个人简历

2018−present: Norman & Cecilia Yip Professor in Bioinorganic Chemistry\r
2018−present: Chair Professor\r
2007−2018: Professor\r
2004−2007: Associate Professor\r
1998−2004: Assistant Professor, Department of Chemistry, The University of Hong Kong\r
1996− 1998: GlaxoWellcome Research Fellow, Department of Chemistry, The University of Edinburgh, Great Britain\r
1993− 1996: Ph.D., The University of London (Birkbeck College) Great Britain\r
1990− 1993: Research Associate and Lecturer, Coordination Chemistry Institute, Nanjing University, P.R. China

研究领域

"""""Our research interest lies in Biological Inorganic Chemistry

近期论文

Wang H.B., Wang M.J., Xu X.H., Gao P., Xu Z.L., Zhang Q., Li H.Y., Yan A.X., Kao R.Y. -T., Sun H.Z.* “Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance”. Nature Communications, 12, 3331, doi: 10.1038/s41467-021-23659-y.\r
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Yuan S.F., Yin X., Meng X.Z., Chan J.F.W., Ye Z.W., Riva L., Pache L., Chan C.C.Y., Lai P.M., Chan C.C.S., Poon V.K.M., Lee A. C.Y., Matsunaga N., Pu Y., Yuen C.K., Cao J.L., Liang R.H., Tang K.M., Sheng L., Du Y.S., Xu W., Lau C.Y., Sit K.Y., Au W.K., Wang R.M., Zhang Y.Y., Tang Y.D., Clausen T.M., Pihl J., Oh J., Sze K.H., Zhang A.J.X., Chu H., Kok K-H., Wang D., Cai X.H., Esko J.D., Hung I.F.N., Li R.A., Chen H.L., Sun H.Z., Jin D.Y., Sun R., Chanda S.K., Yuen K.Y.* (2021) “Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters”. Nature, doi: 10.1038/s41586-021-03431-4. \r
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Xu X.H., Wang H.B. Li H.Y., Sun H.Z.* (2021) “Dynamic and temporal transcriptomic analysis reveals ferroptosis-mediated anti-leukemia activity of S-dimethylarsino-glutathione: insights into novel therapeutic strategy” CCS Chemistry, 3, 1089-1100. doi: 10.31635/ccschem.021.202000685.\r
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Tse E.C.M.*, Sun H.Z.* (2020) Book review for “Transition Metals and Sulfur –A Strong Relationship for Life”, Metal Ions in Life Sciences, vol. 20, Zeitschrift für Naturforschung C, doi: 10.1515/znc-2020-0252.\r
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Zhou Y., Ip T.K.Y., Zhang Q., Li H.Y., Sun H.Z.* (2020) “Metal complexes as drugs and chemotherapeutic agents” in Comprehensive Coordination Chemistry III (Volume 9: “Applications of Coordination Chemistry”), Elsevier. doi: 10.1016/B978-0-08-102688-5.00018-0.\r
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Wang H.B.*, Yang X.M., Wang M.J., Xu X.H., Hu M.L, Yan A.X., Hao Q., Li H.Y., Sun H.Z.* (2020) “Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm” Chemical Science, 11(43), 11714-11719. doi: 10.1039/D0SC04151C.\r
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Yuan S.F.§, Wang R.M.§, Chan J.F.W.§, Zhang A.J., Cheng T.F., Chik K.K.H., Ye Z.W., Wang S.Y., Lee A.C., Jin L.J., Li H.Y., Jin D.Y., Yuen K.Y.*, Sun H.Z.* (2020) “Metallodrug ranitidine bismuth citrate suppress SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters” Nature Microbiology, 5(11), 1439-1448. doi: 10.1038/s41564-020-00802-x.\r
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Sun H.Z.§*, Zhang Q.§, Wang R.M.§*, Wang H.B., Wong Y.T., Wang M.J., Hao Q., Yan A.X., Kao R.Y.T., Ho P.L., Li H.Y. (2020) “Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin” Nature Communications, 11(1), 5263, doi: 10.1038/s41467-020-18939-y.\r
