苟兴春
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个人简历
苟兴春,男,1973年3月出生,医学博士,博士后、教授、耶鲁大学访问学者。第四军医大学硕士研究生导师。陕西省中青年科技创新领军人才、国家创新创业优秀导师、西安医学院领军人才。现任西安医学院科技处副处长。生物学学士、神经生物学硕士、细胞生物学博士、麻醉学博士后、耶鲁大学神经外科访问学者。专长于神经再生与脑保护、阿尔茨海默病的机制与防治。2010年被CancerScience授予“青年科学家奖”(YoungScientistAward)。教育、工作经历:1992-1996年,兰州大学生命科学学院;1996-2003年,西安迪赛生物药业,工程师2003年就读第四军医大学神经生物学硕士研究生,在导师鞠躬院士指导下,从事中枢神经再生的研究,2006年7月获硕士学位;2006年9月就读第四军医大学细胞生物学专业,攻读博士学位,导师为陈志南院士,从事自噬与肿瘤的相关研究。2009年-至今,在西安医学院细胞生物学教研室任教与科研;2011年-2013年,第四军医大学麻醉学专业博士后;2013.12-2014.12,耶鲁大学神经外科访问学者。研究领域
主要研究方向:为神经再生与修复、老年痴呆机制及防治。"科研项目:现主持国家自然科学基金面上项目3项(其中已结题2项),省教育厅和卫生厅科研计划各1项,人社厅留学基金1项,陕西省重点项目1项,总科研经费近200万元。是西安医学院第一个国家自然科学基金获得者。国家自然科学基金主持项目(3项)1、2014年国家自然科学基金面上项目,70万。(81471415)\"Aβ-PirB-Tau\"通路调控突触可塑性:阿尔茨海默症发生的分子机制及防治策略探讨。2、2010年国家自然科学基金面上项目,30万。(81071060)PirB重链VHH抗体的筛选及其治疗脑缺血损伤的研究。3、2012年国家自然科学基金面上项目,70万。(81271290)靶向运载Ngn2诱导星形胶质细胞转分化为神经元:促进缺血性脑损伤后神经功能恢复的新策略。"近期论文
1.Yu,X.,X.Gou(共一),P.Wu,L.Han,D.Tian,F.Du,Z.Chen,F.Liu,G.Deng,A.T.Chen,C.Ma,J.Liu,S.M.Hashmi,X.Guo,X.Wang,H.Zhao,X.Liu,X.Zhu,K.Sheth,Q.Chen,L.Fan,andJ.Zhou,ActivatableProteinNanoparticlesforTargetedDeliveryofTherapeuticPeptides.AdvMater,2018.30(7).2.Wang,X.,X.Liu,Y.Ren,Y.Liu,S.Han,J.Zhao,X.Gou(通讯),andY.He,PEDFprotectshumanretinalpigmentepithelialcellsagainstoxidativestressviaupregulationofUCP2expression.MolMedRep,2018.3.Lao,K.,N.Ji,X.Zhang,W.Qiao,Z.Tang,andX.Gou(通讯),DrugDevelopmentforAlzheimer'sDisease:Review.JDrugTarget,2018:p.1-29.4.Guo,X.,G.Deng,J.Liu,P.Zou,F.Du,F.Liu,A.T.Chen,R.Hu,M.Li,S.Zhang,Z.Tang,L.Han,J.Liu,K.N.Sheth,Q.Chen,X.Gou(通讯),andJ.Zhou,Thrombin-Responsive,Brain-TargetingNanoparticlesforImprovedStrokeTherapy.ACSNano,2018.12(8):p.8723-8732.5.Guo,H.,L.Xun,R.Zhang,andX.Gou(通讯),RatioofCD147(high)/CD147(low)inCD4(+)CD25(+)Tcells:Apotentialbiomarkerforearlydiagnosisandpredictionofresponsetotherapyforautoimmunediseases.MedHypotheses,2018.115:p.1-4.6.Gao,X.,Y.Mi,N.Guo,H.Xu,P.Jiang,R.Zhang,L.Xu,andX.Gou(通讯),GliomainSchizophrenia:IstheRiskHigherorLower?FrontCellNeurosci,2018.12:p.289.7.Deng,B.,L.Li,X.Gou(共一),H.Xu,Z.Zhao,Q.Wang,andL.Xu,TAT-PEPEnhancedNeurobehavioralFunctionalRecoverybyFacilitatingAxonalRegenerationandCorticospinalTractProjectionAfterStroke.MolNeurobiol,2018.55(1):p.652-667.8.Zhao,Z.H.,B.Deng,H.Xu,J.F.Zhang,Y.J.Mi,X.Z.Meng,X.C.Gou(通讯),andL.X.Xu,PirBOverexpressionExacerbatesNeuronalApoptosisbyInhibitingTrkBandmTORPhosphorylationAfterOxygenandGlucoseDeprivationInjury.CellMolNeurobiol,2017.37(4):p.707-715.9.Zhao,W.,H.Qian,R.Zhang,X.Gao,andX.Gou(通讯),MicroRNAtargetingmicrotubulecross-linkedprotein(MACF1)wouldsuppresstheinvasionandmetastasisofmalignanttumor.MedHypotheses,2017.104:p.25-29.10.Mi,Y.J