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耿拓宇
2023-05-16 09:39
  • 耿拓宇
  • 耿拓宇 - 研究员 硕导-扬州大学-动物科学与技术学院-个人资料

近期热点

资料介绍

个人简历


学习与工作简历
1985.09—1989.07江苏农学院学士
1989.09—1992.07江苏农学院硕士
1992.08—2002.08江苏省家禽科学研究所实习研究员、助理研究员、副研究员
2002.08—2005.07VirginiaTech访问学者、研究助理
2005.08—2007.05VirginiaTech博士
2007.06—2008.12DukeUniversity博士后
2009.01—2009.12UniversityofVirginia博士后
2010.01—2013.04MedicalUniversityofSouthCarolina博士后
2013.04—2017.06扬州大学动物科学与技术学院副研究员
2017.07—至今扬州大学动物科学与技术学院研究员

研究领域


研究曾涉及动物遗传育种学和人类医学。目前的研究兴趣包括:
1)家禽遗传育种;
2)非酒精性脂肪肝形成机理的研究;
3)家禽经济性状的分子基础与关键基因的功能研究"近期科研项目
(1)国家自然科学基金面上项目“鹅肥肝形成过程中内质网应激作用的研究”(31472086)

近期论文


(1)HuX,ChenS,JiaC,XueS,DouC,DaiZ,XuH,SunZ,GengT,CuiH.(2018)Geneexpressionprofileandlongnon-codingRNAanalysis,usingRNA-Seq,inchickenembryonicfibroblastcellsinfectedbyavianleukosisvirus.J.ArchVirol.IF=2.3.
(2)LiuY,HanX,YuanJ,GengT,ChenS,HuX,CuiIH,CuiH.(2017)BiallelicInsertionofaTranscriptionalTerminatorviaCRISPR/Cas9EfficientlySilencesExpressionofProtein-codingandNon-codingRNAGenes.JBiolChem.292(14):5624-5633.IF=4.3.
(3)LongLiu,YanfengFan,ZhenheZhang,YangChan,TuoyuGeng,DaoqingGong,ZhuochengHou,ZhonghuaNing.(2017)AnalysisofgeneexpressionandregulationimplicatesC2H9orf152hasanimportantroleincalciummetabolismandchickenreproduction.AnimalReproductionScience.176:1-10.IF=1.4.
(4)HuX,ZhuW,ChenS,LiuY,SunZ,GengT,SongC,GaoB,WangX,QinA,CuiH.(2017)ExpressionpatternsofendogenousavianretrovirusALVE1anditsresponsetoinfectionwithexogenousaviantumourviruses.ArchVirol.162(1):89-101.IF=2.3.
(5)GengT#*,ZhaoX*,XiaL,LiuL,LiF,YangB,WangQ,MontgomeryS,CuiH,GongD#.(2016)Supplementingdietarysugarpromotesendoplasmicreticulumstress-independentinsulinresistanceandfattyliveringoose.BiochemBiophysResCommun.476(4):665-9.IF=2.4,#Correspondingauthor(s).*Equalcontribution.
(6)GengT#*,YangB*,LiF,XiaL,WangQ,ZhaoX,GongD.#(2016)Identificationofprotectivecomponentsthatpreventtheexacerbationofgoosefattyliver:Characterization,expressionandregulationofadiponectinreceptors.CompBiochemPhysiolBBiochemMolBiol.194-195:32-8.IF=1.7,#Correspondingauthor(s).*Equalcontribution.
(7)LiuL,ZhaoX,WangQ,SunX,XiaL,WangQ,YangB,ZhangY,MontgomeryS,MengH,GengT#,GongD#.(2016)ProsteatoticandProtectiveComponentsinaUniqueModelofFattyLiver:GutMicrobiotaandSuppressedComplementSystem.SciRep.6:31763.IF=5.2,#Correspondingauthor(s).
(8)OsmanRH,LiuL,XiaL,ZhaoX,WangQ,SunX,ZhangY,YangB,ZhengY,GongD#,GengT#.(2016)Fads1and2arepromotedtomeetinstantneedforlong-chainpolyunsaturatedfattyacidsingoosefattyliver.MolCellBiochem.418(1-2):103-17.IF=2.6,#Correspondingauthor(s).
(9)ZhaoJ,YaoJ,LiF,YangZ,SunZ,QuL,WangK,SuY,ZhangA,MontgomerySA,GengT#,CuiH#.(2016)Identificationofcandidategenesforchickenearly-andlate-feathering.PoultSci.95(7):1498-503.IF=1.7,#Correspondingauthor(s).
(10)OsmanR.H.,D.Shao,L.Liu,L.Xia,X.Sun,Y.Zheng,L.Wang,R.Zhang,Y.Zhang,J.Zhang,D.Gong#,T.Geng#.(2016).Expressionofmitochondria-relatedgenesiselevatedinoverfeeding-inducedgoosefattyliver.ComparativeBiochemistryandPhysiologyB-Biochemistry&MolecularBiology.192:30-7.IF=1.6,#Correspondingauthor(s).
