个人简历

1.学习经历
2014.09–2015.09美国加州大学戴维斯分校联合培养博士,生化与分子医学专业.
2012.09–2015.11南京农业大学,农业部动物生理生化重点实验室,博士,动物生理生化专业.
2009.09–2012.07河南农业大学,农业部动物生化与营养重点实验,硕士,动物生理生化专业
2005.09–2009.07扬州大学，兽医学院本科，动物医学
2.工作经历
2019.11-扬州大学特聘教授
2019.01-2019.10美国加州大学戴维斯分校助理科学家（Faculty）
2016.03–2019.01美国加州大学戴维斯分校博士后
2015.12–2016.02瑞典农业科学大学,动物科技学院，访问学者
3.荣誉称号和社会任职
(1)2017年23届美国加州大学戴维斯分校医学中心学术年会报告一等奖
(2)美国2016Movement-PCFchallengeaward
(3)2015长三角研究生论坛学术论文一等奖
(4)2014博士研究生国家奖学金
(5)2013南京农业大学韩正康奖学金
(6)2013河南省第二届自然科学学术奖学术论文二等奖
(7)2012河南省优秀硕士研究生毕业论文奖
(8)2012河南农业大学优秀硕士毕业生

研究领域

(1)动物分子营养学;单胃动物营养生理
(2)营养基因组学；表观遗传学
(3)比较医学：生物节律/核受体参与的脂质代谢调控"科研项目
(1)扬州大学高层次人才启动资金。2019.11-
(2)MovemberFoundation-PCFChallengeAward.“TargetingROR-gammawithNovelTherapeuticsforLethalProstateCancer”.100万美元。08/2016-08/2018。青年科学家。
(3)江苏省普通高校研究生科研创新计划“母体营养影响新生仔猪糖代谢的发生机制”（2013CXLX13_292）。2万。2013-2014。主持。
(4)美国国立卫生院（NIH/NCI）。“TherapeutictargetingoforphanNRinER-negativebreastcancer（R01CA224900）”。216万美元。11/08/2018-9/30/2023.Keyinvestigator。
(5)美国国立卫生院（NIH/NCI）。“Targetingkeyorphannuclearreceptorinlethalprostatecancer（RO1CA206222）”。196万美元。03/08/2016-02/28/2021.Keyinvestigator。
(6)USDepartmentofVeteransAffairsVABLR&DMERITaward.“Novelepigeneticregulatorsincancerresistanceandasnewtargets（I01BX002237-01）”。163万美元。04/01/2014-02/28/2018。Keyinvestigator。
(7)美国国防部DepartmentofDefense（DoD）“AnNRaxisasanoveldeterminatedofARinCRPC（PC150758）”。59万美元。07/01/2016-06/30/2019.Keyinvestigator。
(8)科技部“973”项目子课题“母体营养影响子代肉品质的代谢程序化机制(2012CB124703)”。450万。2012-2016。主要参与。
专利
“Methodsfortreatingcancerwithrorgammainhibitors”.HongwuChen

