个人简历

高锦明，男，教授（二级），博士生导师，陕西省教学名师，享受国务院政府特殊津贴。 1986年7月本科毕业于陕西师范大学化学专业，1998年7月硕士毕业于西北农林科技大学植物资源化学专业，2001年8月获中国科学院昆明植物研究所植物化学专业博士学位。2005年至2006年及2007年至2008年在加拿大科学院生物技术研究所做访问学者和博士后。 2001年获得中国科学院院长奖学金优秀奖；先后入选教育部“优秀青年教师资助计划”、“新世纪优秀人才支持计划”。2005年获陕西省“优秀博士后”，2009年获陕西省优秀留学回国人员称号，以及2014年陕西省化学优秀工作者奖。 现任西北农林科技大学化学与药学院院长，西北农林科技大学第八、九、十、十一届学位评定委员会第十二分委会主席，西北农林科技大学第三、四届学术委员会委员。兼任中国植物学会植物化学及资源学专业委员会委员、中国菌物学会菌物化学专业委员会副主任委员、陕西省天然产物化学生物学重点实验室主任、陕西省资源化学与可持续利用工程研究中心主任、国家自然科学基金会评（二审）专家、陕西省化学会常务理事、陕西省药学会常务理事、陕西省陕南中药产业发展专家顾问。

研究领域

1、中药药效物质基础研究、天然活性成分结构改造与功能研究 2、基于靶蛋白结构的天然产物结构修饰与构效关系 3、新型小分子神经生长因子NGF类化合物发现与药物开发 4、天然产物的生物转化、生物合成与调控