(11)HuX,ZhuW,ChenS,LiuY,SunZ,GengT,WangX,GaoB,SongC,QinA,CuiH.(2016)ExpressionoftheenvgenefromtheavianendogenousretrovirusALVEandregulationbymiR-155.ArchVirol.161(6):1623-32.IF=2.3.
(12)SutterA.G.,A.P.Palanisamy,J.H.Lench,S.Esckilsen,T.Geng,D.N.Lewin,L.A.Cowart,K.D.Chavin.(2016)DietarySaturatedFatPromotesDevelopmentofHepaticInflammationthroughToll-LikeReceptor4inMice.JournalofCellularBiochemistry.117(7):1613-21.IF=3.3
(13)ShihaoChen,XumingHu,WenqiZhu,ChongxinJia,XiaoHan,JuntingYuan,ZhenSun,ZheYang,TuoyuGeng,HengmiCui.(2016)Reactivationofdevelopment-relatedgenesbytheDNAmethylation1inhibitorAza-2’-deoxycytidineinchickenembryofibroblasts.PoultSci.96(4):1007–1014.IF=1.7.
(14)GengT.*,A.Sutter*,M.D.Harland,B.A.Law,J.S.Ross,D.Lewin,A.Palanisamy,S.B.Russo,K.D.Chavin,L.A.Cowart.(2015)SphK1mediateshepaticinflammationinamousemodelofnonalcoholicsteatohepatitisinducedbyhighsaturatedfatfeedingandinitiatesproinflammatorysignalinginhepatocytes.JournalofLipidResearch.56(12):2359-71.IF=4.4,*Equalcontribution.
(15)GengT.#*,L.Xia*,F.Li,J.Xia,Y.Zhang,Q.Wang,B.Yang,S.Montgomery,H.Cui,D.Gong#.(2015)Theroleofendoplasmicreticulumstressandinsulinresistanceintheoccurrenceofgoosefattyliver.BiochemicalandBiophysicalResearchCommunications.465:83-7.IF=2.3,#Correspondingauthor(s).*Equalcontribution.
(16)GengT.#,L.Xia,S.Russo,D.Kamara,L.A.Cowart.(2015)Prosteatoticgenesareassociatedwithunsaturatedfatsuppressionofsaturatedfat-inducedhepaticsteatosisinC57BL/6mice.NutritionResearch.35:812-22.IF=2.5.#Correspondingauthor(s).
(17)GengT.#,X.GuanX,E.J.Smith.(2015)Screeningforgenesinvolvedinantibodyresponsetosheepredbloodcellsinthechicken,Gallusgallus.PoultryScience.94:2099-107.IF=1.7,#Correspondingauthor(s).
(18)CuiL.L.,J.F.Wang,K.Z.Xie,A.H.Li,T.Y.Geng,L.R.Sun,J.Y.Liu,M.Zhao,G.X.Zhang,G.J.Dai,J.Y.Wang.(2015)Analysisofmeatflavorcompoundsinpedigreeandtwo-strainYangzhougeese.PoultryScience.94:2266-71.IF=1.7
(19)GuanX.,P.Silva,K.Gyenai,J.Xu,T.Geng,E.Smith.(2015)MitochondrialDNA-BasedAnalysesofRelatednessAmongTurkeys,Meleagrisgallopavo.BiochemicalGenetics.53:29-41.IF=0.9
(20)GengT.,W.Hu,M.H.Broadwater,J.M.Snider,J.Bielawski,S.B.Russo,J.H.Schwacke,J.Ross,L.A.Cowart.(2013)Fattyacidsdifferentiallyregulateinsulinresistancethroughendoplasm-reticulum-stress-mediatedinductionoftribbleshomologue3:apotentiallinkbetweendietaryfatcompositionandthepathophysioloigcaloutcomesofobesity.Diabetologia.56:2078-87.IF=6.9
(21)Russo,B.S.,C.F.Baicu,AnVanLaer,T.Geng,H.Kasiganesan,M.R.Zile,andL.A.Cowart.(2012).CeramideSynthase5mediateslipid-inducedautophagyandhypotrophyincardiomyocytes.JournalofClinicalInvestigation.122:3919-30.IF=12.8
(22)HuW.,J.Ross,T.Geng,S.E.Brice,andL.A.Cowart.(2011)Differentialregulationofdihydroceramidedesaturasebypalmitatevs.monounsaturatedfattyacids:Implicationstoinsulinresistance.JournalofBiologicalChemistry.286:16596-605.IF=4.8
(23)Geng,T.,P.Li,X.Yin,andZ.Yan.(2011).PGC-1αpromotesnitricoxide-antioxidantdefensesandinhibitsFOXOsignalingagainstcardiaccachexiainmice.AmericanJournalofPathology.178(4):1738-48.IF=4.9
