个人简历

1.学习简历
1987.09-1991.07安徽科技学院学士
1991.08-1996.07中国农业大学博士
2.工作简历
1996.08-1998.12中国农业大学讲师
1998-2000新西兰AgResearch分子胚胎实验室合作研究
1999.01-2003.09中国农业大学副教授，硕导
2011.10-2012.10美国西北大学医学院生殖医学中心博士后
2003.10-至今中国农业大学教授，博导
2015.05-至今扬州大学特聘教授，博导

研究领域

（1）从miRNA角度探索了猪生殖细胞的热应激抵御与损害机制。
（2）发现BimEL蛋白在调控哺乳动物卵泡闭锁中发挥关键作用。
（3）发现反刍动物妊娠信号IFN-τ自分泌调控牛、羊早期胚胎发育的分子机制。据此理论设计的新型胚胎培养液和移植液能明显提高牛胚胎体外发育率和移植后受胎率。
（4）提出哺乳动物卵子老化新机制。
（5）积极开展牛、绵羊、山羊、马和驴的胚胎移植和繁殖控制技术的推广工作"近年主持的科研项目：
1、国家“十一五”科技支撑计划（2006BAD14B08-05）“畜禽良种资源高效繁殖和生殖健康关键技术研究与产业化示范”子课题“羊高效排卵控制技术与推广示范”（2006－2008），经费18万。
2、国家“十一五”科技支撑计划（2008BAD2B09）“优质种用肉牛肉羊扩繁技术研究”子课题“高效肉羊胚胎生产技术的研究”（2008－2010），经费30万。
3、国家“十一五”863计划（2008AA101003）“家畜卵泡高效诱导发育技术研究与应用”子课题“猪高效胚胎体外生产体系的研究”（2008－2010），经费15万。
4、国家动物转基因专项(2008ZX08008-005)“转基因抗病羊的培育”子课题“抗布氏杆菌病转基因羊的培育”（2008－2010），经费20万。
5、教育部科学技术研究重点项目（109018）“MicroRNAs对猪卵泡闭锁的调控机制”(2009－2010)，经费10万。
6、高等学校博士学科点专项科研基金“Ca2+离子对猪体外成熟卵母细胞组蛋白乙酰化”（2010－2012）

