个人简历

EDUCATION\r
1993-1997, B.S.,Peking University, Department of Chemistry Advisor: Xiulin Ye:\r
Research Training: Total synthesis of lignin family of natural products.\r
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1997-2002, M.S., Ph.D.,The University of Chicago, Advisor: Viresh H. Rawal\r
Research Training: Development of novel asymmetric methodologies and application to complex molecule synthesis\r
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EXPERIENCE\r
2002-2004, Postdoctoral Scholar, California Institute of Technology,\r
Advisor: David W. C. MacMillan Research Training: Enantioselective organocatalysis\r
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2004-2009, Merck & Co., Senior Research Scientist\r
Research focus: Various medicinal chemistry projects including GPR119 agonists, CXCR3 chemokine antagonists, novel antibiotics, etc.\r
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2009-present, Peking University, Shenzhen Graduate School, Principle Investigator.\r
Research focus: Novel organic transformation development and applications to drug-like property studies & general medicinal chemistry.\r

研究领域

"""""The Huang's group proposed the concept of drug-like property oriented synthesis (DPOS). Our research efforts aim to study drug molecule structure-physical property relationships by development of novel synthetic chemistry methods. Drug-like properties are one of the most critical factors for new biological target validation and small molecules successfully passing human clinical trials. Current design of molecular probes and lead compounds is mainly focused on their underlying biological activities

近期论文

Ligand-Controlled C-O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights Li Li, Feifei Song, Xiumei Zhong, Yun-Dong Wu, Xinhao Zhang,* Jiean Chen,* and Yong Huang.* Adv. Synth. Catal. 2019, 361, 1–8\r
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Alcohol-Directed ortho-C–H Alkenylation Li Li, Qinglan Liu, Jiean Chen *, Yong Huang *. Synlett 2019, 30, A-E. DOI: 10.1055/s-0037-1611538\r
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Enantio- and Diastereoselective Hydrofluorination of Enals via N-Heterocyclic Carbene Catalysis Leming Wang, Xinhang Jiang, Jiean Chen,* Yong Huang*. Angew. Chem. Int. Ed. 2019. DOI:10.1002/anie.201902989\r
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N‐Heterocyclic Carbenes as Brønsted Base Catalysts Jiean Chen, Yong Huang. Book Author(s): Akkattu T. Biju. DOI :10.1002/9783527809042.ch9\r
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Dehydrogenative Annulation of γ,δ-Unsaturated Amides and Alkynes via Double C-H Activation Wang Zhen, Li En, He Zhiqi, Chen Jiean, Huang Yong. Acta Phys. -Chim. Sin. 2019, 35, 0001–0009. DOI: 10.3866/PKU.WHXB201811038.\r
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Switching Reaction Pathways by Cooperative Catalysis of N-Heterocyclic Carbene and Lewis Acids Wang Leming, Wang Qian, Chen Jiean*, Huang Yong*. Acta Chim. Sinica 2018, 76, 850—856.\r
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Structure-Based Drug Design and Identification of H2O‑Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo Peichen Pan,† Jiean Chen,§ Xijian Li,§ Miyang Li,§ Huidong Yu,∥ Jean J. Zhao,⊥,# Jing Ni,⊥,#Xuwen Wang,† Huiyong Sun,† Sheng Tian,∇ Feng Zhu,† Feng Liu,∇ Yong Huang,*,§ and Tingjun Hou*,†,‡ J. Med. Chem. 2018, XXX, XXX−XXX. DOI: 10.1021/acs.jmedchem.8b00498\r
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Aerobic Oxidation/Annulation Cascades via Synergistic Catalysis of RuCl3 and N‐Heterocyclic Carbenes Qian Wang, Jiean Chen*, Yong Huang*. Chem. Eur. J. 2018, 24, 12806 – 12810. DOI: 10.1002/chem.201803254 \r
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Enantioselective hydroamidation of enals by trapping of a transient acyl species Pengfei Yuan, Jiean Chen*, Jing Zhao*, Yong Huang*. Angew. Chem. Int. Ed. 2018. 57, 8503 –8507. DOI: 10.1002/anie.201803556\r
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A Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metallate Shift Zhiqi He, Feifei Song, Huan Sun, and Yong Huang*. J. Am. Chem. Soc. 2018, 140, 2693-2699. DOI: 10.1021/jacs.8b00380\r
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Streamlined asymmetric α-difunctionalization of ynones Siyu Peng1, Zhaofeng Wang1, Linxing Zhang, Xinhao Zhang* & Yong Huang*. Nat. Commun. 2018, 9, 375. DOI: 10.1038/s41467-017-02801-9\r
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Enantioselective Cooperative Proton-Transfer Catalysis using Chiral Ammonium Phosphates Linrui Zhang, Pengfei Yuan, Jiean Chen* and Yong Huang*. Chem. Commun., 2018, 54, 1473. DOI: 10.1039/C7CC09549J\r
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Direct Synthesis of Polysubstituted Aldehydes via Visible-Light-Catalysis Fengjin Wu1, Leifeng Wang1, Jiean Chen*, David A. Nicewicz*, Yong Huang*. Angew. Chem. Int. Ed. 2018, 57, 2174-2178. DOI: 10.1002/anie.201712384\r
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Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- and β-C–H bonds through an Allyl–Iridium Intermediate Zhen Wang1, Zhiqi He1, Linrui Zhang and Yong Huang*, J. Am. Chem. Soc., 2018, 140, 735−740. DOI: 10.1021/jacs.7b11351\r
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Amine-Triggered 6p-Electrocyclization–Aromatization Cascade of Ynedienamines Xijian Li, Huidong Yu, and Yong Huang*, Adv. Synth. Catal. 2017, 359, 1379 – 1387\r
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Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type‑I 1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation Peichen Pan, Huidong Yu, Qinglan Liu, et al. Yong Huang*, and Tingjun Hou*, ACS Cent. Sci. 2017, DOI: 10.1021/acscentsci.7b00419\r
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Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation Chao Yang, Feifei Song, Jiean Chen*, and Yong Huang*, Adv. Synth. Catal. 2017, 359, 3496-3502.\r
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Enantioselective β‑Protonation of Enals via a Shuttling Strategy Jiean Chen1, Pengfei Yuan1, Leming Wang, and Yong Huang*, J. Am. Chem. Soc. 2017, 139, 7045−7051. J\r
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Visible Light Mediated [4+2] Cycloaddition of Styrenes Synthesis of Tetralin Derivatives Leifeng Wang, Fengjin Wu, Jiean Chen, David A. Nicewicz,* and Yong Huang*, Angew. Chem. Int. Ed. 2017, 56, 6896-6900.\r
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Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters Fei Wang, Jiean Chen* and Yong Huang*, Synlett 2017,28, 1300-1304. （Invited Synlett Cluster）\r
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A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics Hao Jiang, Li-Ping Xu, Yan Fang, Zhen-Xing Zhang, Zhen Yang,* and Yong Huang*, Angew. Chem. Int. Ed., 2016, 55, 14340 –14344