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Wang R.M., Wang S.Y., Chan S., Zuo Z., Chan G.C.F., Li H.Y., Sun H.Z.* (2020) “Bismuth porphyrin antagonizes cisplatin-induced nephrotoxicity via inactivating caspase-dependent apoptotic pathway” iScience, 23(5), 101054. doi: 10.1016/j.isci.2020.101054.\r
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Tao X., Zhang Z.M., Zhang X., Li H.Y., Sun H.Z.*, Mao Z.W., Xia W.* (2020) “Structural insight into the substrate gating mechanism by Staphylococcus aureus aldehyde dehydrogenase” CCS Chemistry, 2(3), 946-954. doi: 10.31635/ccschem.020.202000219.\r
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Xu X.H., Wang H.B., Li H.Y., Sun H.Z.* (2020) “Metalloproteomic approaches for matching metals to proteins: The power of inductively coupled plasma mass spectrometry (ICP-MS)” Chemistry Letter, 49(6), 697-704. doi: 10.1246/cl.200155. \r
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Kanatzidis M., Sun H.Z., Dehnen S.* (2020) “Bismuth- the magic element” Inorganic Chemistry, 2020, 59(6) 3341-3343. doi: 10.1021/acs.inorgchem.0c00222. \r
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Wang H.B., Zhou Y., Xu X.H., Li H.Y., Sun H.Z.* (2020) “Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: mechanism-driven new therapy development” Current Opinion in Chemical Biology, 55, 171-179. doi: 10.1016/j.cbpa.2020.02.006. (invited)\r
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Wang R.M., Li H.Y., Ip T.K.Y., Sun H.Z.* (2020) “Chapter 6 − Bismuth drugs as antimicrobial agents” Advances in Inorganic Chemistry, 75, 183-205. doi: 10.1016/bs.adioch.2019.10.011.\r
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Jiang N., Wang Y.L., Chan K.C., Sun H.Z.*, Li G.J.* (2020) “Additive manufactured graphene coating with synergistic photothermal and superhydrophobic effects for bactericidal applications” Global Challenges, 4(1), 1900054. doi: 10.1002/gch2.201900054.\r
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Koohi-Moghadam M., Wang H.B., Wang Y.C., Yang, X.M., Li H.Y., Wang J.W.*, Sun H.Z.* (2019) “Predicting disease-associated mutation of metal binding sites of a protein using a deep learning approach” Nature Machine Intelligence, 1(12), 561-567. doi: 10.1038/s42256-019-0119-z. (Highlighted as a ‘news&views’ entitled “DEEP LEARNING IN MEDICINE Predicting cracks in metalloproteins”, 1(12), 553-554)\r
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Xu Z.L., Wang P.C., Wang H.B., Hang Z., Au-Yeung H.Y., Hirayama T. Sun H.Z., Yan A.X. (2019) “Zinc excess leads to an increased cellular demand for iron and decreased tolerance to copper in Escherichia coli” Journal of Biological Chemistry, 294(45), 16978-16991. doi: 10.1074/jbc.RA119.010023.\r
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Xu, X.H., Wang H.B., Li, H.Y., Hu X.Q., Zhang Y., Guan X.Y., Toy P.H., Sun H.Z.* (2019) “S-dimethylarsino-glutathione (darinaparsin®) targets Histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells” Chemical Communications, 55(87), 13120-13123. doi: 10.1039/C9CC07605K.\r
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Jiang N., Li H., Sun H.Z.* (2019) “Recognition of proteins by metal chelation-based fluorescent probes in cells” Frontiers in Chemistry, 7, 560. doi: 10.3389/fchem.2019.00560 \r
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Wang Y.C., Li H.Y., Sun H.Z.* (2019) “Metalloproteomics for unveiling the mechanism of action of metallodrugs and their candidates” Inorganic Chemistry, 58(20), 13673-13685. doi: 10.1021/acs.inorgchem.9b01199. (featured in the Supplementary cover)