个人简历

常明欣，教授，博士生导师。本科和博士分别毕业于中国科学技术大学、美国新泽西州立大学。

研究领域

"""""主要研究领域为手性胺类化合物的不对称催化合成:利用不对称还原胺化、不对称氢化等绿色反应高效合成手性胺类化合物，特别是相关药物中间体；手性膦配体的设计与合成。"

近期论文

Gao, Z.; Liu, J,; Huang, H.; Geng, H.;* Chang, M.* “An Iridium Catalytic System Compatible with Inorganic and Organic Nitrogen Sources for Dual Asymmetric Reductive Amination Reactions”, Angew. Chem. Int. Ed. 2021 , 60, 27307−27311. (doi.org/10.1002/anie.202112671)\r
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Yuan, S.; Gao, G.; Wang, L.; Liu, C.; Wan, L.; Huang, H,;* Geng, H.;* Chang, M.* “The combination of asymmetric hydrogenation of olefins and direct reductive amination”, Nat. Commun. , 2020, 11 , 621. (doi.org/10.1038/s41467-020-14475-x)\r
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Wu, Z.; Du, S.; Gao, G.; Yang, W.; Huang, H.; Chang, M.* “Secondary amines as coupling partners in direct catalytic asymmetric reductive amination”, Chem. Sci. 2019, 10 , 4509−4514. (doi.org/10.1039/C9SC00323A)\r
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Zhou, H.; Liu, Y.; Yang, S.; Zhou, L.; Chang, M.*, “One-pot N-Boc Deprotection and Catalytic Intramolecular Asymmetric Reductive Amination for the Synthesis of Tetrahydroisoquinolines”, Angew. Chem. Int. Ed. 2017 , 56, 2725−2729. (doi.org/10.1002/anie.201611181; Highlighted by Synfacts , 2017, 13 , 0585；Science Foundation in China)\r
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Huang, H.; Zhao, Y.; Yang, Y.; Zhou, L.; Chang, M.* “Direct Catalytic Asymmetric Reductive Amination of Aliphatic Ketones Utilizing Diphenylmethanamine as Coupling Partner”, Org. Lett . 2017, 19 , 1942−1945. (doi.org/10.1021/acs.orglett.7b00212; Highlighted by Synfacts , 2017, 13, 0614)\r
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Huang, H.; Liu, X.; Zhou, L.;* Chang, M.;* Zhang, X. “Direct Asymmetric Reductive Amination for the Synthesis of Chiral b-Arylamines”, Angew. Chem. Int. Ed. 2016 , 55, 5309. (doi.org/10.1002/anie.201601025; Highlighted by Synfacts , 2016, 12 , 0609, Organic Chemistry , X-MOL and Advanced Science News)\r
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Chang, M.; Huang, Y.; Liu, S.; Chen, Y.;* Krska, S. W.; Davies, I. W.; Zhang, X.* “Asymmetric Hydrogenation of Pyridinium Salts with an Iridium Phosphole Catalyst ”, Angew. Chem. Int. Ed . 2014, 53, 12761. (doi.org/10.1002/anie.201406762; Highlighted by Synfacts, 2014, 10, 1291).\r
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Chang, M.; Li, W.; Zhang, X.* “A Highly Efficient and Enantioselective Access to Tetrahydroisoquinoline Alkaloids via Asymmetric Hydrogenation with an Iridium Catalyst”, Angew. Chem. Int. Ed . 2011, 50, 10679. (doi.org/10.1002/anie.201104476)\r