近期论文

1.GaoFang-Fang,WuZhong-YiandZengShen-Ming.Bovineinterferon-tauexpressioninEscherichiacoliandidentificationofitsbiologicalactivities.ChineseJournalofAgriculturalBiotechnology5(3);189–195;2008.
2.ShuaishuaiWU,HengCHEN,YingzhengWANG,HuiGAO,ShenmingZENG.EffectofcalciumonporcineICSIembryosexpressingEGFPisrelatedtoactivationofooplasmicDNaseI.Front.Agr.Sci.Eng.2015,2(1):84–89.
3.Y.Yuan,Z.D.Hao,J.Liu,Y.Wu,L.Yang,G.S.Liu,J.H.Tian,S.E.Zhu,S.M.Zeng.Heatshockatthegerminalvesiclebreakdownstageinducesapoptosisinsurroundingcumuluscellsandreducesmaturationratesofporcineoocytesinvitro.Theriogenology.2008.70:168–178.
4.CuiMao-sheng,Yi-pengFan,Jin-haoLiu,YiWu,Ze-dongHao,Peng-chengWan,LinYang,Fang-fangGao,ShenLiu,HenChen,Shen-mingZeng.Porcinecumuluscellinfluencesooplasmicmitochondria–lipiddistributions,GSH–ATPcontentsandcalciumreleasepatternafterelectro-activation.Theriogenology71(2009)412–421.
5.YaoNing,Peng-chengWan,Ze-dongHao,Fang-fangGao,LingYang,Mao-shengCui,YiWu,Jing-haoLiu,ShenLiu,HengChen,Guo-shiLiu,Jian-huiTian,Shi-enZhuandShen-mingZeng.Expressionofinterferon-taumRNAinbovineembryosderivedfromdifferentprocedures.Reprod.Dom.Anim.44,132–139(2009).
6.YiWu,Cheng-JunLiu，Peng-ChengWan,Ze-DongHao,Shen-MingZeng.FactorsaffectingtheefficiencyofproducingporcineembryosexpressingenhancedgreenfluorescenceproteinbyICSI-mediatedgenetransfermethod.Anim.Reprod.Sci.113：156–166(2009).
7.Ze-DongHao,LiuS,WuY,WanPC,CuiMS,ChenH,Shen-MingZeng.Thechangesinmitochondria,lipiddroplets,ATPandglutathionecontentsinporcineoocyteduringageinginvitroassociatewithdecreasingCa2+releaseandpoordevelopmentalcompetenceafterelectro-activation.ReproductionFertilityandDevelopment21:323-332,2009.
8.Peng-chengWan,Ze-dongHao,PingZhou,YiWu,LingYang,Mao-shengCui,Shou-renLiu,Shen-mingZeng.EffectsofSOFandCR1mediaondevelopmentalcompetenceandcellapoptosisofovineinvitrofertilizationembryos.Anim.Reprod.Sci.114:279–288,2009.
9.YangL.,X.L.Wang,P.C.Wan,L.Y.Zhang,Y.Wu,D.W.Tang,andS.M.Zeng.Up-regulationofexpressionofinterferon-stimulatedgene15inthebovinecorpusluteumduringearlypregnancy.J.DairySci.93:1000-1011;2010.
10.Mao-ShengCui,Xian-LongWang,Da-WeiTang,JingZhang,YanLiu,Shen-MingZeng.AcetylationofH4K12inporcineoocytesduringinvitroaging:potentialroleofooplasmicreactiveoxygenspecies.Theriogenology.2011.75:638–646.
11.TangD.W.andS.M.Zeng.RelationshipsofCa2+oscillationsandERclusterdistributiontoporcineoocytefragmentation.Asianjournalofanimalandveterinaryadvances.2011.6(4):322-332.
12.Peng-chengWan,Zhong-jianBao,YiWu,LingYang,Ze-dongHao,Yong-linYang,Guo-qingShi,YanLiuandShen-mingZeng.αvβ3integrinmayparticipateinconceptusattachmentbyregulatingmorphologicchangesoftheendometriumduringperiimplantationinovine.Reprod.Dom.Anim.2011.46(5):757-942.
13.AhmedS.Abdoon,OmaimaM.Kandil,ShenM.ZengandCuiMS.Mitochondrialdistribution,ATP-GSHcontents,calcium[Ca2+]oscillationduringinvitromaturationofdromedarycameloocytes.Theriogenology76(2011)1207–1214.
14.WuYi,Cheng-JunLiu，Peng-ChengWan,Ze-DongHao,Shen-MingZeng.BIMEL-mediatedapoptosisincumuluscellscontributestodegenerativechangesinagedporcineoocytesviaaparacrineaction.Theriogenology2011,76:1487-1495.
15.CuiMao-sheng,LIUZhen-xing,Xian-longWang,JingZhang,YiWu,Guo-caiHan,Shen-mingZeng.RelationshipbetweenDifferentialExpressionofBaxandBcl-2GenesandDevelopmentalDifferencesofPorcineParthenotesCulturedinPZM-3andNCSU-23.AgriculturalSciencesinChina,2011,10(11):1772-1780.
16.Xian-LongWang,YiWu,Lu-BinTan,ZhenTian,Jing-HaoLiu,De-ShengZhu,andShen-MingZeng.Follicle-stimulatinghormoneregulatesPro-apoptoticproteinBcl-2-interactingmediatorofcelldeath-extralong(BimEL)inducedporcinegranulosacellapoptosis.TheJournalofBiologicalChemistry,2012,287(13):10166–10177.
17.LingYang,Le-YingZhang,Cheng-MingWang,BinWang,Xue-MinWangandShen-MingZeng.DifferentialexpressionpatternofISG15indifferenttissueexplantsandcellsinducedbyvariousinterferons.MicrobiologyandImmunology,2012;56:163–170.
18.Xian-LongWang,KunWang,Guo-CaiHan,Shen-MingZeng.Apotentialautocrineroleforinterferontauinovinetrophectoderm.Reprod.Dom.Anim.2013;48:819–825.
