个人简历

太虎林，男，1979年生，副教授，硕士生导师，延边大学“高端人才梯队培育”，“青年图们江学者A类”。主要从事金属酶，金属蛋白，以及四链DNA的研究。主持过国家自然科学基金-面上项目，日本学术振兴会-基盤研究C（相当于国自然-面上项目）和若手研究B（相当于国自然-青年基金），参与过1项日本学术振兴会-挑战萌芽研究基金。曾获得三菱UFJ信託奨学財団博士研究生奖学金资助。迄今为止，在Science，Journal of the American Chemical Society，Angewandte Chemie International Edition等学术期刊发表学术论文38篇（综述3篇），著作1篇。
教育经历
2003.4-2008.3 筑波大学（日本） 数理物质科学研究科 化学专业 理学博士（硕博连读） Supervisor: Prof. Yasuhiko Yamamoto
2002.9-2003.3 筑波大学（日本） 数理物质科学研究科 化学专业 外国人研究生 Supervisor: Prof. Yasuhiko Yamamoto
1998.9-2002.7 吉林大学 化学学院 化学工程与工艺专业 工学学士 Supervisor: Prof. Li Qi (CIAS)
工作经历
2019.9-至今 延边大学 理学院 化学系 副教授
2018.8-2019.9 中山大学 化学学院 特聘副研究员一级
2013.4-2018.8 奈良先端科学技术大学院大学（日本） 物质创成科学研究科 博士研究员，助理教授
2008.4-2013.3 筑波大学（日本） 数理物质科学研究科 副研究员，助理教授
兼职
2013.4-2018.3 日本战略研究推进事业CREST（主持：樋口芳樹教授） CREST研究员
2014.5-2015.3，2016.4-2017.3 日本分子科学研究所 邀请研究员
讲授课程
生物功能分子前沿（研究生）
综合化学实验二
有机化学实验I

研究领域

1. 生物无机化学
2. 蛋白质/核酸化学生物学
3. 人工金属酶的分子设计及应用"科研项目
国家自然科学基金-面上项目，主持，项目编号：21977125，项目费用：66万元，2020/01/01−2023/12/31
延边大学“高端人才梯队培育”基金，主持，项目编号：602019102，项目费用：50万元，2019/10/01−2022/9/30
延边大学“博士启动基金”，主持，项目编号：602020100，项目费用：6万元，2020/7/01−2023/6/30
日本学术振兴会-基盤研究C(相当于国自然-面上项目)，主持，项目编号：JP18K05318，项目费用：442万日元，2018/4/1−2021/3/31
日本学术振兴会-若手研究B(相当于国自然-青年科学基金)，主持，项目编号：JP16K17936，项目费用：416万日元，2016/4/1−2018/3/31
日本学术振兴会-挑戦的萌芽研究，参与，项目编号：JP23655151，项目费用：403万日元(分担费用：60万日元)，2011/4/1−2013/3/31"

近期论文

H. Tai* and S. Hirota*
Mechanism and Application of the Catalytic Reaction of [NiFe] Hydrogenase: Recent Developments
ChemBioChem, 21, 1573–1581 (2020). Invited Concept, VIP IF2.579
H. Tai, K. Nishikawa, Y. Higuchi, Z.-W. Mao, and S. Hirota*
Cysteine SH and glutamate COOH contributions to [NiFe] hydrogenase proton transfer revealed by highly sensitive FTIR spectroscopy
Angewandte Chemie International Edition, 58, 13285-13290 (2019). IF12.959
H. Tai, Y. Higuchi, and S. Hirota*
Comprehensive reaction mechanisms at and nearby the Ni‒Fe active sites of [NiFe] hydrogenases
Dalton Transactions, 47, 4408-4423 (2018). Invited Perspective IF4.052
N. D. M. Noor,† H. Matsuura,† K. Nishikawa,† H. Tai,† S. Hirota, J. Kim, J. Kang, M. Tateno, K.-S. Yoon, S. Ogo, S. Kubota, Y. Shomura, and Y. Higuchi*
Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2
Chemical Communications, 54, 12385–12388(2018). IF6.164
Y. Matoba,* S. Kihara, Y. Muraki, N. Bando, H. Yoshitsu, T. Kuroda, M. Sakaguchi, K. Kayama, H. Tai, S. Hirota, T. Ogura, and M. Sugiyama*
Activation mechanism of the Streptomyces tyrosinase assisted by the caddie protein
Biochemistry, 56,5593–5603 (2017). IF2.997
H.Tai, L. Xu,K. Nishikawa, Y. Higuchi, and S. Hirota*
Equilibrium between inactive ready Ni-SIr and active Ni-SIa states of [NiFe] hydrogenase studied by utilizing Ni-SIr-to-Ni-SIa photoactivation
Chemical Communications, 53, 10444–10447(2017). IF6.29
