinaSun,HongshengYang*(2015).DNAmethylationlevelsanalysisinfourtissuesofseacucumberApostichopusjaponicusbasedonfluorescence-labeledmethylation-sensitiveamplifiedpolymorphism(F-MSAP)duringaestivation.CompBiochemPhysiol,PartB,doi:10.1016/j.cbpb.2014.11.001.（通讯作者）17.MuyanChen*,FangyuWang,KunXing,AijunZhu*,ShanshanZhang*(2015).Chapter15–immunologyanddiseases.DevelopmentsinAquaculture&FisheriesScience,39,257-287.18.YeZhao,HongshengYang*,KennethB.Storey,MuyanChen*(2014).DifferentialgeneexpressionintherespiratorytreeoftheseacucumberApostichopusjaponicusduringaestivation.Mar.Genomics,18,173-183,doi:10.1016/j.margen.2014.07.001.（通讯作者）19.DeyouMa,HongshengYang,LinaSun,MuyanChen(2014).TranscriptionprofilingusingRNA-SeqdemonstratesexpressiondifferencesinthebodywallsofjuvenilealbinoandnormalseacucumbersApostichopusjaponicus.ChineseJournalofOceanologyandLimnology,2014,32(01):34-46.20.MuyanChen*,KennethB.Storey(2014).Large-scaleidentificationandcomparativeanalysisofmiRNAexpressionprofileintherespiratorytreeoftheseacucumberApostichopusjaponicusduringaestivation.Mar.Genomics,13,39-44.（通讯作者）21.YeZhao,HongshengYang*,KennethB.Storey,MuyanChen*(2014).RNA-SeqdependenttranscriptionalanalysisunveilsgeneexpressionprofileintheintestineofseacucumberApostichopusjaponicusduringaestivation.CompBiochemPhysiol,PartD,10,30-43.（通讯作者）22.YeZhao,MuyanChen#,TianmingWang,LinaSun,DongxueXu,HongshengYang(2014).SelectionofreferencegenesforqRT-PCRanalysisofgeneexpressioninseacucumberApostichopusjaponicusduringaestivation.ChineseJournalofOceanologyandLimnology,32,1248-1256.（共同第一作者）23.YeZhao,MuyanChen*,LinSu,TianmingWang,ShilinLiu,HongshengYang*(2013).Molecularcloningandexpression-profileanalysisofseacucumberDNA(Cytosine-5)-methyltransferase1andmethyl-CpGbindingdomaintype2/3genesduringaestivation.CompBiochemPhysiol,PartB,165(1):26-35.（通讯作者）24.LinaSun,HongshengYang*,MuyanChen*,DeyouMa,ChenggangLin(2013).RNA-SeqRevealsDynamicChangesofGeneExpressioninKeyStagesofIntestineRegenerationintheSeaCucumberApostichopusjaponicus.PLoSONE,8(8):e69441.（通讯作者）25.MuyanChen*,XiumeiZhang,JianningLiu,KennethB.Storey(2013).High-throughputsequencingrevealsdifferentialexpressionofmiRNAsinintestinefromseacucumberduringaestivation.PLoSONE,8,e76120.（通讯作者）26.LinaSun,HongshengYang*,MuyanChen*,DongxueXu(2013).ThecloningandexpressionanalysisofWnt6andHox6duringintestineregenerationintheseacucumberApostichopusjaponicus.GenetMolRes,12(4):5321-5334.（通讯作者）27.KirilLHristov,MuyanChen，RupalP.Soder，ShankarP.Parajuli,QiupingCheng,WhitneyF.Kellett,GeorgiV.Petkov*(2012).KV2.1andelectricallysilentKVchannelsubunitscontrolexcitabilityandcontractilityofguineapigdetrusorsmoothmuscle.AmJPhysiolCellPhysiol,302,C360-C372.28.KirilL.Hristov*,MuyanChen*,SergeA.Y.Afeli,QiupingCheng,EricS.Rovner,GeorgiV.Petkov1(2012).ExpressionandfunctionofKV2-containingchannelsinhumanurinarybladdersmoothmuscle.AmericanJournalofPhysiology-CellPhysiology,302(11),C1599–C1608.