个人简历

入选陕西省‘百人计划’、教育部‘新世纪优秀人才支持计划’。 中国科学院上海药物研究所有机化学博士、美国约翰·霍普金斯大学和哈佛大学医学院博士后（Instructor）。中国生物化学与分子生物学会复合糖专业委员会委员、陕西省药学会理事、陕西省药学会药物化学专委会委员。以第一或通讯作者在Cell host & microbe 、PNAS、Glycobiology（4）、Carbohydrate Polymers（10）等上发表SCI论文60余篇，获批专利5项。

研究领域

""1）天然多（寡）糖的功能机制：抗肿瘤、抗肥胖及肠道菌群调控等 2）基于多（寡）糖的药物构建及应用"""多（寡）糖生物学：\r
1）天然多（寡）糖的功能机制：抗肿瘤、抗肥胖及肠道菌群调控等\r
2）基于多（寡）糖的药物构建及应用"

近期论文

Synergistic clearance of intracellular pathogens by hyaluronan-streptomycin micelles encapsulated with rapamycin. Qiu Y, Lu C, Chen P, Sun F, Wang D, Wang Z, Hou C, Mu H, Duan J. Carbohydr Polym . 2019 Apr 15;210:364-371. Protein-Bound β-glucan from Coriolus Versicolor has Potential for Use Against Obesity. Li X, Chen P, Zhang P, Chang Y, Cui M, Duan J. Mol Nutr Food Res . 2019 Jan 22:e1801231. doi: 10.1002/mnfr.201801231. A photo-controlled hyaluronan-based drug delivery nanosystem for cancer therapy. Sun F, Zhang P, Liu Y, Lu C, Qiu Y, Mu H, Duan J.Carbohydr Polym. 2019 Feb 15;206:309-318. Light controllable chitosan micelles with ROS generation and essential oil release for the treatment of bacterial biofilm.Wang Z, Bai H, Lu C, Hou C, Qiu Y, Zhang P, Duan J, Mu H. Carbohydr Polym . 2019 Feb 1;205:533-539. Antidepressant and immunosuppressive activities of two polysaccharides from Poria cocos (Schw.) Wolf. Zhang W, Chen L, Li P, Zhao J, Duan J. Int J Biol Macromol . 2018 Dec;120(Pt B):1696-1704. Sulfated modification and biological activities of polysaccharides derived from Zizyphus jujuba cv. Jinchangzao. Cai Y, Chen P, Wu C, Duan J, Bai H. Int J Biol Macromol . 2018 Dec;120(Pt A):1149-1155. A hyaluronan-based nanosystem enables combined anti-inflammation of mTOR gene silencing and pharmacotherapy. Hou C, Bai H, Wang Z, Qiu Y, Kong LL, Sun F, Wang D, Yin H, Zhang X, Mu H, Duan J. Carbohydr Polym . 2018 Sep 1;195:339-348. Inulin based glutathione-responsive delivery system for colon cancer treatment. Wang D, Sun F, Lu C, Chen P, Wang Z, Qiu Y, Mu H, Miao Z, Duan J. Int J Biol Macromol . 2018 May;111:1264-1272. A novel photocleavable heparin derivative with light controllable anticoagulant activity. Sun F, Liu Y, Wang D, Wang Z, Mu H, Wang F, Ding K, Duan J. Carbohydr Polym . 2018 Mar 15;184:191-198. Synthesis of hyaluronan-amikacin conjugate and its bactericidal activity against intracellular bacteria in vitro and in vivo. Wang Z, Qiu Y, Hou C, Wang D, Sun F, Li X, Wang F, Yi H, Mu H, Duan J. Carbohydr Polym . 2018 Feb 1;181:132-140. Hyaluronic acid conjugation facilitates clearance of intracellular bacterial infections by streptomycin with neglectable nephrotoxicity. Qiu Y, Hou Y, Sun F, Chen P, Wang D, Mu H, Zhang X, Ding K, Duan J. Glycobiology . 2017 Sep 1;27(9):861-867. Novel moisture-preserving derivatives of hyaluronan resistant to hyaluronidase and protective to UV light. Sun F, Niu H, Wang D, Wu Y, Mu H, Ma L, Duan J. Carbohydr Polym . 2017 Feb 10;157:1198-1204. Synthesis, characterization and anticancer activity of tanshinone I grafted low molecular chitosan. Wang D, DanXu, Sun Y, Wu Y, Ma L, Duan J. Glycoconj J . 