Y. Shomura*, M.Taketa, H. Nakashima, H.Tai, H. Nakagawa, Y. Ikeda, M. Ishii, Y. Igarashi, H. Nishihara, K.-S. Yoon, S. Ogo, S. Hirota, and Y. Higuchi*
Structural basis of the redox switches in the NAD+-reducing soluble [NiFe]-hydrogenase
Science, 357, 928–932 (2017). IF41.058
T. Shibata, Y. Nakayama, Y. Katahira, H. Tai, Y. Moritaka, Y. Nakano, and Y. Yamamoto*
Characterization of the interaction between heme and a parallel G-quadruplex DNA formed from d(TTGAGG)
Biochimica et Biophysica Acta-General Subjects, 1861, 1264–1270 (2017). IF3.679
H. Tai, L. Xu, S. Inoue, K. Nishikawa, Y. Higuchi, and S. Hirota*
Photoactivation of the Ni-SIr state to Ni-SIa state in [NiFe] hydrogenase: FT-IR study on the light reactivity of the ready Ni-SIr state and as-isolated enzyme revisited
Physical Chemistry Chemical Physics, 18, 22025–22030 (2016). IF4.123
H. Tai, K. Nishikawa, S. Inoue, Y. Higuchi, and S. Hirota*
FT-IR characterization of the light-induced Ni-L2 and Ni-L3 states of [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki F
The Journal of Physical Chemistry B, 119, 13668–13674 (2015). IF3.187
Y. Yamamoto*, M.Kinoshita, Y. Katahira, H. Shimizu, Y. Di, T. Shibata, H. Tai, A.Suzuki, and S. Neya
Characterization of heme-DNA complexes composed of some chemically-modified hemes and parallelG-quadruplex DNAs
Biochemistry, 54, 7168–7177 (2015). IF2.876
H. Shimizu, H. Tai, K. Saito, T. Shibata, M. Kinoshita, and Y. Yamamoto*
Characterization of interaction between heme and a parallel G-quadruplex DNA formed from d(TTAGGGT)
Bulletin of the Chemical Society of Japan, 88, 644–652 (2015). BCSJ Award Article IF1.372
H. Tai, K. Nishikawa, M. Suzuki, Y. Higuchi, and S. Hirota*
Control of the tansition between Ni-C and Ni-SIa states by the redox state of the proximal Fe-S cluster in the catalytic cycle of [NiFe] hydrogenase
Angewandte Chemie International Edition, 53, 13817–13820 (2014). IF11.261
Y. Suzuki, H. Tai, K. Saito, T. Shibata, M. Kinoshita, A. Suzuki, and Y. Yamamoto*
Structural characterization of imidazole adducts of heme-DNA complexes
Journal of Porphyrins and Phthalocyanines, 18, 741–751 (2014). IF1.397
R. Nishimura, D. Matsumoto, T. Shibata, I. Ishigami, T. Ogura, H. Tai, T. Matsuo, S. Hirota, S. Neya, A. Suzuki, and Y. Yamamoto*
Electronic control of ligand binding preference in a myoglobin mutant
Inorganic Chemistry, 53, 9156–9165 (2014). Highlighted paper IF4.762
R. Nishimura, T. Shibata, H. Tai, I. Ishigami, S. Yanagisawa, T. Ogura, S. Neya, A. Suzuki, and Y. Yamamoto*
Effect of the electron density of the heme Fe atom on the Fe-histidine coordination bond in deoxy myoglobin
Bulletin of the Chemical Society of Japan, 87, 905–911 (2014). IF2.210
R. Nishimura, T. Shibata, I. Ishigami, T. Ogura, H. Tai, S. Nagao, T. Matsuo, S. Hirota,O. Shoji, Y. Watanabe, K. Imai, S. Neya, A. Suzuki, and Y. Yamamoto*
