个人简历

2018- Professor, HKU\r
2014-2018 Associate Professor, HKU\r
2009-2014 Assistant Professor, HKU\r
2007-2009 Postdoc, Memorial Sloan Kettering Cancer Center(Professor Samuel Danishefsky )\r
2004-2007 Ph.D, Harvard University (Professor Dan Kahne)\r
2000-2003 M.Sc, University of Alberta (Professor Ole Hindsgaul)\r
1995-1999 B.Sc, Nankai University\r
2020 The Cathay Award, Chinese Peptide Society\r
2019 The Rao Makineni Lectureship Award, American Peptide Society\r
2017 Croucher Senior Research Fellowship, Croucher Foundation

研究领域

"""""I. Method developing for Bio-macromolecules synthesis\r
II. Medicinal Chemistry of Natural Products\r
III. Function Definition of Macromolecules and their PTMs\r
IV. Drug Development"

近期论文

Sun, Z.; Ma, W.; Cao, Y.; Wei, T.; Chow, H.Y.; Tan, Y.; Cheung, C.H.P.; Liu, J.; Lee, H.K.; Liu, H.; Li, X.* Superfast Desulfurization for Protein Chemical Synthesis and Modification. Chem 2022. 144, 14748-14757\r
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Wu, H.; Wei, Tong.; Ngai, W. L.; Zhou, H. Y.; Li, X.* Ligation Embedding Aggregation Disruptor Strategy Enables the Chemical Synthesis of PD-1 Immunoglobulin and Extracellular Domains. J. Am. Chem. Soc. 2022. 144, 14748-14757\r
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Chow, H. Y.; Po, K. H. L.; Chen, S.; Li, X.* Studies on daptomycin lactam-based analogues. J. Pept. Sci. 2022. e3430\r
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Liu, J.; Li, X.* Serine/Threonine ligation and Cysteine/Penicillamine ligation. Methods Mol. Biol. 2022. 2530, 33-43. Included in Chemical Protein Synthesis for Methods in Molecular Biology. Springer Nature 2022.\r
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Jarkhi, A.; Lee, A.H.C.; Sun, Z.; Hu, M.; Neelakantan, P.; Li, X.; Zhang, C.* Antimicrobial effects of L-Chg10-teixobactin against Enterococcus faecalis in vitro.Microorganisms 2022. 10, 1099.\r
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Jiang, H.; Zhang, Q.; Zhang, Y.; Feng, H.; Pu, F.; Yu, R.; Zhong, Z.; Wang, C.; Fung, Y. M. E.; Blasco, P.; Li, Y.; Jiang, T.*; Li, X.* Triazin-pyridine chemistry for selective tyrosine labelling of proteins. Chem. Commun. 2022. 58, 7066-7069.\r
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Liu, J.; Wei, T.; Tan, Y.; Li, X.* Enabling chemical protein (semi)synthesis via Reducible solubilizing tags (RST). Chem. Sci. 2022. 13, 1367.\r
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Cheung, C. H. P.; Chow, H. Y.; Li, C.; Chen, K.; Chen, S.; Li X.* Synthesis of daptomycin thiolactone analogue via the MeDbz-linker based cyclative-cleavage approach. Pep. Sci. 2022. 114, e24255 \r
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Li, X.* Long journey on daptomycin. Synlett 2022. 33, 27-33 \r
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Wang, J.; Li, X.* Complex natural product synthesis via Serine/Threonine ligation. Bioorg. Med. Chem. Lett. 2021. 43, 128430\r
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Wei, R.; Yang, X.; Liu, H.; Wei, T.; Chen, S.*; Li, X.* Synthetic pseudaminic-acid-based antibacterial vaccines confers effective protection against Acinetobacter baumannii infection. ACS Cent. Sci. 2021. 7, 1535-1542\r
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Wang, J.; Lin, D.; Liu, M.; Blasco, P.; Sun, Z.; Cheung, Y.C.; Chen, S.; Liu, H.; Li, X.* Total synthesis of mannopeptimycin β via β-Hydroxyenduracididine Ligation. J. Am. Chem. Soc. 2021. 143, 12784-12790\r
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Sun, Z.; Li, X.* Studies on 2-formylphenylboronic acid-based Ser/Thr ligation and Cys/Pen ligation. Chin. J. Chem. 2021. 39, 2795-2800\r
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Wei, T.; Liu, H.; Wu, H.; Fan, P.; Li, X.* Chemical synthesis of HMGA1a with site-specific PTMs for biochemistry study. STAR Protocols 2021. 2, 100777\r
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Po, K. H. L.; Chow, H. Y.; Cheng, Q.; Deng, X.; Wang, S.; Chan, E. W. C.; Chan, K. F.; Li, X.*; Chen, S.* Daptomycin exerts bactericidal effect through induction of excessive ROS production and blocking the function of stress response protein Usp2. Natural Science 2021. 1:e10023\r
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Unarta, I. C.; Xu, J.; Shang, Y.; Cheung, C. H. P.; Zhu, R.; Chen, X.; Cao, S.; Bierer, D.; Zhang, M.; Huang, X*; Li, X.* Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain. RSC Chem. Biol. 2021. 2, 1274-1284\r
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Wu, H.; Zhang, Y.; Li, Y.; Xu, J.; Wang, Y.*; Li, X.* Chemical Synthesis and Biological Evaluation of Adiponectin Collagenous Domain Glycoforms. J. Am. Chem. Soc. 2021, 143, 7808-7818.\r
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Blasco, P.; Zhang, C.; Chow, H. Y.; Chen, G.; Wu, Y.; Li, X.* An atomic perspective on improving daptomycin’s activity. Biochim Biophys Acta Gen Subj. 2021, 1865, 129918.\r
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Zhang, B.Z., Wang, X., Yuan, S., Li, W., Dou, Y., Poon, V.K.M., Chan, C.C.S., Cai, J.P., Chik, K.K., Tang, K., Chan, C.C.Y., Hu, Y.F., Hu,J.C., Badea, S.R., Gong, H.R., Lin, X.S., Chu, H., Li, X., To, K.K., Liu, L., Chen, Z.W., Hung, I.F.N., Yuen, K.Y. A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters. Emerging Microbes & Infection 2021, 10, 874-884.\r
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Cheung, C.; Xu, J.; Lee, C. L.; Zhang, Y.; Wei, R.; Bierer, D.; Huang, X.; Li, X*Construction of diverse peptide structural architectures via chemical ligation. Chem. Sci. 2021, 12, 7091-7097.