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何健
2023-05-15 19:34
  • 何健
  • 何健 - 副教授-香港大学-化学系-个人资料

近期热点

资料介绍

个人简历


EDUCATION\r
California Institute of Technology Postdoctoral Fellow (2016–2019)Advisor: J. C. Peters\r
The Scripps Research Institute Ph.D. in Chemistry (2011–2016)Advisor: J.-Q. Yu\r
Zhejiang University B.S. in Chemistry (2007–2011)Advisor: S. Ma\r
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BIOSKETCH\r
Jian received his B.Sc. degree in Chemistry with highest honors from Zhejiang University, where he conducted research under the direction of Prof. Shengming Ma. In 2011, he moved to the Scripps Research Institute to pursue his graduate studies under the supervision of Prof. Jin-Quan Yu. After completing a two-year appointment as a Postdoctoral Fellow with Prof. Jonas C. Peters at Caltech, Jian joined the faculty at The University of Hong Kong in August of 2019. His research interests lie at the interface of organometallic chemistry, organic synthesis, catalysis, synthetic biology, and materials science. Outside of the lab, Jian enjoys eating delicious food, watching movies, and travelling with his wife and parents.

研究领域


"""""The development of heterogeneous catalysts with high activity

近期论文


Liu, L.-J.; Alkan, F.; Zhuang, S.-L.; Liu, D.; Nawaz, T.; Guo, J.; Luo, X.; He, J.* Atomically Precise Gold Nanoclusters at the Molecular-to-Metallic Transition with Intrinsic Chirality from Surface Layers. Nat. Commun. 2023, 14, 2397.\r
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Ma, B.; Xia, Q.; Wang, D.; Jin, J.-K.; Li, Z.; Liang, Q.-J.; Sun, M.-Y.; Liu, D.; Liu, L.-J.; Shu, H.-X.; Yang, J.; Li, D.;* He, J.* Metal–Organic Framework Supported Copper Photoredox Catalysts for Iminyl Radical-Mediated Reactions. Angew. Chem. Int. Ed. 2023, e202300233. \r
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Zhu, W.; Zhang, S.; Fan, W.; Yang, Y.; Zhao, H.; Fei, W.; Bi, H.; He, J.; Li, M.-B.;* Wu, Z.* Atomically Precise Metal Nanoclusters as Single Electron Transferers for Hydroborylation. Precis. Chem. DOI: 10.1021/prechem.3c00003.\r
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Zhuang, S.-L.; Chen, D.; NG, W.-P.; Liu, D.; Liu, L.-J.; Sun, M.-Y.; Nawaz, T.; Wu, X.; Zhang, Y.; Li, Z.; Huang, Y.-L.; Yang, J.;* Yang, J.;* He, J.* Phosphinous Acid–Phosphinito Tetra-Icosahedral Au52 Nanocluster for Electrocatalytic Oxygen Reduction. JACS Au 2022, 2, 2617–2626.\r
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Wu, X.; Xiong, X.; Li, J.-L.; Luo, D.; Wu, K.; Wei, Y.-B.; Liu, X.-Y.; Lu, W.;* Li, D.; He, J.* An Adenine-Based Biological Metal-Organic Framework as an Efficient Luminescent Sensor for Tetracycline Detection. Eur. J. Inorg. Chem. 2022, e202200278. (VIP)\r
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Jin, J.-K.; Wu, K.; Liu, X.-Y.; Huang, G.-Q.; Huang, Y.-L.; Luo, D.; Xie, M.; Zhao, Y.; Lu, W.;* Zhou, X.-P.;* He, J.;* Li, D.* Building a Pyrazole–Benzothiadiazole–Pyrazole Photosensitizer into Metal–Organic Frameworks for Photocatalytic Aerobic Oxidation. J. Am. Chem. Soc. 2021, 143, 21340–21349.\r
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Wu, Q.-F.; Chen, G.; He, J.; Yu, J.-Q. Catalytic, Enantioselective, C–H Functionalization to Form Carbon–Carbon Bonds. Org. React. 2019, 100, 671−748.\r
