个人简历

学习经历
1980-1984本科江苏农学院兽医
1984-1987硕士研究生江苏农学院传染病与預防兽医
1987-1990博士研究生南京农业大学传染病与預防兽医
工作简历
2014.10-现在扬州大学兽医学院扬州大学特聘教授
2013-2014Rush大学医学院解剖与细胞生物学系副教授
2008-2014芝加哥Rush大学医学院外料学系副教授
2000-2007芝加哥Rush大学医学院外科学系助理教授
1997-1999芝加哥Rush大学医学院外科学系讲师
1993-1996芝加哥Rush大学医学院外科学系ResearchAssociate
1991-1992芝加哥Rush大学医学院免疫与微生物学系博士后

研究领域

本实验室以细胞信号通路为基础，研究宿主细胞内信号通路中的关键性的酶以及转录因子在抗感染免疫中的作用以及在人与动物重要疾病中的致病作用和机理。主要研究包括预防兽医学和医学两方面，前者主要研究流感病毒、猪流行性腹泻病毒以及沙门氏菌感染宿主细胞后病原蛋白造成宿主细胞损伤的机理以及宿主细胞抗病原感染的分子机制，研究针对宿主细胞中参与病原复制増殖的关键性的酶抑制剂作为抗病原感染以及免疫调控的药物；医学方面，主要研究细胞内表达失调或由于基因突变过度激活或失活的关键性的酶或转录因子在肿瘤和糠尿病以及一些神经退行性疾病中的作用以及这些酶抑制剂的药物开发研究。"目前在研项目：
1.国家自然科学基金面上项目：Shh信号通路调控甲状腺肿瘤干细胞自我更新的机理与应用研究；
主持，58万，O1/2O17T2/2O2O
2.江苏省双创团队：重要畜篱传染病的防制；参与，90万，01/2016-12/2018"