近期论文

(1)CaiD,WangJ,GaoB,LiJ,WuF,ZouJX,XuJ,JiangY,ZouH,HuangZ,BorowskyAD,BoldRJ,LaraPN,LiJJ,ChenX,LamKS,ToKF,KungHJ,FiehnO,ZhaoR,EvansRM,ChenHW.RORγisatargetablemasterregulatorofcholesterolbiosynthesisinacancersubtype.NatCommun.2019Oct11;10(1):4621.（综合一区,IF:11.87）
(2)WangJ,ZouJX,XueX,CaiD,ZhangY,DuanZ,XiangQ,YangJC,LouieMC,BorowskyAD,GaoAC,EvansCP,LamKS,XuJ,KungHJ,EvansRM,XuY,ChenHW.ROR-γdrivesandrogenreceptorexpressionandrepresentsatherapeutictargetincastration-resistantprostatecancer.NatMed.2016May;22(5):488-96.(医学一区，IF:30.36)
(3)CongR,QuX,ZhangH,HuY,YeS,CaiD*,LiX,LiuHY.Maternalhigh-proteindietmodulateshepaticgrowthaxisinweaningpigletsbyreprogrammingtheIGFBP-3gene.EurJNutr.2019Sep30(*通讯作者,营养学二区,IF:4.45).
(4)LiuHY,WaldenTB,CaiD*,AhlD,BertilssonS,PhillipsonM,NymanM,HolmL.DietaryFiberinBilberryAmelioratesPre-ObesityEventsinRatsbyRegulatingLipidDepot,CecalShort-ChainFattyAcidFormationandMicrobiotaComposition.Nutrients.2019Jun15;11(6).pii:E1350.(*通讯作者,营养学二区,IF:4.17)
(5)CaiD,WangJ,JiaY,LiuH,YuanM,DongH,ZhaoR.Gestationaldietarybetainesupplementationsuppresseshepaticexpressionoflipogenicgenesinneonatalpigletsthroughepigeneticandglucocorticoidreceptor-dependentmechanisms.BBA-MOLCELLBIOLL.2016Jan;1861(1):41-50.(生物学二区,IF:5.55)
(6)CaiD,YuanM,JiaY,LiuH,HuY,ZhaoR.Maternalgestationalbetainesupplementation-mediatedsuppressionofhepaticcyclinD2andpresenilin1geneinnewbornpigletsisassociatedwithepigeneticregulationoftheSTAT3-dependentpathway.JNutrBiochem.2015Dec;26(12):1622-31.（营养学一区,IF:4.68）
(7)CaiD,YuanM,LiuH,HanZ,PanS,YangY,ZhaoR.EpigeneticandSP1-mediatedregulationisinvolvedintherepressionofgalactokinase1geneintheliverofneonatalpigletsborntobetaine-supplementedsows.EurJNutr.2017Aug;56(5):1899-1909.(营养学二区,IF:4.42)
(8)CaiD,YuanM,LiuH,PanS,MaMHongJ,ZhaoR.MaternalBetaineSupplementationthroughoutGestationandLactationModifiesHepaticCholesterolMetabolicGenesinWeaningPigletsviaAMPK/LXR-MediatedPathwayandHistoneModification.Nutrients.2016October.(营养学二区,IF:3.76)
(9)CaiD,JiaY,LuJ,YuanM,SuiS,SongH,ZhaoR.Maternaldietarybetainesupplementationmodifieshepaticexpressionofcholesterolmetabolicgenesviaepigeneticmechanismsinnewbornpiglets.BrJNutr.2014Nov14;112(9):1459-68.(营养学二区,IF:3.34)
(10)CaiD,JiaY,SongH,SuiS,LuJ,JiangZ,ZhaoR.Betainesupplementationinmaternaldietmodulatestheepigeneticregulationofhepaticgluconeogenicgenesinneonatalpiglets.PLoSOne.2014Aug25;9(8):e105504.(综合三区,IF:3.53)
(11)CaiD,LiuH,ZhaoR.Nuclearreceptorsinhepaticglucoseandlipidmetabolismduringneonatalandadultlife.CurrProteinPeptSci.2016Jun26.(生物学三区,IF:3.15)
(12)CaiD,LiuH,YuanM,PanS,JiaY,ZhaoR.ExpressionofhepaticmiRNAstargetingporcineglucocorticoidreceptor(GR)3'UTRintheneonatalpigletsunderamaternalgestationalbetainesupplementation.DataBrief.2015Nov26;6:4-7.
(13)CaiD,LiH,ZhouB,HanL,ZhangX,YangG,YangG.ConjugatedlinoleicacidsupplementationcausedreductionofPerilipin1andaberrantlipolysisinepididymaladiposetissue”.BiochemBiophysResCommun.2012Jun15;422(4):621-6.(生物学三区,IF:2.48)
(14)CaiD,ZhangXandChenH.TNBCco-optionofanewmasterregulatorofcholesterolbiosynthesisprovidesauniquetherapeuticopportunity.2019.Molecular&CellularOncology.
(15)WangJ,WangH,WangLY,CaiD,DuanZ,ZhangY,ChenP,ZouJX,XuJ,ChenX,KungHJ,ChenHW.SilencingtheepigeneticsilencerKDM4AforTRAILandDR5simultaneousinductionandantitumortherapy.CellDeathDiffer.2016Sep9.(生物学一区,IF:8.22)
(16)ZhangX,YangR,JiaY,CaiD,ZhouB,QuX,HanH,XuL,WangL,YaoY,YangG.“HypermethylationofSp1bindingsitelinkspostnatalsuppressionofhypothalamicPOMCgeneandmetabolicchanges:impactofmaternallydietaryCLA”.Diabetes.2014May;63(5):1475-87.（医学一区,IF:8.47）
