个人简历

1993年毕业于加拿大明尼多巴大学免疫学系，获博士学位，1985年1988年美国德可萨思州圣安东尼奥西南生物医学研究所病毒免疫学系访问学者，博士后。1993年至2010年曾任加拿大国家食品检验检疫总局国家外来病中心免疫诊断实验室研究员、高级研究员和主任、美国衣阿华州立大学兽医学院兽医诊断和动物生产医学系副教授兽医诊断实验室血清诊断实验室主任、山东省“泰山学者海外专家”等职。

研究领域

1：猪繁殖与呼吸综合征。猪繁殖与呼吸综合征病毒生物学、病毒与宿主互作、免疫调控、诊断试剂疫苗及生物制剂研发。
2：戊型肝炎。禽和猪戊型肝炎病毒生物学、病毒与宿主互作、致病机制、病毒跨种系传播机制、诊断试剂疫苗及生物制剂研发

近期论文

Jiming Gao, Shuqi Xiao, Yihong Xiao, Xiangpeng Wang, Chong Zhang, Qin Zhao, Baichen Huang, Hongliang Liu, Chengbao Wang, Ningning Liu, Junhua Lv, Taofeng Du, Yani Sun, Yang Mu, Gang Wang, Shahid Faraz Syed, Gaiping Zhang, Julian A. Hiscox, Ian Goodfellow and En-Min Zhou*. MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection. Sci Reports. 2016 Apr 26;6:25120. doi: 10.1038/srep25120.
Yongkun Dua, Taofeng Du, Yunpeng Shi, Angke Zhang, Chong Zhang, Yuwen Diao, Guangyi Jin*, En-Min Zhou*. Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages. Antiviral Res. doi:10.1016/j.antiviral.2016.04.005.
Liu H, Liang C, Duan H, Zhang X, Wang X, Xiao S, Zhou EM*. Intracellularly expressed nanobodies against non-structural protein 4 of porcine reproductive and respiratory syndrome virus inhibit virus replication. Biological Lett. DOI 10.1007/s10529-016-2086-3
Yiyang Chen, Qin Zhao, Baoyuan Liu, Lizhen Wang, Yani Sun, Huixia Li, Xinjie Wang, Shahid Faraz Syed, Gaiping Zhang, En-Min Zhou*. A novel blocking ELISA for detection of antibodies against hepatitis E virus in domestic pigs. Plos One. 2016 Mar 29;11(3):e0152639.
Qiongyi Li, Xiangpeng Wang, Chengbao Wang, Ying Yu, Gang Wang, Jiming Gao, Hongliang Liu, Huali Xie, Baicheng Huang, Zhijun Li, Ning Kong, Taofeng Du, Yang Mu, Shuqi Xiao, Qin Zhao, Yani Sun, Xingang Xu, Gaiping Zhang, Walter H. Hsu and En-Min Zhou*. Intracellular expression of an anti-idiotypic antibody single-chain variable fragment inhibits porcine reproductive and respiratory syndrome virus infection in Marc-145 cells. Antiviral Therapy. 2016;21(2):161-70.doi: 10.3851/IMP2980, 20150727. IF：3.02被引次数：0
Hongliang Liu, Yan Wang, Hong Duan, Angke Zhang, Chao Liang, Jiming Gao, Chong Zhang, Baicheng Huang, Qiongyi Li, Na Li, Shuqi Xiao*, En-Min Zhou*. An intracellularly expressed Nsp9-specific nanobody in MARC-145 cells inhibits porcine reproductive and respiratory syndrome virus replication. Vet Microbiol. 2015, 181:252-260.
Chong Zhang, Fengxing Pu, Angke Zhang, Lele Xu, Na Li, Yunhuan Yan, Jiming Gao, Hongliang Liu, Gaiping Zhang, Ian G. Goodfellow, En-Min Zhou*, Shuqi Xiao*. Heme Oxygenase-1 Suppresses Bovine Viral Diarrhoea Virus Replication in vitro. Sci Reports. 2015 Oct 29;5:15575. doi: 10.1038/srep15575.
Zhijun Li, Gang Wang, Yan Wang, Chong Zhang, Xinglong Wang, Baicheng Huang, Qiongyi Li, Liangliang Li, Biyun Xue, Peiyang Ding, Shahid Faraz Syed, Chengbao Wang*, Xuehui Cai*, En-Min Zhou*. Rescue and evaluation of a recombinant PRRSV expressing porcine Interleukin-4. Virol J. 2015, 12:185-194.
Qin Zhao, Shahid Faraz Syed, En-Min Zhou*. Antigenic Properties of Avian Hepatitis E Virus Capsid Protein. Vet Microbiol. 2015, 180:10-14.
Zhijun Li, Gang Wang, Yan Wang, Chong Zhang, Baicheng Huang, Qiongyi Li, Liangliang Li, Biyun Xue, Peiyang Ding, Xuehui Cai, Chengbao Wang*, En-Min Zhou*. Immune responses of pigs immunized with a recombinant porcine reproductive and respiratory syndrome virus expressing porcine GM-CSF. Vet Immunol Immunopathol. 2015, 168:40-48.
Qin Zhao, Sha Xie, Yani Sun, Yiyang Chen, Jiming Gao, Huiya Li, Xinjie Wang, Shahid Faraz Syed, Baoyuan Liu, Lizhen Wang, Gaiping Zhang and En-Min Zhou*. Development and evaluation of a SYBR Green real-time RT-PCR assay for detection of avian Hepatitis E virus. BMC Vet Res. 2015, 11:195-201.
Yang Mu, Liangliang Li, Beibei Zhang, Baicheng Huang, Jiming Gao, Xiangpeng Wang, Chengbao Wang, Shuqi Xiao, Qin Zhao, Yani Sun, Gaiping Zhang, Julian A. Hiscox, En-Min Zhou*. Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells. Virol. 2015, 484:136-145.