.,H.Chen,N.Guo,M.Y.Sun,Z.H.Zhao,X.C.Gao,X.L.Wang,R.S.Zhang,J.B.Zhou,andX.C.Gou(通讯),InhibitionofPirBActivitybyTAT-PEPImprovesMouseMotorAbilityandCognitiveBehavior.FrontAgingNeurosci,2017.9:p.199.11.Gao,X.,Y.Mi,N.Guo,H.Xu,L.Xu,X.Gou(通讯),andW.Jin,Cytokine-InducedKillerCellsAsPharmacologicalToolsforCancerImmunotherapy.FrontImmunol,2017.8:p.774.12.Dang,Y.,T.Liu,X.Mei,X.Meng,X.Gou,B.Deng,H.Xu,andL.Xu,Hyperoxygenatedhydrogen-richsolutionsuppressesshock-andresuscitation-inducedliverinjury.JSurgRes,2017.220:p.363-371.13.Han,L.,Q.Cai,D.Tian,D.K.Kong,X.Gou,Z.Chen,S.M.Strittmatter,Z.Wang,K.N.Sheth,andJ.Zhou,Targeteddrugdeliverytoischemicstrokeviachlorotoxin-anchored,lexiscan-loadednanoparticles.Nanomedicine,2016.12(7):p.1833-1842.14.Gou,X.,X.Tang,D.K.Kong,X.He,X.Gao,N.Guo,Z.Hu,Z.Zhao,andY.Chen,CD147isincreasedinHCCcellsunderstarvationandreducescelldeaththroughupregulatingp-mTORinvitro.Apoptosis,2016.21(1):p.110-9.15.Gao,X.,Y.Mi,N.Guo,Z.Hu,F.Hu,D.Liu,L.Gao,X.Gou(通讯),andW.Jin,Disruptedinschizophrenia1(DISC1)inhibitsglioblastomadevelopmentbyregulatingmitochondriadynamics.Oncotarget,2016.7(52):p.85963-85974.16.Zhao,Y.,B.Deng,Y.Li,L.Zhou,L.Yang,X.Gou,Q.Wang,G.Chen,H.Xu,andL.Xu,ElectroacupuncturePretreatmentAttenuatesCerebralIschemicInjuryviaNotchPathway-MediatedUp-RegulationofHypoxiaInducibleFactor-1alphainRats.CellMolNeurobiol,2015.35(8):p.1093-103.17.Wang,Q.,Y.Sun,Y.Ren,Y.Gao,L.Tian,Y.Liu,Y.Pu,X.Gou,Y.Chen,andY.Lu,UpregulationofEMMPRIN(OX47)inRatDorsalRootGanglionContributestotheDevelopmentofMechanicalAllodyniaafterNerveInjury.NeuralPlast,2015.2015:p.249756.18.Gou,X.C.,D.Kong,andX.Tang,ContradictoryRelationshipsbetweenCancerandNormalCellsandImplicationsforAnti-cancerTherapy.AsianPacJCancerPrev,2015.16(13):p.5143-7.19.Gao,X.,Y.Mi,A.Yan,B.Sha,N.Guo,Z.Hu,N.Zhang,F.Jiang,andX.Gou,ThePHLDB1rs498872(11q23.3)polymorphismandgliomarisk:Ameta-analysis.AsiaPacJClinOncol,2015.11(4):p.e13-21.20.Chen,Y.,X.Gou,D.K.Kong,X.Wang,J.Wang,Z.Chen,C.Huang,andJ.Zhou,EMMPRINregulatestumorgrowthandmetastasisbyrecruitingbonemarrow-derivedcellsthroughparacrinesignalingofSDF-1andVEGF.Oncotarget,2015.6(32):p.32575-85.21.Sha,B.,W.Gao,S.Wang,X.Gou,W.Li,X.Liang,Z.Qu,F.Xu,andT.J.Lu,Oxidativestressincreasedhepatotoxicityinducedbynano-titaniumdioxideinBRL-3AcellsandSprague-Dawleyrats.JApplToxicol,2014.34(4):p.345-56.22.Guo,N.,A.Yan,X.Gao,Y.Chen,X.He,Z.Hu,M.Mi,X.Tang,andX.Gou(通讯),Berberinesensitizesrapamycinmediatedhumanhepatomacelldeathinvitro.MolMedRep,2014.10(6):p.3132-8.23.Guo,F.,W.L.Jin,L.Y.Li,W.Y.Song,H.W.Wang,X.C.Gou,Y.J.Mi,Q.Wang,andL.Xiong,M9,anovelregionofamino-Nogo-A,attenuatescerebralischemicinjurybyinhibitingNADPHoxidase-derivedsuperoxideproductioninmice.CNSNeurosciTher,2013.19(5):p.319-28.24.Gou,X.,Q.Zhang,N.Xu,B.Deng,H.Wang,L.Xu,andQ.Wang,Spatio-temporalexpressionofpairedimmunoglobulin-likereceptor-Bintheadultmousebrainafterfocalcerebralischaemia.BrainInj,2013.27(11):p.1311-5.25.Deng,B.,X.Gou(共一),H.Chen,L.Li,H.Zhong,H.Xu,F.Jiang,Z.Zhao,Q.Wang,andL.Xu,Targeteddeliveryofneurogenin-2proteininthetreatmentforcerebralischemia-reperfusioninjury.Biomaterials,2013.34(34):p.8786-97.26.Wang,Q.,F.Wang,X.Li,Q.Yang,X.Li,N.Xu,Y.Huang,Q.Zhang,X.Gou,S.Chen,andL.Xiong,Electroacupuncturepretreatmentattenuatescerebralischemicinjurythroughalpha7nicotinicacetylcholinereceptor-mediatedinhibitionofhigh-mobilitygroupbox1releaseinrats.JNeuroinflammation,2012.9:p.24.27.Chen,Y.,X.Gou,X.Ke,H.Cui,andZ.Chen,HumantumorcellsinduceangiogenesisthroughpositivefeedbackbetweenCD147andinsulin-likegrowthfactor-I.PLoSOne,2012.7(7):p.e40965.28.Hou,Q.,X.Tang,H.Liu,J.Tang,Y.Yang,X.Jing,Q.Xiao,W.Wang,X.Gou,andZ.Wang,BerberineinducescelldeathinhumanhepatomacellsinvitrobydownregulatingCD147.CancerSci,2011.102(7):p.1287-92.29.Gou,X.,Q.Wang,Q.Yang,L.Xu,andL.Xiong,TAT-NEP1-40asanoveltherapeuticcandidateforaxonalregenerationandfunctionalrecoveryafterstroke.JDrugTarget,2011.19(2):p.86-95.30.Wang,Q.,Y.Peng,S.Chen,X.Gou,B.Hu,J.Du,Y.Lu,andL.Xiong,Pretreatmentwithelectroacupunctureinducesrapidtolerancetofocalcerebralischemiathroughregulationofendocannabinoidsystem.Stroke,2009.40(6):p.2157-64.31.Wang,Q.,X.Gou(共一),W.Jin,L.Xiong,L.Hou,S.Chen,H.Zhang,X.Zhu,andL.Xu,TAT-mediatedproteintransductionofNogoextracellularpeptide1-40anditsbiologicalactivity.CellMolNeurobiol,2009.29(1):p.97-108.32.Wang,Q.,Q.Ding,Y.Zhou,X.Gou,L.Hou,S.Chen,Z.Zhu,andL.Xiong,Ethylpyruvateattenuatesspinalcordischemicinjurywithawidetherapeuticwindowthroughinhibitinghigh-mobilitygroupbox1releaseinrabbits.Anesthesiology,2009.110(6):p.1279-86.33.Gou,X.,Q.Ru,H.Zhang,Y.Chen,L.Li,H.Yang,J.Xing,andZ.Chen,HAb18G/CD147inhibitsstarvation-inducedautophagyinhumanhepatomacellSMMC7721withaninvolvementofBeclin1down-regulation.CancerSci,2009.100(5):p.837-43.34.Chen,Y.,H.Zhang,X.Gou,Y.Horikawa,J.Xing,andZ.Chen,UpregulationofHAb18G/CD147inactivatedhumanumbilicalveinendothelialcellsenhancestheangiogenesis.CancerLett,2009.278(1):p.113-21.35.Wang,Q.,X.Gou(共一),L.Xiong,W.Jin,S.Chen,L.Hou,andL.Xu,Trans-activatoroftranscription-mediateddeliveryofNEP1-40proteinintobrainhasaneuroprotectiveeffectagainstfocalcerebralischemicinjuryviainhibitionofneuronalapoptosis.Anesthesiology,2008.108(6):p.1071-80.中国细胞生物学学会第十届理事、陕西省细胞生物学学会常务理事、中国药理学会麻醉分会委员、陕西省肿瘤标志委员会委员、转化医学电子杂志编委CancerTranslationalMedicine编委会成员 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