19.Xian-LongWang,KunWang,Shen-MingZeng.Oocyte-secretedgrowthdifferentiationfactor9inhibitsBCL-2-interactingmediatorofcelldeath-extralongexpressioninporcinecumuluscell.BiologyofReproduction.2013,89:56-64.
20.Da-WeiTang,YuanFang,Zhen-XingLiu,YiWu,Xian-LongWang,ShuanZhao,Guo-CaiHanandShen-MingZeng.TheDisturbancesofEndoplasmicReticulumCalciumHomeostasisCausedbyIncreasedIntracellularReactiveOxygenSpeciesContributestoFragmentationinAgedPorcineOocytes.BiologyofReproduction.2013,89:124-131.
21.LiuZ,ZhaoS,WuS,ZhangJ,NieZ,ZengS.Anovelroleoftransientreceptorpotentialmucolipin1(TRPML1)inprotectingagainstimidazole-inducedcytotoxicity.BiochemCellBiol.2014,92(4):279-86.
22.Zhong-JianBao,ShuanZhao,IhteshamUlHaqandShen-MingZeng.Recombinantbovineinterferon-τenhancesinvitrodevelopmentofbovineembryosbyupregulatingexpressionofconnexin43andE-cadherin.J.DairySci.2014;97(11):6917-25.
23.YuGuangmin,IhteshamulHaq,SherHayatKhanandZengMingsheng.ActinFilamentsareNecessaryforFSH-InducedCYP19A1TranscriptioninBovineGranulosaCellsinvitro.PakistanVeterinaryJournal,2015,35(1):53-57.
24.ZhenxingLiu,YingzhengWang,ShuanZhao,JingyouZhang,YiWuandShenmingZeng.ImidazoleinhibitsautophagyfluxbyblockingautophagicdegradationandtriggersapoptosisviaincreasingFoxO3a-Bimexpression.InternationalJournalOncology.2015,46(2):721-31.
25.ZhaoS,LiuZ-X,BaoZ-J,WuY,WangK,YuG-M,WangC-M,ZengS-M.Age-associatedpotencydeclineinbovineoocytesisdelayedbyblockingextracellularCa2+influx.Theriogenology.2015,83(9):1493–1501.
26.ShuanZhao,Zhen-XingLiu,HuiGao,YiWu,YuanFang,Shuai-ShuaiWu,Ming-JieLiJia-HuaBai,YanLiu,AlexanderEvans,Shen-MingZeng.Athree-dimensionalculturesystemusingalginatehydrogelprolongshatchedcattleembryodevelopmentinvitro.Theriogenology2015,84(2):184-192.
27.YFang,WShang,DLWei,SMZeng.Cited2proteinlevelincumuluscellsisabiomarkerforhumanembryoqualityandpregnancyoutcomeinoneinvitrofertilizationcycle.FertilityandSterility.Availableonline23January2016.
28.HuiGao,LuLin,IhteshamUlHaq,Shen-mingZeng.InhibitionofNF-κBpromotesautophagyviaJNKsignalingpathwayinporcinegranulosacells.BiochemicalandBiophysicalResearchCommunications.2016,473:311–316.
29.ShuanZhao,YiWu,HuiGao,AlexanderEvansandShen-MingZeng.Rolesofinterferon-stimulatedgene15proteininbovineembryodevelopment.Reproduction,FertilityandDevelopment.http://dx.doi.org/10.1071/RD15209,2016.
30.JieyunLi,HuiGao,ZhenTian,YiWu,YingzhengWang,YuanFang,LuLin,YingHan,ShuaishuaiWu,IhteshamUlHaqandShenmingZeng.Effectsofchronicheatstressongranulosacellapoptosisandfollicularatresiainmouseovary.JournalofAnimalScienceandBiotechnology.2016,7:57-67.
31.Guang-MinYu,Jia-HuaBai,YanLiu,TeruoMaeda,Shen-MingZeng。AweeklypostpartumPGF2aprotocolenhancesuterinehealthindairycows.ReproductiveBiology.2016,16(4):295–299.
32.IhteshamUlHaq,YingHan,TariqAli,YingzhengWang,HuiGao,LuLin,YiWu,ShuaishuaiWu,ShenmingZeng.Expressionofinterferon-stimulatedgeneISG15andubiquitinationenzymesisupregulatedinperipheralbloodmonocyteduringearlypregnancyindairycattle.ReproductiveBiology.2016,16(4):255–260.
33.DanYi,ShenmingZeng,YumingGuo.DecreasedSpermQualityinMiceFedaDietwithFishOil.J.Ani.Sci.andBiotech.2011,2(3):164-172.
34.D.Yi,S.Zeng,Y.GuoAdietrichinn-3polyunsaturatedfattyacidsreducedprostaglandinbiosynthesis,ovulationrate,andlittersizeinmice.doi:10.1016/j.theriogenology.2012.01.013
35.GouK.M.,X.R.An,H.Guan,X.Y.Yang,J.Hou,S.E.Zhu,S.M.Zeng,J.H.TianandY.F.Chen.Transgenictwinlambsclonendbygranulosecells.CloningandStemCells.5(1):71-77,2003.
36.QuanGB,TYWu,SMZeng,ZCZhang,SEZhu.Astudyofthecryopreservationofmousezygotesbyopenpulledstrawmethod.Cryobiology2005,50:224.
37.TianXZ,WenQ,ShiJM,Liang-Wang,ZengSM,TianJH,ZhouGB,ZhuSE,LiuGS.Effectsofmelatoninoninvitrodevelopmentofmousetwo-cellembryosculturedinHTFmedium.EndocrRes.2010;35(1):17-23.
38.ShiJM,TianXZ,ZhouGB,WangL,GaoC,ZhuSE,ZengSM,TianJH,LiuGS.Melatoninexistsinporcinefollicularfluidandimprovesinvitromaturationandparthenogeneticdevelopmentofporcineoocytes.J.PinealRes.2009,47(4):318-323.
39.ZhouGB,MaCB,LiuGS,ZhuSE,ZhangHH,JiaLL,SuoL,ShiJM,WangYB,TianJH,ZengSM.VitrificationoffarmedbluefoxoocytesinethyleneglycolandD\
中国畜牧兽医学会动物繁殖学分会、马学分会常务理事、中国奶业协会理事、中国畜牧兽医学会高级会员；AmericanSocietyforBiochemistryandMolecularBiology(ASBMB)会员。