其他合作论文
(1)PanS,JiaY,YangX,CaiD,LiuZ,SongH,ZhaoR.Aminoacidstarvation-inducedautophagyisinvolvedinreducedsubcutaneousfatdepositioninweaningpigletsderivedfromsowsfedlow-proteindietduringgestationandlactation:Autophagyisinvolvedinreducedfatdepositioninmaternallow-proteinpiglets.EurJNutr.2018Apr;57(3):991-1001.
(2)MaW,LuJ,JiangS,CaiD,PanS,JiaY,ZhaoR.Maternalproteinrestrictiondepressestheduodenalexpressionofirontransportersandserumironlevelinmaleweaningpiglets.BrJNutr.2017Apr;117(7):923-929.
(3)JiaY,HongJ,LiH,HuY,JiaL,CaiD,ZhaoR.Butyratestimulatesadiposelipolysisandmitochondrialoxidativephosphorylationthroughhistonehyperacetylation-associatedβ3-adrenergicreceptoractivationinhigh-fatdiet-inducedobesemice.ExpPhysiol.2017Feb1;102(2):273-281.
(4)HuY,SunQ,LiuJ,JiaY,CaiD,IdrissAA,OmerNA,ZhaoR.Inovoinjectionofbetainealleviatescorticosterone-inducedfattyliverinchickensthroughepigeneticmodifications.SciRep.2017Jan6;7:40251.
(5)YangY,LiX,SunQ,HeB,JiaY,CaiD,ZhaoR.FolatedeprivationinducescellcyclearrestatG0/G1phaseandapoptosisinhippocampalneuroncellsthroughdown-regulationofIGF-1signalingpathway.IntJBiochemCellBiol.2016Oct;79:222-230.
(6)HongJ,JiaY,PanSh,JiaL,LiH,HanZh,CaiD,ZhaoR.Butyratealleviateshighfatdiet-inducedobesitythroughactivationofadiponectin-mediatedpathwayandstimulationofmitochondrialfunctionintheskeletalmuscleofmice.Oncotarget.2016Aug12.
(7)JiaY,SongH,GaoG,CaiD,YangX,ZhaoR.MaternalBetaineSupplementationduringGestationEnhancesExpressionofmtDNA-EncodedGenesthroughD-LoopDNAHypomethylationintheSkeletalMuscleofNewbornPiglets.JAgricFoodChem.2015Nov25;63(46):10152-60.PMID:26527363
(8)PanS,YangX,JiaY,LiY,ChenR,WangM,CaiD,ZhaoR.Intravenousinjectionofmicrovesicle-deliverymiR-130balleviateshigh-fatdiet-inducedobesityinC57BL/6micethroughtranslationalrepressionofPPAR-γ.JBiomedSci.2015Oct16;22:86.PMID:26475357
(9)JiaY,GaoG,SongH,CaiD,YangX,ZhaoR.Low-proteindietfedtocrossbredsowsduringpregnancyandlactationenhancesmyostatingeneexpressionthroughepigeneticregulationinskeletalmuscleofweaningpiglets.EurJNutr.2016Apr;55(3):1307-14.PMID:26066356
(10)HuY,SunQ,LiX,WangM,CaiD,LiX,ZhaoR.InOvoinjectionofbetaineaffectshepaticcholesterolmetabolismthroughepigeneticgeneregulationinnewlyhatchedchicks.PLoSOne.2015Apr10;10(4):e0122643.PMID:25860502
(11)LiX,SunQ,LiX,CaiD,SuiS,JiaY,SongH,ZhaoR.DietarybetainesupplementationtogestationalsowsenhanceshippocampalIGF2expressioninnewbornpigletswithmodifiedDNAmethylationofthedifferentiallymethylatedregions.EurJNutr.2015Oct;54(7):1201-10.PMID:25410747
(12)SuiS,JiaY,HeB,LiR,LiX,CaiD,SongH,ZhangR,ZhaoR.MaternalLow-proteinDietAltersOvarianExpressionofFolliculogenicandSteroidogenicGenesandTheirRegulatoryMicroRNAsinNeonatalPiglets.Asian-AustralasJAnimSci.2014Dec;27(12):1695-704.PMID:25358362
(13)SuiS,HeB,JiaY,LiR,CaiD,LiX,SongH,JiaL,ZhaoR.Maternalproteinrestrictionduringgestationandlactationprogramsoffspringovariansteroidogenesisandfolliculogenesisintheprepubertalgilts.JSteroidBiochemMolBiol.2014Sep;143:267-76.PMID:24787658
著作
Bookchapter:CaiD,LiuH,HuY,JiangY,andZhaoR.“GestationalBetaine,LiverMetabolism,andEpigenetics”.HandbookofNutrition,DietsandEpigenetics.SpringerNature;2017July;pp1-14.10.1007/978-3-319-31143-2_82-1
美国动物科学协会(ASAS)会员，美国癌症协会会员（AACR）。ECnutrition编委；FrontiersinVeterinaryScience特邀编辑。CancerLetters；ScientificReports；MolecularNutritionandFoodResearch；EuropeanJournalofNutrition；Nutrients；InternationalJournalofMolecularSciences；Epigenomes；Metabolites期刊审稿人。