近期论文

Yu-Bin Bai, Zaigang Luo, Yuguang Wang, Jin-Ming Gao*, Liming Zhang*. Au-Catalyzed Intermolecular [2+2] Cycloadditions between Chloroalkynes and Unactivated Alkenes. Journal of the American Chemical Society , 2018, 140: 5860–5865. IF = 14.357 Dan Tang#, Ling-Li Liu#, Qiu-Rui He, Wen Yan, Ding Li, Jin-Ming Gao*. Ansamycins with potential anti-proliferative and anti-neuroinflammatory activity from the moss soil-derived Streptomyces cacaoi subsp. asoensis H2S5. Journal of Natural Products , 2018,DOI:10.1021/acs.jnatprod.8b00203 Chen-Yu Cao, Cheng-Chen Zhang, Xin-Wei Shi, Ding Li, Wei Cao, Xia Yin, Jin-Ming Gao*, Sarcodonin G derivatives exhibit distinctive effects on neurite outgrowth by modulating NGF signaling in PC12 Cells, ACS Chemical Neuroscience , 2018, 9: 1607–1615. Jing Wei#, Yuanyuan Cheng#, Wan-Hui Guo, Da-Cheng Wang, Qiang Zhang, Ding Li, Jianhui Rong*, Jin-Ming Gao*. Molecular diversity and potential anti-neuroinflammatory activities of cyathane diterpenoids from the Basidiomycete Cyathus africanus. Scientific Reports , 2017, 7: 8883. Qiang Zhang#, Hao-Yu Tang#, Min Chen, Jie Yu, Hui Li, Jin-Ming Gao*. Natural products driven diversity via skeletal remodeling of caryophyllene β-lactam. Organic & Biomolecular Chemistry , 2017, 15(20): 4456-4463. Xin Yu, Jiadong Hu, Zhigao Shen, Hui Zhang, Jin-Ming Gao, Weiqing Xie*. Stereospecific construction of contiguous quaternary all-carbon centers by oxidative ring contraction. Angew. Chem. Int. Ed. 2017, 56(1): 350–353. Shuai Dong, Kiran Indukuri, Derrick L. J. Clive*, Jin-Ming Gao*. Models of the BC ring systems of MPC1001 and MPC1001F. Chemical Communications. 2016, 52, 8271-8274. Bo Luo, Jin-Ming Gao*, Mark Lautens*. Palladium-catalyzed norbornene-mediated tandem amination/cyanation reaction: a new method for the convergent synthesis of ortho -aminated benzonitriles. Organic Letters , 2016, 18, 4166−4169. Bai, Rui; Zhang, Cheng-Chen; Yin, Xia; Wei, Jing; Gao, Jin-Ming*. Cyathane diterpenoids with neurotrophic activity from cultures of the fungus Cyathus striatus . Journal of Natural Products , 2015, 78(4): 783–788. Bai, Meng-Meng#; Shi, Wei#; Tian, Jun-Mian; Lei Ming; Kim, Young Ho; Kim, Jang Hoon*; Sun, Ya Nan; Gao, Jin-Ming*. Soluble epoxide hydrolase inhibitory and anti-inflammatory components from the leaves of Eucommia ulmoides Oliver (Duzhong). Journal of Agricultural and Food Chemistry, 2015 , 63 (8): 2198–2205. Zhang, Qiang; Xiao, Jian; Sun, Qing-Qing; Qin, Jian-Chun; Pescitelli, Gennaro; Gao, Jin-Ming*. Characterization of cytochalasins from the endophytic Xylaria sp. and their biological functions. Journal of Agricultural and Food Chemistry, 2014, 62(45): 10962–10969. Dong-Mei Wang#, Cheng-Chen Zhang#, Qiang Zhang, Nusrat Shafiq, Gennaro Pescitelli, Deng-Wu Li, Jin-Ming Gao*. Wightianines A–E, dihydro-β-agarofuran sesquiterpenes from Parnassia wightiana , and their antifungal and insecticidal activities. Journal of Agricultural and Food Chemistry, 2014, 62(28): 6669–6676. Shuai Dong, Jiang-Jiang Tang*, Cheng-Chen Zhang, Jun-Mian Tian, Jun-Tao Guo, Qiang Zhang, He Li, Jin-Ming Gao*. Semisynthesis and in vitr o cytotoxic evaluation of new analogues of 1- O -acetylbritannilactone, a sesquiterpene from Inula britannica . European Journal of Medcinal Chemistry 2014, 80 , 71–82. Qiang Zhang, Shi-Qiong Wang, Hao-Yu Tang, Xiao-Jun Li, Lu Zhang, Jian Xiao, Yu-Qi Gao, An-Ling Zhang, Jin-Ming Gao*. Potential allelopathic indole diketopiperazines produced by the plant endophytic Aspergillus fumigatus using the one strain−many compounds method. Journal of Agricultural and Food Chemistry, 2013, 61(47):11447–11452. (Cover image) Jin-Ming Gao*, Sheng-Xiang Yang, Jian-Chun Qin. Azaphilonoids: Chemistry and Biology, Chemical Reviews , 2013, 113(7): 4755–4811. (IF = 45.661) Yu-Bin Bai, An-Ling Zhang, Jiang-Jiang Tang, Jin-Ming Gao*. Synthesis and antifungal activity of 2-­chloromethyl-1H-­benzimidazole derivatives against phytopathogenic Fungi in vitro . Journal of Agricultural and Food Chemistry, 2013, 61 (11): 2789–2795. Han-Wei Liu, Xiu-Zhu Yu, Daniele Padula, Gennaro Pescitelli, Zhi-Wei Lin, Fei Wang, Kai Ding, Ming Lei, Jin-Ming Gao*. Lignans from Schisandra sphenathera Rehd. et Wils. and synthetic schisantherin A analogues: absolute configuration, and their estrogenic and anti-proliferative activity. European Journal of Medcinal Chemistry , 2013, 59(1): 265-273. Xiao-Jun Li, Qiang Zhang, An-Ling Zhang, Jin-Ming Gao*. Metabolites from Aspergillus fumigatus , an endophytic fungus associated with Melia azedarach , and their antifungal, antifeedant, and toxic activities. Journal of Agricultural and Food Chemistry, 2012, 60 (13): 3424–3431.（ESI高被引论文） Sheng-Xiang Yang, Hong-Peng Wang, Jin-Ming Gao*, Qiang Zhang, Hartmut Laatsch*, and Yi Kuang. Fusaroside, a uinque glycolipid isolated from Fusarium sp., an endophytic fungus in Melia azedarach . Organic & Biomolecular Chemistry , 2012, 10(4): 819-824. Jin-Ming Gao*, Wen-Jun Wu, Ji-Wen Zhang, Yasuo Konishi, The dihydro- b -agarofuran sesquiterpenoids, Natural Product Reports , 2007, 24(5)： 1153–1189. (IF = 11.715)