Electronic control of discrimination between O2 and CO in myoglobin lacking the distal histidine residue
Inorganic Chemistry, 53, 1091–1099 (2014). Highlighted paper IF4.762
H. Tai, K. Tonegawa, T. Shibata, H. Hemmi, N. Kobayashi*, and Y. Yamamoto*
Inversion of the stereochemistry around the sulfur atom of the axial methionine side chain through alteration of amino acid side chain packing in Hydrogenobacter thermophilus cytochrome c552 and its functional consequences
Biochemistry, 52, 4800–4809 (2013). IF3.194
R. Nishimura, T. Shibata, H. Tai, I. Ishigami, T. Ogura, S. Nagao, S. Matsuo, S. Hirota, K. Imai, S. Neya, S. Suzuki, and Y. Yamamoto*
Relationship between electron density of the heme Fe atom and the vibrational frequencies of the Fe-bound carbon monoxide in myoglobin
Inorganic Chemistry, 52, 3349–3355 (2013). IF4.794
T. Shibata, D. Matsumoto, R. Nishimura, H. Tai, A. Matsuoka, S. Nagao, S. Matsuo, S. Hirota, K. Imai, S. Neya, S. Suzuki, and Y. Yamamoto*
Relationship between oxygen affinity and autoxidation of myoglobin
Inorganic Chemistry, 51, 11955–11960 (2012). IF4.593
K. Saito, H. Tai, H. Hemmi, N. Kobayashi*, and Y. Yamamoto*
Interaction between heme and G-quatet in a heme-DNA complex
Inorganic Chemistry, 51, 8168–8176 (2012). IF4.593
Y. Yamamoto*, S. Nagao, Y. Hirai, H. Tai, and A. Suzuki
Field-dependent 19F NMR study of sperm whale myoglobin reconstituted with a ring-fluorinated heme
Polymer Journal, 44, 907–912 (2012). IF1.496
H. Tai, T. Udagawa, S. Mikami, A. Sugimoto, and Y. Yamamoto*
Fine tuning of redox function of Pseudomonas aeruginosacytocheomec551 through structural properties of a polypeptide loop bearing the axial Met residue
Journal of Inorganic Biochemistry, 108, 182–187 (2012). IF3.197
K. Saito, H. Tai, M. Fukaya, T. Shibata, R. Nishimura, S. Neya, and Y. Yamamoto*
Structural characterization of a carbon monoxide adduct of a heme-DNA complex
Journal of Biological Inorganic Chemistry, 17, 437–445 (2012). IF3.289
A. Sato, H. Tai, S. Nagatomo, K. Imai, and Y. Yamamoto*
Determination of Oxygen Binding Properties of the Individual Subunits of Intact Human Adult Hemoglobin
Bulletin of the Chemical Society of Japan, 84, 1107–1111 (2011). IF1.436
H. Tai, K. Irie, S. Mikami, and Y. Yamamoto*
Enhancement of the thermostability of Hydrogenobacter thermophilus cytochrome c552 through extra methylene group into its hydrophobic protein interior
Biochemistry, 50, 3161–3169 (2011). IF3.422
H. Tai, T. Munegumi, and Y. Yamamoto*
Control of the stability of Hydrogenobacter thermophilus cytochrome c552 through alteration of basicity of the N-terminal amino group of the polypeptide chain
Inorganic Chemistry, 49, 10840–10846 (2010). IF4.326
H. Tai, S. Mikami, K. Irie, N. Watanabe, N. Shinohara, and Y. Yamamoto*
Role of a highly conserved electrostatic interaction on the surface of cytochrome c in control of the redox function