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He, J.; Chen, C.; Fu, G. C.; Peters, J. C. Visible-Light-Induced, Copper-Catalyzed Three-Component Coupling of Alkyl Halides, Olefins, and Trifluoromethylthiolate to Generate Trifluoromethyl Thioethers. ACS Catal. 2018, 8, 11741–11748.\r
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Shao, Q.; Wu, Q.; He, J.; Yu, J.-Q. Enantioselective γ-C(sp3)–H Activation of Alkyl Amines via Pd(II)/Pd(0) Catalysis. J. Am. Chem. Soc. 2018, 140, 5322–5325.\r
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He, J.; Wasa, M.; Chan, K. S. L.; Shao, Q.; Yu, J.-Q. Palladium-Catalyzed Transformations of Alkyl C–H Bonds. Chem. Rev. 2017, 117, 8754–8786.\r
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Shao, Q.; He, J.; Wu, Q.; Yu, J.-Q. Ligand-Enabled γ-C(sp3)–H Cross-Coupling of Nosyl-Protected Amines with Aryl- and Alkylboron Reagents. ACS Catal. 2017, 7, 7777–7782.\r
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Wang, H.-W.; Lu, Y.; Zhang, B.; He, J.; Xu, H.-J.; Kang, Y.-S.; Sun, W.-Y.; Yu, J.-Q. Ligand-Promoted Rhodium(III)-Catalyzed ortho-C–H Amination of Benzamides with Free Amines. Angew. Chem. Int. Ed. 2017, 56, 7449–7453.\r
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Pei, Q.-L.; Che, G.-D.; Zhu, R.-Y.; He, J.; Yu, J.-Q. An Epoxide-Mediated Deprotection Method for Acidic Amide Auxiliary. Org. Lett. 2017, 19, 5860–5863.\r
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Zhu, R.-Y.; Saint-Denis, T. G.; Shao, Y.; He, J.; Sieber, J. D.; Senanayake, C. H.; Yu, J.-Q. Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)–H Bonds. J. Am. Chem. Soc. 2017, 139, 5724–5727.\r
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Hoyt, C. B.; Lee, L.-C.; He, J.; Yu, J.-Q.; Jones, C. W. Selective C(sp3)–H Monoarylation Catalyzed by a Covalently Cross-Linked Reverse Micelle-Supported Palladium Catalyst. Adv. Synth. Catal. 2017, 359, 3611–3617.\r
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He, J.; Shao, Q.; Wu, Q.; Yu, J.-Q. Pd(II)-Catalyzed Enantioselective C(sp3)–H Borylation. J. Am. Chem. Soc. 2017, 139, 3344–3347.\r
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Fu, H.; Shen, P.-X.; He, J.; Zhang, F.; Li, S.; Wang, P.; Liu, T.; Yu, J.-Q. Ligand-Enabled Alkynylation of C(sp3)–H Bonds with Pd(II) Catalysts. Angew. Chem. Int. Ed. 2017, 56, 1873–1876.\r
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Wu, Q.-F.; Shen, P.-X.; He, J.; Wang, X.-B.; Zhang, F.; Shao, Q.; Zhu, R.-Y.; Mapelli, C.; Qiao, J. X.; Poss, M. A.; Yu, J.-Q. Formation of α-Chiral Centers by Asymmetric β-C(sp3)–H Arylation, Alkenylation, and Alkynylation. Science 2017, 355, 499–503.\r
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Wang, P.; Li, G.-C.; Jain, P.; Farmer, M.; He, J.; Shen, P.-X.; Yu, J.-Q. Ligand-Promoted Meta-C–H Amination and Alkynylation. J. Am. Chem. Soc. 2016, 138, 14092–14099.\r
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Lee, L.-C.; He, J.; Yu, J.-Q.; Jones, C. W. Functionalized Polymer-Supported Pyridine Ligands for Palladium-Catalyzed C(sp3)–H Arylation. ACS Catal. 2016, 6, 5245–5250.\r