Gang Wang†, Ying Yu†, Yabin Tu, Jie Tong, Yonggang Liu, Chong Zhang, Yafei Chang, Shujie Wang, Chenggang Jiang, En-Min Zhou*, Xuehui Cai*. Highly pathogenic porcine reproductive and respiratory syndrome virus infection induced apoptosis and autophagy in thymi of infected piglets. PLoS ONE 10(6): e0128292. doi:10.1371/journal.pone.0128292.
Xinjie Wang, Qin Zhao, Lu Dang, Yani Sun, Jiming Gao, Baoyuan Liu, Shahid Faraz Syed, Hu Tao, Gaiping Zhang, Jianxun Luo, and En-Min Zhou*. Characterization of two novel linear B-cell epitopes in the capsid protein of avian hepatitis E virus (HEV) that are common to avian, swine, and human HEVs. J Virol. 2015, 89(10):5491-5501.
Shuqi Xiao, Xue Wang, Huaibao Ni, Na Li, Angke Zhang, Hongliang Liu, Fengxing Pu, Lele Xu, Jiming Gao, Qin Zhao, Yang Mu, Chengbao Wang, Yani Sun, Taofeng Du, Xingang Xu, Gaiping Zhang, Julian A. Hiscox, Ian G. Goodfellow, En-Min Zhou*. MiR-24-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication through Suppression of Heme Oxygenase-1 Expression. J Virol. 2015, 89(8):4494-4503
Ying Yu, Gang Wang, Qiongyi Li, Yongkun Du, Taofeng Du, Yang Mu, Shuqi Xiao, Qin Zhao, Chengbao Wang,Yani Sun, Xingang Xu, Gaiping Zhang, Walter H. Hsu, Xuehui Cai* and En-Min Zhou*. Single-chain anti-idiotypic antibody retains it specificity to porcine reproductive and respiratory syndrome virus GP5. Immunol Letters. 2014, 163(1):8-13.
Qin Zhao, Yani Sun, Gaiping Zhang, Frederik Widén, En-Min Zhou*. Antigenic domains of avian HEV: bases for serological diagnosis of HEV in avian, swine and human. British J Virol. 2014,1(3): 103-105.
Lizhen Wang, Yani Sun, Taofeng Du, Chengbao Wang, Shuqi Xiao, Yang Mu, Gaiping Zhang, Lihong Liu, Frederik Widén, Walter H. Hsu, Qin Zhao* and En-Min Zhou*. Identification of an antigenic domain in the N-terminal region of avian hepatitis E virus (HEV) capsid protein that is not common to swine and human HEVs. J Gen Virol. 2014, 95:2710-2715.
Jiming Gao, Pengchao Ji, Maodong Zhang, Xiangpeng Wang, Chengbao Wang, Shuqi Xiao, Yang Mu, Qin Zhao, Taofeng Du, Yani Sun, Julian A. Hiscox, Gaiping Zhang, En-Min Zhou*. GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity. Vet Microbiol. 2014, 174(3–4): 409-418.
Xiao YH, Wang TT, Zhao Q, Wang CB, Lv JH, Nie L, Gao JM, Ma XC, Hsu WH, Zhou EM*. Development of indirect ELISAs for differential serodiagnosis of classical and highly pathogenic porcine reproductive and respiratory syndrome virus. Transbound Emerg Dis. 2014, 61:341–349.
Baoyuan Liu, Qin Zhao, Yani Sun, Xinjie Wang, Jinan Zhao, Taofeng Du, Chengbao Wang, Shuqi Xiao, Yang Mu, Gaiping Zhang Jianxun Luo, Walter H. Hsu, En-Min Zhou*. Development of a blocking ELISA for detection of antibodies against avian Hepatitis E virus. J Virological Methods. 2014, 204:1-5.
Shuqi Xiao, Angke Zhang, Chong Zhang, Huaibo Ni, Jiming Gao, Chengbao Wang, Qin Zhao, Xiangpeng Wang, Xue Wang, Chao Ma, Hongliang Liu, Na Li, Yang Mu, Yani Sun, Gaiping Zhang, Julian A. Hiscox, En-Min Zhou*. Heme oxygenase-1 acts as an anti-viral factor for porcine reproductive and respiratory syndrome virus replication and over-expression inhibits virus biology. Antiviral Res. 2014, 110:60–69.
Xin-jie Wang, Qin Zhao, Feng-lin Jiang, Bao-yuan Liu, Ji-nan Zhao, Lu Dang, Ya-ni Sun, Yang Mu, Shu-qi Xiao, Cheng-bao Wang, Walter H. Hsu, Lihong Liu, Frederik Widén, En-Min Zhou*. Genetic characterization and serological prevalence of swine hepatitis E virus in Shandong province, China. Vet Microbiol. 2014, 172:415–424.
Ying Yu, Xuehui Cai, Gang Wang, NingKong, Yonggang Liu, Yihong Xiao, Chong Zhang, Yang Mu, Shuqi Xiao, Qin Zhao, Chengbao Wang, Gaiping Zhang, Julian A. Hiscox, En-Min Zhou*. Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge. BMC Vet Res. 2014, 10:39-48.