个人简历

教育和工作经历
2018.07-至今扬州大学生物科学与技术学院讲师
2013.09-2018.06浙江大学化学工程与生物工程学院生物化工专业工学博士
2009.09-2013.06浙江工业大学生物工程学院生物工程专业工学学士
主持科研项目
扬州大学高层次人才科研启动基金（2018-）
2019年江苏省“双创计划”双创博士（2020-2022）
教学任务
微生物学全英文教学

研究领域

1.天然产物的微生物合成与智能制造
2.蛋白质的分子改造
3.高密度发酵工艺优化"授权及申请专利：
1.于洪巍，周萍萍，叶丽丹.β-胡萝卜素酮化酶突变体、重组表达载体、基因工程菌及其应用授权号：ZL201610903201.1
2.于洪巍，周萍萍，叶丽丹.Gal4温敏型突变体、重组表达载体、温度调控系统及其应用，公布号：CN107987138A"

近期论文

1.PingpingZhou;MinLi;Binshen;ZhenYao;QiBiao;LidanYe(*);HongweiYu.DirectedCoevolutionofβ-CaroteneKetolaseandHydroxylaseandItsApplicationinTemperature-RegulatedBiosynthesisofAstaxanthin.JAgrFoodChem,2019,67(4):1072-1080.(一区)
2.PingpingZhou,WenpingXie,ZhenYao,YongqiangZhu,LidanYe*andHongweiYu.Developmentofatemperature-responsiveyeastcellfactoryusingengineeredGal4asaproteinswitch.BiotechnolBioeng,2018,115:1321-1330.(二区)
3.PingpingZhou,WenpingXie,AipengLi,FanWang,ZhenYao,QiBian,YongqiangZhu,HongweiYuandLidanYe*.AlleviationofmetabolicbottleneckbycombinatorialengineeringenhancedastaxanthinsynthesisinSaccharomycescerevisiae.EnzymeMicrobiolTechnol,2017,100:28-36.(三区)
4.PingpingZhou,LidanYe,WenpingXie,XiaomeiLvandHongweiYu*.HighlyefficientbiosynthesisofastaxanthininSaccharomycescerevisiaebyintegrationandtuningofalgalcrtZandbkt.ApplMicrobiolBiotechnol2015,99：8419-8428(二区)
5.ZhenYao,PingpingZhou,BingmeiSu,SisiSu,LidanYe*,andHongweiYu*EnhancedIsopreneProductionbyReconstructionofMetabolicBalancebetweenStrengthenedPrecursorSupplyandImprovedIsopreneSynthaseinSaccharomycescerevisiae.AcsSyntheticBiology,2018:7(9),2308–2316.(二区)
6.FanWang,XiaomeiLv,WenpingXie,PingpingZhou,YongqiangZhu,ZhenYao,ChenchenYang,XiaohongYang,LidanYe*andHongweiYu*.Combininggal4p-mediatedexpressionenhancementanddirectedevolutionofisoprenesynthasetoimproveisopreneproductioninSaccharomycescerevisiae.MetabEng,2017,39:257-266.(一区)
7.XiaomeiLv,FanWang,PingpingZhou,LidanYe,WenpingXie,HaomingXuandHongweiYu*.Dualregulationofcytoplasmicandmitochondrialacetyl-CoAutilizationforimprovedisopreneproductioninSaccharomycescerevisiae.NatCommun,20167,12851.(一区)
8.WenpingXie,XiaomeiLv,LidanYe,PingpingZhouandHongweiYu*.Constructionoflycopene-overproducingSaccharomycescerevisiaebycombiningdirectedevolutionandmetabolicengineering.MetabEng,2015,30:69-78.(一区)
9.LidanYe,WenpingXie,PingpingZhouandHongweiYu*.Biotechnologicalproductionofastaxanthinthroughmetabolicengineeringofyeasts.ChemBioEngReviews,2015,2(2),107-117(2015).
10.周萍萍，叶丽丹，于洪巍.合成生物学中动态代谢途径调控策略的研究进展.生物产业技术,2019,1:55-61