个人简历

ACADEMIC QUALIFICATIONS\r
Post-doc (2008-2011):Massachusetts Institute of Technology (Advisor: Prof. Peter C. Dedon)\r
Ph.D. (2004-2008):Hong Kong Baptist University (Advisor: Prof. Zongwei Cai)\r
B.Sc. (2001-2004):Hong Kong University of Science and Technology\r
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FELLOWSHIP AND AWARDS\r
2018\

研究领域

"""""Current research focus on developing chromatographic and mass spectrometric methods: 1) to identify and quantify toxic chemicals for food safety testing; 2) to study chemically- and physically-induced damage to biological macromolecules

近期论文

Kwok HC; Chan W*, (2022) Wheatgrass (Triticum aestivum) as an Efficient Phytoremediation Plant for Aristolochic Acid-Contaminated Water and Arable Soil. ACS Agricultural Science & Technology, Accepted.\r
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Zhang J, Chan KK, Chan W*, (2022) Synergistic Interaction of Polycyclic Aromatic Hydrocarbons, Phthalate Esters, or Phenol on DNA Adduct Formation by Aristolochic Acid I: Insights into the Etiology of Balkan Endemic Nephropathy. Chem Res Toxicol, 35(5): 849–857.\r
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Ham YH, Pan G, Chan HW, Chan W*, (2022) LC-MS/MS Quantitation of Formaldehyde-Glutathione Conjugates as Biomarkers of Formaldehyde Exposure and Exposure-Induced Anti-Oxidants: A New Look on an Old Topic. Chem Res Toxicol, 35(5): 858–866.\r
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Chan W*, Jin L, (2022) DNA-Protein Cross-Links Formed by Reacting Lysine with Apurinic/Apyrimidinic Sites in DNA and Human Cells: Quantitative Analysis by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Stable Isotope Dilution. Anal Chem, 94(2): 803-810.\r
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Jin L, Griffith S, Sun Z, Yu JZ, Chan W*, (2021) On the Flip Side of Mask Wearing: Increased Exposure to Volatile Organic Compounds and a Risk-Reducing Solution. Environ Sci Technol, 55(20):14095-14104.\r
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Chan W*, Guo W, Yu JZ, (2021) Polyurethane-Based Face Mask as a Sampling Device for Environmental Tobacco Smoke. Anal Chem, 93(41):13912-13918.\r
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Chan CK, Xiong L, Pavlović NM, Chan W*, (2021) Determination of Aristolochic Acids in Soil, Water and Herbal Plants in Medicinal Plant Cultivation Areas: An Emerging Environmental Contaminant Worth Concerning. ACS Agric Sci Technol, 1(5): 522-528.\r
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Chan W* and Ham YH, (2021) Probing the Hidden Role of Mitochondrial DNA Damage and Dysfunction in the Etiology of Aristolochic Acid Nephropathy. Chem Res Toxicol, 34(8): 1903-1909.\r
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Guo W, Zhang J, Sun Z, Orem W.H, Tatu CA, Radulović NS, Milovanović D, Pavlović NM*, and Chan W*, (2021) Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid I and Balkan Endemic Nephropathy. Environ Sci Technol, 55(13): 9024-9032.\r
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Chan W*, Zhao Y, Chan K-K, (2021) Formation, Stability, and Antioxidative Properties of 2-Methylthioproline and 2-Methylthioprolineglycine in Grape Wines. ACS Food Sci Technol, 1(5): 892-898.\r
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Chan W*, Jin L, Sun Z, Griffith S,* Yu JZ*, (2021) Fabric Masks as a Personal Dosimeter for Quantifying Exposure to Airborne Polycyclic Aromatic Hydrocarbons. Environ Sci Technol, 55(8): 5128-5135.\r
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Chan CK, Chan KKJ, Liu N*, Chan W*, (2021) Quantitation of Protein Adducts of Aristolochic Acid I by Liquid Chromatography−Tandem Mass Spectrometry: A Novel Method for Biomonitoring Aristolochic Acid Exposure Cells. Chem Res Toxicol, 34(1): 144–153.\r
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Ham YH, Chan KKJ, Madej D, Lam H, Chan W*, (2020) Proteomics Study of DNA-Protein Crosslinks in Methylmethanesulfonate and Fe2+-EDTA-Exposed Human Cells. Chem Res Toxicol. 33(11): 2739–2744.\r
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Au CK, Zhang J, Chan CK, Li C, Liu G, Pavlovic NM, Yao J, Chan W*, (2020) Determination of Aristolochic Acids in Vegetables: Nephrotoxic and Carcinogenic Environmental Pollutants Contaminating a Broad Swath of the Food Supply and Driving Incidence of Balkan Endemic Nephropathy.Chem Res Toxicol, 33(9): 2446–2454.\r
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Chan CK, Pan G, and Chan W*, (2020) Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry. J. Mass Spectrom, accepted\r
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Pan GR, Ham YH, Chan HW, Yao J, Chan W*, (2020) LC-MS/MS Coupled With a Stable-Isotope Dilution Method for the Quantitation of Thioproline-Glycine: A Novel Metabolite in Formaldehyde- And Oxidative Stress-Exposed Cells. Chem Res Toxicol, 33(7): 1989-1996.\r
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Ham YH, Chan KJ, Chan W*, (2020) Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability. Chem Res Toxicol. 33(7): 1815-1821.\r
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Chan CK, Tung KK, Pavlović NM, Chan W*, (2020) Remediation of aristolochic acid-contaminated soil by an effective advanced oxidation process. Sci Total Environ. 720:137528. doi: 10.1016/j.scitotenv.2020.137528\r
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Au CK, Chan CK, Tung KK, Zhang J, Chan W*, (2020) Quantitation of DNA Adducts of Aristolochic Acids in Repair-Deficient Cells: A Mechanistic Study of the DNA Repair Mechanism. Chem Res Toxicol. 33(6): 1323-1327.\r
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Zhang J, Chan CK, Ham YH, Chan W*, (2020) Identifying Cysteine, N-Acetylcysteine, and Glutathione Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway. Chem Res Toxicol. 33(6): 1374-1381.