个人简历

郭媛，西北大学化学与材料科学学院教授、博士生导师，主讲化学学科本科《有机化学》、研究生《化学生物学》等课程。兼任法国国立奥尔良大学特邀教授、陕西高校新型智库化工助剂与新材料发展研究中心学术委员会委员、《精细化工》杂志编委、《Chinese Chemical Letters》杂志青年编委。近年来，聚焦“分子探针与生物分子示踪”方向开展研究工作，先后承担国家自然科学基金4项（面上项目3项、青年基金1项）、国家自然科学基金重点项目（1/2）、陕西省“杰出青年”科学基金（2020年）、陕西省留学归国人员科技活动择优资助项目、生物反应器工程国家重点实验室开放基金、西北大学“优秀青年学术骨干支持计划”项目等。在国内外学术刊物上发表研究论文50余篇，授权发明专利10项。作为主要完成人，分别于2005年、2010年获得陕西省科学技术壹等奖、叁等奖。2009年获西北大学第八届青年教师讲课比赛一等奖、2015年获西北大学化学与材料科学学院讲课比赛特等奖、2016年获西安市青年科技人才奖。

研究领域

""分子探针与生物分子示踪""""

近期论文

Li Xiaokang; Qiu Wenjing; Li Jinwen; Chen Xi; HuYulu; Gao Ying; Shi Donglei; Li Xinming; Lin Huiling; Hu Zela; Dong Guoqiang; Sheng Chunquan; Jiang Bei; Xia Conglong; Kim Chu-Young; Guo Yuan*, Li Jian*; First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase, Chemical Science, 2020, 11, 7292-7301. (Front cover)\r
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Shi Donglei; Hu Linghao; Li Xinming; Liu Wenwen; Gao Ying; Li Xiaokang; Jiang Bei; Xia Conglong; Guo Yuan*; Li Jian*; Lysosomal polarity increases with aging as revealed by a lysosome-targetable near-infrared fluorescent probe, Sensors and Actuators B: Chemical, 2020, 319: 128302.\r
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Teng Hao; Tian Jingye; Sun Donghuan; Xiu Mengxue; Zhang Yanhui; Qiang Xingyu; Tang Haoyang*; Guo Yuan*; A mitochondria-specific fluorescent probe based on triazolopyridine formation for visualizing endogenous hypochlorous acid in living cells and zebrafish, Sensors and Actuators B: Chemical, 2020, 319: 128288.\r
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Zhang Yanhui; Teng Hao; Gao Ying; Afzal Muhammad Wasim; Tian Jingye; Chen Xi; Tang Haoyang; James Tony D.; Guo Yuan*; A general strategy for selective detection of hypochlorous acid based on triazolopyridine formation, Chinese Chemical Letters, 2020, 31: 2917-2920. (Front cover)\r
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Hu Linghao; Shi Donglei; Li Xinming; Zhu Jin; Mao Fei; Li Xiaokang; Xia Conglong; Jiang Bei; Guo Yuan*; Li Jian*; Curcumin-based polarity fluorescent probes: Design strategy and biological applications, Dyes and Pigments, 2020, 177: 108320.\r
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Shi Donglei; Chen Shuqiang; Dong Biao; Zhang Yanhui; Sheng Chunquan; James Tony D.; Guo Yuan*; Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe, Chemical Science, 2019, 10: 3715-3722. (Back cover)\r
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Li Jin; Yin Xinchi; Li Bin; Li Xiaokang; Pan Yuanjiang; Li Jian; Guo Yuan*; Spiropyran in situ switching: A real-time fluorescence strategy for tracking DNA G-quadruplexes in live cells, Analytical Chemistry, 2019, 91: 5354-5361. 
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Liu Qimeng; Li Anyang; Li Xiaokang; Li Bin; Zhang Yanhui; Li Jian; Guo Yuan*; Selective visualization of live-cell mitochondrial thiophenols and their induced oxidative stress process by a rationally designed rhodol-based fluorescent probe, Sensors and Actuators B: Chemical, 2019, 283: 820-830.\r
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Li Jin; Gao Ying; Guo Haoran; Li Xiaokang; Tang Haoyang; Li Jian; Guo Yuan*; A novel colorimetric and ratiometric fluorescent probe for selective detection of bisulfite in real samples and living cells, Dyes and Pigments, 2019, 163: 285-290.\r
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Li Jin; Li Xiaokang; Jia Jianbo; Chen Xi; Lv Yinjuan; Guo Yuan*; Li Jian*; A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH, Dyes and Pigments, 2019, 166: 433-442.\r
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Liu Qimeng; Wang Huan; Guo Haoran; Guo Yuan*; A highly selective coumarin-based fluorescent probe for detecting Fe3+ in pure water systems and living cells, Chinese Journal of Inorganic Chemistry, 2019, 35: 923-929.\r
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Wang Huan; Shi Donglei; Li Jin; Tang Haoyang; Li Jian; Guo Yuan*; A facile fluorescent probe with a large Stokes shift for sequentially detecting copper and sulfide in 100% aqueous solution and imaging them in living cells, Sensors and Actuators B: Chemical, 2018, 256: 600-608.\r
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Tang Haoyang; Gao Ying; Li Bin; Li Changwei; Guo Yuan*; Reaction-based colorimetric and ratiometric fluorescent probe for highly selective detection of silver ions, Sensors and Actuators B: Chemical, 2018, 270: 562-569.\r
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Zhang Yanhui; Ma Lin; Tang Chunchao; Pan Shengnan; Shi Donglei; Wang Shaojing; Li Minyong*; Guo Yuan*; A highly sensitive and rapidly responding fluorescent probe based on a rhodol fluorophore for imaging endogenous hypochlorite in living mice, Journal of Materials Chemistry B, 2018, 6: 725-731. (Front cover)\r
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Wang Shaojing; Li Jin; Gao Ying; Guo Yuan*; Highly selective and sensitive 2-(2’-hydroxyphenyl) benzothiazole-based turn-on fluorescent probes for detecting and imaging bisulfite in living cells, Asian Journal of Organic Chemistry, 2018, 7: 563-569.\r
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