(24)ZechnerC.,L.Lai,J.L.Fong,T.Geng,Z.Yan,J.W.Rumsey,D.Collia,Z.Chen,D.F.Wozniak,T.C.Leone,andD.P.Kelly.(2010).TotalSkeletalMusclePGC-1DeficiencyUncouplesMitochondrialDerangementsfromFiberTypeDeterminationandInsulinSensitivity.CellMetabolism.12(6):633-42.IF=18.2
(25)GengT.*,P.Li*,M.Okutsu,X.Yin,J.Kwek,M.Zhang,andZ.Yan.(2010).PGC-1αplaysafunctionalroleinexercise-inducedmitochondrialbiogenesisandangiogenesisbutnotfiber-typetransformationinmouseskeletalmuscle.AmericanJournalofPhysiology-HeartandCirculatoryPhysiology.298(3):C572-579.*Equalcontribution.IF=3.8
(26)PogozelskiA.R.,T.Geng,P.Li,X.Yin,V.A.Lira,M.Zhang,J.T.Chi,andZ.Yan.(2009).p38gammamitogen-activatedproteinkinaseisakeyregulatorinskeletalmusclemetabolicadaptationinmice.PLoSOne.4(11).IF=4.4
(27)GuanX.,P.Silva,K.B.Gyenai,J.Xu,T.Geng,Z.Tu,D.C.Samuels,andE.J.Smith.(2009).TheMitochondrialGenomeSequenceandMolecularPhylogenyoftheTurkey,Meleagrisgallopavo.AnimalGenetics.40:134-141.IF=2.2
(28)GuanX.,T.Geng,P.Silva,andE.J.Smith.(2007).MitochondrialDNASequenceandHaplotypeVariationAnalysisintheChicken(Gallusgallus).JournalofHeredity.98:723-726.IF=2.2
(29)Lin,K.C.,J.Xu,D.F.Kamara,T.Geng,K.B.Gyenai,K.M.Reed,&E.J.Smith.(2007).DNAsequenceandhaplotypevariationintwocandidategenesfordilatedcardiomyopathyintheturkey,Meleagrisgallopavo.Genome.50:463-469.IF=1.4
(30)Kamara,D.F.,T.Geng,S.Guynn,K.Hopwood,&E.J.Smith.(2007).Isolationandcharacterizationofmicrosatellitemarkersfromthebudgerigar,Melopsittacusundulates.MolecularEcologyNotes.7:507–509.
(31)KamaraD.F.,K.B.Gyenai,T.Geng,andE.J.Smith.(2007).MicrosatelliteMarker-BasedGeneticAnalysisofRelatednessBetweenCommercialandHeritageTurkeys(Meleagrisgallopavo).PoultryScience.85:46-49.IF=1.7
(32)LinK.C.,K.B.Gyenai,R.L.Pyle,T.Geng,J.Xu,andE.J.Smith.(2006).CandidateGeneExpressionAnalysisofToxin-InducedDilatedCardiomyopathyintheTurkey(Meleagrisgallopavo).PoultryScience.85:2216-2221.IF=1.7
(33)HartmanS.,S.A.Taleb,T.Geng,X.Guan,K.Gyenai,andEJ.Smith(2006).ComparisonofPlasmaUricAcidLevelsinFiveVarietiesoftheDomesticTurkey,Meleagrisgallopavo.PoultryScience.85:1791-1794.IF=1.7
(34)SmithE.J.,T.Geng,E.C.Long,F.Pierson,D.Sponenberg,C.Larson,R.Gogal.(2005).MolecularAnalysisoftheRelatednessofFiveDomesticatedTurkeyStrains.BiochemicalGenetics.43:35-47.IF=0.9
(35)SmithE.J.,D.F.Kamara,G.Pimentel,T.Geng,X.Guan,K.-C.,LinandS.Hartman.(2005).AvianGenomics:ImportantResourcesforUnderstandingVertebrateBiology.CurrentGenomics.6:75-80.IF=2.3
(36)Hartman,S.,G.Touchton,J.Wynn,T.Geng,N.W.Chong,andE.J.Smith.(2005).CharacterizationofExpressedSequenceTagsfromaGallusgallusPinealGlandcDNALibrary.ComparativeandFunctionalGenomics.6:301-306.IF=2.0
(1)美国生物化学与分子生物学(ASBMB)会员;
(2)SigmaXi会;
(3)担任ScientificReports,PlosOne,BMCMedicalGenetics,WorldJournalofGastroenterology,JAnti-CancerAgentsinMedicinalChemistry,JournalofCardiovascularDiseaseResearch,JournalofCancerTherapy的特约评审人

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