近期论文

1.Liu,W,Jiang,Y,Sun,J,Geng,S,Pan,Z,Prinz,R.A,Wang,C,Sun,J.Jiao,X,Xu,X.Xu,X*.(2018)ActivationofTGF-beta-activatedkinase1(TAK1)restrictsSalmonellaTyphimuriumgrowthbyinducingAMPKactivationandautophagy,CellDeathDisease,Inpress
2.Sun,J,Mu,Y,Jiang,Y,Song,R,Yi,J,Zhou,J,Sun,J,Jiao,x,Prinz,RA,Li,Y,Xu,x*.(2018)Inhibitionofp70S6kinaseactivitybyA771726inducesautophagyandenhancesthedegradationofsuperoxidedismutase1(soD1)proteinaggregates,CellDeathDisease,DOIVol.9,DOI101038/s41419-018-0441-0
3.ChenJ,SunJ,DoscasME:YeJ,WilliamsonA,LiY,LiY,PrinRA,XuX*.(2018)Controlofhyperglycemiainmalemicebyleflunomide:mechanismsofaction.J.Endocrinol.237(1):43-58.
4.Xu,X*,Lu,Y,Li,Y,Prinz,R.(2017)SonichedgehogsignalinginthyroidcancerFrontiersinEndocrinol.DOI103389/fend2017.00284
5.Xu,x*,Sun,J,Song,R,Doscas,M.E.,Williamson,A.J.,Zhou,J,Sun,J.Jiao,X,Liu,X,Li,Y.(2017)Inhibitionofp70S6kinase(S6K1)activitybyA771726,theactivemetaboliteofleflunomide,inducesautophagythroughTAK1-mediatedAMPKandJNKactivation.OncotargetPublishedonlinedoi:10.18632/oncotarget.16737
6.Xux*,RaoG,andLiY.(2016).Xanthineoxidoreductaseisrequiredforgenotoxicligandexpressionandgemcitabine-mediatedantitumoractivity.Oncotarget.7:59220-59235
7.WilliamsonAT,DoscasME,YeJ,HeidenKB,XingM,LiY,PrinzRA,andXuX*(2016)ThesonichedgehogsignalingpathwaystimulatesanaplasticthyroidcancercellmotilityandinvasivenessbyactivatingAktandc-Met.Oncotarget.7:10472-85
8.Doscas,M.E,willianson,A,Usha,L,Bogachkov,Y,Rao,G.S.,Xiao,F,Wang,W,Ruby,C,Kaufman,H,Zhou,Z,Williams,J.W,Li,Y,Xu,X*.(2014)Inhibitionofp70s6kinase(S6K1)activitybyA771726anditseffectoncellproliferationandcellcycleprogress.Neoplasia16(10):824-34.
9.Heiden,K.B,Williamson,A.J,Doscas,M.E,Ye,J,Wang,Y,Prinz,R.A,Xu,x*.(2014)Thesonichedgehogsignalingpathwaymaintainsanaplasticthyroidcancerstemcellself-renewalbyinducingSnailexpression.J.ClinicalEndo.Metab.99(11):E2178-87
10.Xu,X*,Ding,HG,Rao,G.Arora,S,Gattuso,P,Solorzano,C,Prinz,RA.(2012)WidespreadexpressiontheSonicHedgehogpathwaymoleculesinthyroidtumorsanditsroleincellproliferation.Endocrine-RelatedCancer.19:167-179
11.Rao,G,Ding,HG,Huang,W,Maxhimer,JB,Lewis,EJ,Reddy,v.,Prinz,RA.,xu,X*,(2011)Highglucoseinducesheparanase.proteoglycandegradationintheendothelialcellsbyreactiveoxygenspeciesproduction:Apotentialroleindiabetes-relatedatherosclerosis.Diabetologia,54:1527-1538
12.WiinhovenT,vandenHoven,Ding,H,Kuppervelt,T.H.,vandenVlog,J,Berden,T,Lewis,E.J.,Schwartz,M,andXu,x*(2008)Heparanaseinducesadifferentiallossofheparansulfatedomainsinovertdiabeticnephropathy.Diabetologia51:372-382
13.Xu,X*,Rao,G,Quiros,R.Q.,Kim,A.W.,Brunn,G.J.,Platt,J.L.Gattuso,PPrinz,RA.(2007)Invivoandinvitrodegradationofheparansulfate(HS)proteoglycansbyheparanase-1(HPR1)inpancreaticadenocarcinomas:LossofcellsurfaceHSsuppressesFGF2-mediatedcellsignalingandproliferation.J.Biol.Chem282:2363-2373
14.Xu,x*,Rao,R,Gaffud,MJ,Ding,HG,Maki,G,Klingemann,H.G,Groh,V,Spies,T,Caillat-Zucman,S,Gattuso,P,Plate,J.Prinz,R.A.(2006)clinicopathologicsignificanceofmajorhistocompatibilitycomplexclassI-relatedchainAandB(MICA/B)expressioninthyroidcancer.J.clin.Endo.Metab.91:2704-2712
15.Maxhimer,J.B,Somenek,M,Rao,G,CatherineE.Pesce,C.E,Baldwin,D.Jr,Gattuso,P,Schwartz,M.M,Lewis,E.J,Prinz,R.AandXu,X*.(2005)Heparanase-1geneexpressionandregulationbyhighglucoseinrenalepithelialcells:apotentialroleinthepathogenesisofproteinuriaindiabeticpatients.Diabetes54:2172-2178
16.Xu,X'Quiros,R.L,Shen,I,Gattuso,P,Ain,K.B.,Prinz,R.A.(2003)HighprevalenceofBRAFgenemutationinpapillarythyroidcarcinomasandthyroidtumorcelllines.CancerRes.63:4561-4561
17.Xu,x*,Quiros,R.M,JustinB.Maxhimer,J.B,Jiang,J.Marcinek,R,AinK.B,Platt,J.L,Shen,J
Gattuso,P.Prinz,R.A.(2003)Inversecorrelationbetweenheparansulfatedepositionandheparanase-1geneexpressioninthyroidpapillarycarcinomas:apotentialroleintumormetastasis.Clin.CancerRes9:59686979
18.Jiang,P,Kumar,A,Parrillo,J.E,Dempsey,L.A,Platt,J.L.,Prinz,R.A,andXu,x*.(2002)Cloningandcharacterizationofthehumanheparanase1(HPR1)genepromoter:RoleofGA-bindingprotein(GABP)andSplinregulatingHPR1basalpromoteractivity.JBiolChem,277:8989-8998
19.Li,X.,A.S.-F.Chong,J.Wu,K.Roebock,A.Kunar,R.Kimberbly,U.R.Rapp,Jw.Williams,andX,Xu*(1999)TranscriptionalregulationofFasgeneexpressionbyGA-bindingprotein(GABP)andAP-1transcriptionfactorsinTcellantigenreceptor/CD3-activatedTcells.].Biol.Chem.274:35203-35210
20.u,X*,X-Y,Fu,J.Plate,andA.S.-F.Chong.1998)IFN-inducescellgrowthinh1bitionbyFas-mediatedapoptosis:RequirementofSTATIproteinforup-regulationofFasandFasL.CancerRes.58:2832-2837Xu,x*,williams,J.wShen,J,Gong,H,Yin,D,Blinder,L.Elder,R.T,Sankary,H,Finnegan,A.andChong,A.S-F.(1998)Invitroandinvivomechanismsofactionoftheanti-proliferativeandimmunosuppressiveagent,brequinarsodium.Immuno160:846-853.
21.Xu,X*,H.Gong,J.Shen,A.Finnegan,J.W.Williams,andA.S.-F.Chong.(1997)InvivomechanismbywhichleflunomidecontrolslymphoproliferativeandautoimmunediseaseinMRL-lpr/lprmice.J.Immunol.159:167-174
22.Xu,X.andA.S-F.Chong(1995)Cross-linkingofCD45onNKcellsstimulatesp56lck-mediatedtyrosinephosphorylationandIFN-production.Immuno155:5241-5248