个人简历

王怀民， 2008年毕业于天津大学，获得学士学位；2015年博士毕业于南开大学，师从杨志谋教授。2015-2019年在美国布兰迪斯大学化学系从事博士后研究，指导老师为Bing Xu教授。2019年加入西湖大学理学院任独立PI。

研究领域

"""""课题组目前主要运用有机化学、材料化学、化学生物学、细胞/分子生物学等开发设计新型生物功能材料，化学生物学工具、活细胞原位标记探针和反应等。方向包括：生物功能材料、水凝胶、多肽组装、纳米医学、活性探针、蛋白质工程。"

近期论文

Wang, J., Hu, L., Zhang, H., Fang, Y., Wang, T., and Wang, H.* Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer, Advanced Materials., (2021), in press\r
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Yang, X., Lu, H., Tao, Y., Zhou, L., and Wang, H.* Spatiotemporal Control over Chemical Assembly in Living Cells by Integration of Acid Catalyzed Hydrolysis and Enzymatic Reaction, Angew. Chem. Int. Ed. Engl., (2021). doi.org/10.1002/anie.202109729\r
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Hu, L., Li, Y.,  Lin. X.,  Huo, X., Zhang, H., and Wang, H* Structure-Based Programming of Supramolecular Assemblies in Living Cells for Selective Cancer Cell Inhibition, Angew. Chem. Int. Ed. Engl., (2021). doi.org/10.1002/anie.202103507\r
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Yang, X., Cao, Z., Lu, H., and Wang, H.* In Situ Construction of Functional Assemblies in Living Cells for Cancer Therapy,  Adv. Healthcare Mater.., (2021): 2100381.\r
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Wang, H.#, Feng, Z.#, Xu, B.*, Intercellular Instructed-Assembly Mimics Protein Dynamics to Induce Cell Spheroids, J. Am. Chem. Soc., (2019). (# co-first authors)\r
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Wang, H., Feng, Z., Xu, B., Assemblies of Peptides in Complex Environment and Their Applications, Angew. Chem. Int. Ed. Engl., (2019).\r
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Wang, H., Feng, Z., Xu, B.*, Instructed‐Assembly as Context‐Dependent Signals for Death and Morphogenesis of Cells, Angew. Chem. Int. Ed. Engl., 58 (2019) 5567-5571.\r
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Wang, H., Feng, Z., Qin, Y., Wang, J., Xu, B.*, Nucleopeptide Assemblies Selectively Sequester Atp in Cancer Cells to Increase the Efficacy of Doxorubicin, Angew. Chem. Int. Ed. Engl., 57 (2018) 4931-4935.\r
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Wang, H., Feng, Z., Del Signore, S. J., Rodal, A. A., Xu, B.*, Active Probes for Imaging Membrane Dynamics of Live Cells with High Spatial and Temporal Resolution over Extended Time Scales and Areas, J. Am. Chem. Soc., 140 (2018) 3503-3509.\r
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Wang, H., Shi, J., Feng, Z., Zhou, R., Wang, S., Rodal, A. A., Xu, B.*, An in Situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3d Cell Spheroids, Angew. Chem. Int. Ed. Engl., 56 (2017) 16297-16301. (VIP paper)\r
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Wang, H., Feng, Z., Xu, B.*, Bioinspired Assembly of Small Molecules in Cell Milieu, Chem. Soc. Rev., 46 (2017) 2421-2436.\r
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Wang, H., Feng, Z., Xu, B.*, D-Amino Acid-Containing Supramolecular Nanofibers for Potential Cancer Therapeutics, Adv. Drug Delivery Rev., 110 (2017) 102-111.\r
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Wang, H, Feng, Z., Lu, A., Jiang, Y., Wu, H., Xu, B.*, Instant Hydrogelation Inspired by Inflammasomes, Angew. Chem. Int. Ed. Engl., 56 (2017) 7579-7583.\r
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Wang, H., Feng, Z., Wu, D., Fritzsching, K. J., Rigney, M., Zhou, J., Jiang, Y., Schmidt-Rohr, K., Xu, B.*, Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells, J. Am. Chem. Soc., 138 (2016) 10758-10761.\r
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Wang, H., Feng, Z., Wang, Y., Zhou, R., Yang, Z., Xu, B.*, Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance, J. Am. Chem. Soc., 138 (2016) 16046-16055.