个人简历

Dr. Sun received her B.Sc from Wuhan University in 2003 and Ph.D from National University of Singapore in 2008. Her Ph.D research focuses on systematic enzyme profiling under the supervision of Professor Shao Qin Yao. She was granted a fellowship from Humboldt Foundation and performed postdoc research with Professor Herbert Waldmann at Max Planck Institute of Molecular Physiology from 2008 to 2011. She joined City University of Hong Kong in July 2011.

研究领域

"""""1. Combinatorial synthesis to generate biologically active compound collections

近期论文

Radtke, L.; Willot, M.; Sun, H.; Zeigler, S.; Sauerland, S.; Strohmann, C.; Fröhlich, R.; Habenberger, P.; Waldmann, H.; Christmann, M. Total Synthesis and Biological Evaluation of (-)- Englerin A and B: Synthesis of Analogues with Improved Activity Profile. Angew. Chem. Intl. Ed., 2011, 50, 3998-4002.\r
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Yi, L.;* Sun, H.;* Wu, Y.W.; Triola, G.; Waldmann, H.; Goody, R.S. A Highly Efficient Strategy for Protein C-Terminal Modification. Angew. Chem. Intl. Ed., 2010, 49, 9417-9421. (*, equal contribution) (Selected as Hot Paper)\r
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Gao, L.; Sun, H.; Yao, S.Q. Activity-based high-throughput determination of PTPs substrate specificity using a phosphopeptide microarray. Biopolymers, 2010, 94, 810-819.\r
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Sun, H.; Tan, L.P.; Gao, L.; Yao, S.Q. High-throughput Screening of Catalytically Inactive Mutants of Protein Tyrosine Phosphatases (PTPs) in a Phosphopeptide Microarray. Chem. Commun., 2009, 677-679.\r
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Sun, H.; Lu, C.H.S.; Uttamchandani, M.; Xia, Y.; Liou, Y.-C.; Yao, S.Q. Peptide Microarray for High-throughput Determination of Phosphatase Specificity and Biology. Angew. Chem. Intl. Ed., 2008, 47, 1698-1702.\r
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Lu, C.H.S.; Sun, H.; Bakar, F.B.A.; Uttamchandani, M.; Zhou, W.; Liou, Y.-C.; Yao, S.Q. Deciphering the Substrate Preferences of 14-3-3 Isoforms Using Peptide Microarray, Angew. Chem. Intl. Ed., 2008, 47, 7438-7441.\r
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Sun, H.; Lu, C.H.S.; Shi, H.; Gao, L.; Yao, S.Q. Peptide Microarrays for High-throughput Studies of Ser/Thr Phosphatases, Nat. Protocols, 2008, 3, 1485-1493. \r
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Uttamchandani, M; Li. J.; Sun, H.; Yao, S.Q Activity-Based Profiling: New Developments and Directions in Protein Fingerprinting, ChemBioChem, 2008, 9, 667-675.\r
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Lee, W.L.; Li, J.; Uttamchandani, M.; Sun, H.; Yao, S. Q. Inhibitor Fingerprinting of Metalloproteases Using Microplate and Microarray Platforms – An Enabling Technology in Catalomics Nat. Protocols, 2007, 2, 2126-2138.\r
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Uttamchandani, M.; Wang, J.; Li, J.; Hu, M.; Sun, H.; Chen, K. Y.-T.; Liu, K.; Yao, S.Q. Inhibitor Fingerprinting of Matrix Metalloproteases Using a Combinatorial Peptide Hydroxamate Library. J. Am. Chem. Soc., 2007, 129, 7848-7858.\r
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Sun, H.; Panicker, R.C.; Yao, S. Q. Activity-based Fingerprinting of Proteases Using FRET Peptides. Biopolymers (Pept. Sci.), 2007, 88, 141-149.\r
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Sun, H.; Chattopadhaya, S.; Wang, J.; Yao, S.Q. Recent development in microarray-based enzyme assays: from functional annotation to substrate/inhibitor fingerprinting. Anal. Bioanal. Chem. 2006, 386, 416-426.\r
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Wang, J.; Uttamchandani, M.; Sun, H.; Yao, S.Q. Application of Microarrays with special tagged libraries. QSAR Comb. Sci. 2006, 11, 1009-1019. \r
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Girish, A.; Sun, H.; Yeo, D.S.Y.; Chen, G.Y.J.; Chua, T.-K.; Yao, S.Q. Site-specific immobilization of proteins in a microarray using intein-mediated protein splicing. Bioorg. Med. Chem. Lett. 2005, 15, 2447-2451.