（并列第一作者）29.KirilHristov,MuyanChen,SergeAfeli,Columbia,SC,EricRovner,Charleston,SC,GeorgiPetkov*,Columbia,SC(2011).223Expressionandfunctionofvoltage-gatedK+channelssensitivetostromatoxin-1inhumandetrusorsmoothmuscle.TheJournalofUrology,185(4),e91.30.HuanZhao,HongshengYang,HelingZhao,MuyanChen,ShilinLiu(2011).Heatstress-mediatedgeneexpressioninthebodywallofthejapaneseseacucumberApostichopusjaponicus.Aquaticbiology,12(1),23-31.31.LinaSun,MuyanChen*,HongshengYang*,TianmingWang,BaozhongLiu,CynthiaShu,DavidM.Gardiner(2011).LargeScaleGeneExpressionProfilingduringIntestineandBodyWallRegenerationintheSeaCucumberApostichopusjaponicus.CompBiochemPhysiol,PartD,6,195-205.（通讯作者）32.KirilLHristov,MuyanChen，WhitneyF.Kellett,EricS.Rovner，GeorgiV.Petkov*(2011).Large-conductancevoltage-andCa2+-activatedK+channelsregulatehumandetrusorsmoothmusclefunction.AmJPhysiolCellPhysiol,301,C903-C912.33.TianmingWang,HongshengYang,HuanZhao,MuyanChen,BingWang(2011).Transcriptionalchangesinepigeneticmodifiersassociatedwithgenesilencingintheintestineoftheseacucumber,Apostichopusjaponicus(Selenka),duringaestivation.ChineseJournalofOceanologyandLimnology,29(6),1267–1274.34.HuanZhao,HongshengYang*，HelingZhao,MuyanChen,TianmingWang(2011).Themolecularcharacterizationandexpressionofheatshockprotein90(Hsp90)and26(Hsp26)cDNAsinseacucumber(Apostichopusjaponicus).CellStressChaperones,16,481-493.35.MuyanChen,WhitneyF.Kellett,GeorgiV.Petkov*(2010).Voltage-gatedK+channelssensitivetostromatoxin-1regulatemyogenicandneurogeniccontractionsofraturinarybladdersmoothmuscle.AmJPhysiol-Regulatory,IntegrativeandComparativePhysiology.299,177-184.36.MuyanChen,HongshengYang,BiaoXu,FangyuWang,BaozhongLiu(2010).Catecholaminergicresponsestoenvironmentalstressinthehemolymphofzhikongscallopchlamysfarreri.JournalofExperimentalZoologyPartAEcologicalGenetics&Physiology,309A(6),289-296.37.MuyanChen,GeorgiV.Petkov*(2009).IdentificationofLargeConductanceCalciumActivatedPotassiumChannelAccessoryβ4SubunitinRatandMouseBladderSmoothMuscle.TheJournalofUrology,182(1),374–381.38.BiaoXu,MuyanChen,HongshengYang,SanjunZhao(2008).Starvation-inducedChangesofHemocyteParametersintheZhikongScallopChlamysfarreri.JournalofShellfishResearch,27(5),1195–1200.39.MuyanChen,HongshengYang⁎,MaryseDelaportec,SanjunZhao(2007).ImmuneconditionofChlamysfarreriinresponsetoacutetemperaturechallenge.Aquaculture,271(1-4),479–487.40.MuyanChen,HongshengYang⁎,MaryseDelaporte,SanjunZhao,KunXing(2007).ImmuneresponsesofthescallopChlamysfarreriafterairexposuretodifferenttemperatures.JournalofExperimentalMarineBiologyandEcology,345(1),52–60.41.MuyanChen,XiumeiZhang,TianxiangGao,ChaoChen(2006).Effectsoftemperature,pHandNaClonproteaseactivityindigestivetractofyoungturbot,Scophthalmusmaximus.ChineseJournalofOceanologyandLimnology,24(3),300–306.