Biochemistry, 49, 42–48 (2010). IF3.226
T. Shibata, S. Nagao, M. Fukaya, H. Tai, S. Nagatomo, K. Morihashi, T. Matsuo, S. Hirota, A. Suzuki, K. Imai, and Y. Yamamoto*
Effect of heme modification on oxygen affinity of myoglobin and equilibrium of the acid-alkaline transition in metmyoglobin
Journal of the American Chemical Society, 132, 6091–6098 (2010). IF9.023
T. Shibata, S. Nagao, H. Tai, S. Nagatomo, H. Hamada, H. Yoshikawa, A. Suzuki,and Y. Yamamoto*
Characterization of the acid-alkaline transition in the individual subunits of the human adult and fetal methemoglobins
The Journal of Biochemistry, 147, 217–229 (2010). IF2.145
H. Tai, T. Munegumi, and Y. Yamamoto*
Stability of the heme Fe3+−N-terminal amino group coordination bond in denatured cytochrome c
Inorganic Chemistry, 48, 331–338 (2009). IF4.657
S. Mikami, H. Tai, and Y. Yamamoto*
Effect of the redox-dependent ionization of the heme propionic acid side chain on the entropic contribution to the redox potential of Pseudomonas aeruginosa cytochrome c551
Biochemistry, 48, 8062–8069 (2009). IF3.226
S. J. Takayama, K. Irie, H. Tai, T. Kawahara, S. Hirota, T. Takabe, L. A. Alcaraz, A. Donaire, and Y. Yamamoto*
Electron transfer from cytochrome c to cupredoxins
Journal of Biological Inorganic Chemistry, 14, 821–828 (2009). IF3.600
K. Saito, Y. Nakano, H. Tai, S. Nagatomo, H. Hemmi, H. Mita, and Y. Yamamoto*
Characterization of heme coordination structure in heme-DNA complex possessing gaseous moleclule as an exogenous ligand
Nucleic Acids Symposium Series, 53, 241–242 (2009). IF0.35
H. Tai, S. Kawano, and Y. Yamamoto*
Characterization of N-terminal amino group-heme ligation emerging upon guanidine hydrochloric acid-induced unfolding of Hydrogenobacter thermophilus ferricytochrome c552
Journal of Biological Inorganic Chemistry, 13, 25–34 (2008). IF3.325
H. Tai, S. Nagatomo, H. Mita, Y. Sambongi, and Y. Yamamoto*
Characterization of non-native heme coordination structures emerging upon guanidine hydrochloric acid-induced unfolding of Pseudomonas aeruginosa ferricytochrome c551
Bulletin of the Chemical Society of Japan, 78, 2019–2025 (2005). Selected paper IF1.629
Y. Yamamoto* and H. Tai*
Thermostability and redox activity of cytochrome c
NetsuSokutei, 35, 131–139 (2008).
L. Qi*, H. Tai, and S. Dong
Study on novel net-shaped gel acrylonitrile-dimethacrylate polymer electrolyte
Chemical Research and Application, 17, 720–724 (2005).　 IF0.482
出版物
Y. Yamamoto* and H. Tai*
Control and functional regulation of the heme π-electron system in the G-quadruplex π-space
High Technology Information: Emergence of Highly Elaborated π-Space and It’s Function, Supervisor: Takeshi Akasaka, Atsuhiro Osuka, Shunichi Fukuzumi, Hedeki Kandori, CMC Publishing Co., Ltd., March, 2013.