2017 Feb;34(1):3-12. A tanshinone I derivative enhances the activities of antibiotics against Staphylococcus aureus in vitro and in vivo. Wang D, Lu C, Sun F, Cui M, Mu H, Duan J, Geng H. Res Microbiol . 2017 Jan;168(1):46-54. Chitosan conjugation enables intracellular bacteria susceptible to aminoglycoside antibiotic. Mu H, Niu H, Wang D, Sun F, Sun Y, Duan J. Glycobiology . 2016 Nov;26(11):1190-1197. Preparation and sulfation of an α-glucan from Actinidia chinensis roots and their potential activities. Niu H, Song D, Sun Y, Zhang W, Mu H, Duan J. Int J Biol Macromol . 2016 Nov;92:981-987. Autophagy promotes DNA-protein crosslink clearance. Mu H, Liu Q, Niu H, Wang D, Tang J, Duan J. Mutat Res Genet Toxicol Environ Mutagen . 2016 Feb;797:21-5. Investigation of three lignin complexes with antioxidant and immunological capacities from Inonotus obliquus. Niu H, Song D, Mu H, Zhang W, Sun F, Duan J. Int J Biol Macromol . 2016 May;86:587-93. Novel pH-sensitive polysialic acid based polymeric micelles for triggered intracellular release of hydrophobic drug. Zhang W, Dong D, Li P, Wang D, Mu H, Niu H, Duan J. Carbohydr Polym . 2016 Mar 30;139:75-81. Structural characterization and biological activities of two α-glucans from radix paeoniae alba. Zhang W, Li P, Song D, Niu H, Shi S, Wang S, Duan J. Glycoconj J . 2016 Apr;33(2):147-57. Potent Antibacterial Nanoparticles against Biofilm and Intracellular Bacteria. Mu H, Tang J, Liu Q, Sun C, Wang T, Duan J. Sci Rep. 2016 Jan 5;6:18877. doi: 10.1038/srep18877. Characterization of polysaccharides with antioxidant and immunological activities from Rhizoma Acori Tatarinowii. Zhang W, Song D, Xu D, Wang T, Chen L, Duan J. Carbohydr Polym . 2015 Nov 20;133:154-62. Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives. Wang D, Zhang W, Wang T, Li N, Mu H, Zhang J, Duan J. Int J Mol Sci . 2015 Jul 31;16(8):17668-81. Mechanistic insights into cellular immunity of chondroitin sulfate A and its zwitterionic N-deacetylated derivatives. Zhang W, Sun F, Niu H, Wang Q, Duan J. Carbohydr Polym . 2015 Jun 5;123:331-8. Characterization of two water-soluble lignin metabolites with antiproliferative activities from Inonotus obliquus. Wang Q, Mu H, Zhang L, Dong D, Zhang W, Duan J. Int J Biol Macromol . 2015 Mar;74:507-14. Chitosan improves anti-biofilm efficacy of gentamicin through facilitating antibiotic penetration. Mu H, Guo F, Niu H, Liu Q, Wang S, Duan J. Int J Mol Sci . 2014 Dec 3;15(12):22296-308. Purification, antioxidant and immunological activities of polysaccharides from Actinidia Chinensis roots. Zhang L, Zhang W, Wang Q, Wang D, Dong D, Mu H, Ye XS, Duan J. Int J Biol Macromol . 2015 Jan;72:975-83. Alteration in immune responses toward N-deacetylation of hyaluronic acid. Zhang W, Mu H, Dong D, Wang D, Zhang A, Duan J. Glycobiology . 2014 Dec;24(12):1334-42. Extraction optimization, characterization and immunity activity of polysaccharides from Fructus Jujubae. Cui G, Zhang W, Wang Q, Zhang A, Mu H, Bai H, Duan J. Carbohydr Polym . 2014 Oct 13;111:245-55.