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Jiang, H.;† He, J.;† Liu, T.; Yu, J.-Q. Ligand-Enabled γ-C(sp3)–H Olefination of Amines: En Route to Pyrrolidines. J. Am. Chem. Soc. 2016, 138, 2055–2059.\r
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He, J.; Jiang, H.; Takise, R.; Zhu, R.-Y.; Chen, G.; Dai, H.-X.; Dhar, T. G. M.; Shi, J.; Zhang, H.; Cheng, P. T. W.; Yu, J.-Q. Ligand-Promoted Borylation of C(sp3)−H Bonds with Pd(II) Catalysts. Angew. Chem. Int. Ed. 2016, 55, 785–789.\r
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Zhu, R.-Y.; Tanaka, K.; Li, G.-C.; He, J.; Fu, H.-Y.; Li, S.-H.; Yu, J.-Q. Ligand-Enabled Stereoselective β-C(sp3)−H Fluorination: Synthesis of Unnatural Enantiopure anti-β-Fluoro-α-Amino Acids. J. Am. Chem. Soc. 2015, 137, 7067–7070.\r
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He, J.; Takise, R.; Fu, H.; Yu, J.-Q. Ligand-Enabled Cross-Coupling of C(sp3)–H Bonds with Arylsilanes. J. Am. Chem. Soc. 2015, 137, 4618–4621.\r
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He, J.; Shigenari, T.; Yu, J.-Q. Palladium(0)/PAr3-Catalyzed Intermolecular Amination of C(sp3)–H Bonds: Synthesis of β-Amino Acids. Angew. Chem. Int. Ed. 2015, 54, 6545–6549.\r
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Chen, G.; Shigenari, T.; Jain, P.; Zhang, Z.; Jin, Z.; He, J.; Li, S.; Mapelli, C.; Miller, M. M.; Poss, M. A.; Scola, P. M.; Yeung, K.-S.; Yu, J.-Q. Ligand-Enabled β-C–H Arylation of α-Amino Acids Using a Simple and Practical Auxiliary. J. Am. Chem. Soc. 2015, 137, 3338–3351.\r
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Zhu, D.; Yang, G.; He, J.; Chu, L.; Chen, G.; Gong, W.; Chen, K.; Eastgate, M.; Yu, J.-Q. Ligand-Promoted Ortho-C–H Amination with Pd Catalysts. Angew. Chem. Int. Ed. 2015, 54, 2497–2500.\r
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Zhu, R.-Y.; He, J.; Wang, X.-C.; Yu, J.-Q. Ligand-Promoted Alkylation of C(sp3)–H and C(sp2)–H Bonds. J. Am. Chem. Soc. 2014, 136, 13194–13197.\r
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Deng, Y.; Gong, W.; He, J.; Yu, J.-Q. Ligand-Enabled Triple C–H Activation Reactions: One-Pot Synthesis of Diverse 4-Aryl-2-Quinolinones from Propionamide. Angew. Chem. Int. Ed. 2014, 53, 6692–6695.\r
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He, J.; Li, S.; Deng, Y.; Fu, H.; Laforteza, B. N.; Spangler, J. E.; Homs, A.; Yu, J.-Q. Ligand-Controlled C(sp3)–H Arylation and Olefination in Synthesis of Unnatural Chiral α-Amino Acids. Science 2014, 343, 1216–1220.\r
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He, J.; Wasa, M.; Chan, K. S. L.; Yu, J.-Q. Palladium(0)-Catalyzed Alkynylation of C(sp3)–H Bonds. J. Am. Chem. Soc. 2013, 135, 3387–3390.\r
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Wasa, M.; Chan, K. S. L.; Zhang, X.-G.; He, J.; Miura, M.; Yu, J.-Q. Ligand-Enabled Methylene C(sp3)–H Bond Activation with a Pd(II) Catalyst. J. Am. Chem. Soc. 2012, 134, 18570–18572.\r
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He, J.; Lu, Z.; Chai, G.; Fu, C.; Ma, S. CuCl-Catalyzed Stereoselective Conjugate Addition of Grignard Regents to 2,3-Allenoates. Tetrahedron 2012, 68, 2719–2724.

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